Results 91 to 100 of about 1,489,579 (226)
Effect of a β-lactamase inhibitor, tazobactam, on growth and penicillin-binding proteins ofBorrelia burgdorferi [PDF]
FEMS Microbiology Letters, 1991 Carl Urban +2 more
openaire +1 more source
, 2022 ObjectivesThe addition of novel β-lactamase inhibitors to carbapenems restores the activity against multidrug-resistant Gram-negative bacteria. The aim of this study was to summarize the evidence on the efficacy and safety of novel carbapenem–β-lactamase
Wei Yu (43094) +4 more
core +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim We retrospectively evaluated trends in antimicrobial resistance (AMR) in paediatric bloodstream infections and assessed changes in antimicrobial prescription patterns over a 20‐year period. Methods We analysed positive blood cultures from children admitted with suspected serious infection between 1998 and 2018.
Joachim Luthander +5 more
wiley +1 more source
, 2016 KPC β-lactamases hydrolyze the “last resort” β-lactam antibiotics (carbapenems) used to treat multidrug resistant infections and are compromising efforts to combat life-threatening Gram-negative bacterial infections in hospitals worldwide.
James M. Berger (21890) +4 more
core +1 more source
Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)
Australian Veterinary Journal, EarlyView.Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Enhancement effects of antimicrobial activities of β-lactam antibiotics by combination with persimmon tannin against β-lactamase-producing Staphylococcus aureus [PDF]
, 2010 Background β-lactamase-producing Staphylococcus aureus is one of the most important bacterial pathogens. Combinations of β-lactam antibiotics with β-lactamase inhibitors such as sulbactam and tazobactam are useful therapeutic methods for combating ...
Yamada, Akira +7 more
core
, 2022 ObjectivesThe addition of novel β-lactamase inhibitors to carbapenems restores the activity against multidrug-resistant Gram-negative bacteria. The aim of this study was to summarize the evidence on the efficacy and safety of novel carbapenem–β-lactamase
Wei Yu (43094) +4 more
core +1 more source
European Journal of Oral Sciences, EarlyView.Abstract This nationwide register‐based study aimed to investigate trends and regional variation in the number of antibiotic prescriptions issued by dentists in Finland from 2012 to 2025. Data on reimbursed outpatient antibiotic prescriptions dispensed by Finnish pharmacies were used.
Terhi Laitala +4 more
wiley +1 more source
Prediction of Antibiotic Influence by Presence of Some β-lactamase Gene in AcinetobacterInfected Patients Hospitalized in Tehran, Iran [PDF]
Acinetobacter baumannii which is gram-negative rod and infecting hospitalized patient often develops multiple drug resistance patterns and causes serious problem in treatment.
نیاکان, محمد +8 more
core +1 more source