Results 111 to 120 of about 1,489,579 (226)

Sodium deoxycholate synergistically enhances the antimicrobial activity of β-lactam antibiotics againstβ-lactamase-producing Staphylococcus aureus [PDF]

, 2012
Background β-lactamase-producing Staphylococcus aureus synthesizes a β-lactamase which decomposes the β-lactam ring, and consequently almost all β-lactam antibiotics are inactivated by the enzyme. The appearance of β-lactamase-producing bacterial strains
Yamada, Akira, Yoshida, Sayuri, Yaegashi, Asaka, Fujii, Yuichi, Hirano, Kano, Nozawa, Koohei, Tanaka, Satomi, Yamaki, Fumiko, Horie, Hitoshi   +8 more
core  

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source

Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era

Transplant Infectious Disease, EarlyView.
ABSTRACT Background Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center. Methods We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023.
Lana Hasan, Nabin K. Shrestha, Mathew Duck, Joshua Augustine, Richard Fatica, Alvin Wee, Christine E. Koval   +6 more
wiley   +1 more source

Bacterial Diseases in Farmed Nile Tilapia (Oreochromis niloticus): A Review of Pathogenesis, Immune Responses and Recent Advances in Diagnostics and Management

Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
Pathogenesis of bacterial diseases in Nile tilapia and anti‐bacterial mechanisms. ABSTRACT Nile tilapia (Oreochromis niloticus) is among the most widely farmed fish globally that plays a major role in ensuring food security in many low‐ and middle‐income countries.
Catherine Agoe, John Walakira, Gerald Kwikiriza, Nasser Kasozi, Ivan Abaho, Manuel Curto, Paul Meulenbroek, Harald Meimberg, Peter Akoll   +8 more
wiley   +1 more source

A Concise Synthesis of a β-Lactamase Inhibitor

, 2016
MK-7655 (1) is a β-lactamase inhibitor in clinical trials as a combination therapy for the treatment of bacterial infection resistant to β-lactam antibiotics.
Mark A. Huffman (1601572), Nelo Rivera (1601731), Ian K. Mangion (1814908), Rebecca T. Ruck (1436683), Michael Shevlin (1392781)   +4 more
core   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 871-889, October 2026.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

Molecular pharmacodynamics of amoxicillin-clavulanic acid for urinary tract infections caused by Escherichia coli

Nature Communications
Amoxicillin-clavulanic acid (AMX-CLV) is a widely used oral β-lactam/β-lactamase inhibitor combination against Escherichia coli. Clinical success is largely confined to urinary tract infections.
Vineet Dubey, Christopher Darlow, Alessandro Gerada, Jennifer Unsworth, Esha Sheth, Nada Reza, Nicola Farrington, Sam Haldenby, Daniel Warren, Xuan Liu, Alexander Howard, William Hope   +11 more
doaj   +1 more source

IID572: A New Potentially Best-In-Class β‑Lactamase Inhibitor

, 2019
Resistance in Gram-negative bacteria to β-lactam drugs is mediated primarily by the expression of β-lactamases, and co-dosing of β-lactams with a β-lactamase inhibitor (BLI) is a clinically proven strategy to address resistance. New β-lactamases that are
Shaul, Jacob, Dita Rasper (6518135), Robert L. Simmons (1730614), Anthony Casarez (6518117), Blais, Johanne, Luis Gamboa (6518123), Alun Bermingham (2413702), Growcott, Ellena, Lopez, Sara, Tashiro, Kyuto, Sandro Nocito (4516072), Flavio Ossola (1909075), Rasper, Dita, Louis Metzger (6518129), Shen, Xiaoyu, Jacob Shaul (6518138), Dazhi Tang (6017072), Cindy Li (4715433), Kaci Phizackerley (6518132), Metzger, Louis, Folkert Reck (2694517), Charles R. Dean (308355), Colvin, Richard, Simmons, Robert L, Johanne Blais (3417245), Cazarez, Anthony, Phizackerley, Kaci, Nocito, Sandro, Dean, Charles, Reck, Folkert, Bermingham, Alun, Sara Lopez (2675767), Yue, Qin, Ossola, Flavio, Markus Furegati (1730608), Xiaoyu Shen (4715430), Kyuto Tashiro (6518141), Furegati, Markus, Li, Cindy, Qin Yue (1505008), Richard Colvin (6518120), gamboa, Luis, Tang, Dazhi, Ellena Growcott (6518126)   +43 more
core   +1 more source

Overwhelming Post‐Splenectomy Sepsis From Capnocytophaga canimorsus

International Journal of Laboratory Hematology, EarlyView.
Maitlyn Hsia, Maud Ahmad, Cyrus C. Hsia, Benjamin Chin‐Yee   +3 more
wiley   +1 more source

Effect of Green‐Synthesized Silver Nanoparticles From Nepeta pogonosperma and Astrodaucus persicus on the Reduction of Bap Gene Expression in Strong Biofilm‐Producing Acinetobacter baumannii Clinical Isolates

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Green‐synthesized silver nanoparticles from Nepeta pogonosperma and Astrodaucus persicus significantly inhibit biofilm formation and downregulate bap gene expression in multidrug‐resistant clinical isolates of Acinetobacter baumannii. This eco‐friendly approach offers a promising strategy to combat antimicrobial resistance.
Maedeh Kakavan, Mehrdad Gholami, Mohammad Ahanjan, Mohammad Ali Ebrahimzadeh, Abolfazl Hossein Nataj, Tahoora Mousavi, Hamid Reza Goli   +6 more
wiley   +1 more source