Results 211 to 220 of about 935,518 (288)

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, Volume 3, Issue 3, September 2026.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

Zwitterionic Penicillin-Derived Sulfone Inhibitor for Combating β-Lactamase-Mediated Antibiotic Resistance. [PDF]

ChemMedChem
Rodríguez D, Lence E, Vázquez-Ucha JC, Beceiro A, González-Bello C.   +4 more
europepmc   +1 more source

Dose Selection for Ceftibuten Combined with Avibactam Tomilopil, a Potential Oral Alternative to Carbapenems for Patients with Complicated Urinary Tract Infections

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract There are currently no oral treatment options for infections caused by extended spectrum β‑lactamase‐producing Enterobacterales. Avibactam tomilopil, a novel oral prodrug of avibactam, is being developed in combination with the oral cephalosporin, ceftibuten, as a potential treatment for patients with complicated urinary tract infections ...
Siddhee A. Sahasrabudhe, Satoshi Shoji, Abhijeet S. Jakate, Bisrat K. Abraham, Sima S. Toussi, Benjamin J. Maligalig, Amanda S. Darekar, Sakambari Tripathy, Constantino Kantaridis, Josue K. Mfopou, Oxana Selivanova, Arthur Bergman, Negar Niki Alami, Ravi Shankar P. Singh   +13 more
wiley   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, Volume 57, Issue 9, Page 1554-1564, September 2026.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Environmental factors modulate β-lactamase phenotypes: effect of pH and redox potential on β-lactam resistance. [PDF]

Microbiol Spectr
Anbo M, Jensen JD, Ivanova M, Nielsen HN, Svendsen CA, Otani S, Aarestrup FM.   +6 more
europepmc   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

In silico genomic analysis of resistome, virulome, and mobilome of β-lactamase-producing Klebsiella pneumoniae. [PDF]

Sci Rep
Biswas R, Anbarasu A.
europepmc   +1 more source

Development of a Gold Nanoparticle‐Assisted Multiplex Polymerase Chain Reaction Assay for Selected Hospital‐Acquired Infections‐Associated Bacterial and Fungal Pathogens

ChemistryOpen, Volume 15, Issue 9, September 2026.
Gold nanoparticle‐assisted multiplex PCR enables the simultaneous detection of six major hospital‐acquired infection‐associated pathogens by improving amplification performance and assay specificity, providing an analytical proof‐of‐concept for rapid molecular identification.
Kubra Aslan, Emre Erden Kopar, Serap Evran   +2 more
wiley   +1 more source

A Catalogue of Dispensation Lengths for Building Treatment Episodes—Application of the Waiting Time Distribution to All Commonly Prescribed Drugs in Denmark

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Background In pharmacoepidemiologic research, correct assignment of the length of single dispensation is critical to build treatment episodes. The parametric reverse waiting time distribution (rWTD) is a particularly attractive data‐driven method to estimate dispensation lengths.
Mette Reilev, Lotte Rasmussen, Jonas Kanstrup Olsen, Martin Thomsen Ernst, Saad Hanif Abbasi, Rikke Wesselhoeft, Mette Bliddal, Jesper Hallas, Henrik Støvring   +8 more
wiley   +1 more source

Structural and Kinetic Basis for the Rational Design of Next-Generation β-Lactamase Inhibitors. [PDF]

J Med Chem
Chen S, Yu M, Xu M, Decherchi S, Taracila MA, Hujer AM, Bethel CR, Bonomo RA, Haider S.   +8 more
europepmc   +1 more source