Results 131 to 140 of about 33,392 (201)

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

Frontiers in Pharmacology
The rise of β-Lactamase mediated antibiotic resistance is a major concern for public health; hence, there is an urgent need to find new treatment approaches.
Moyad Shahwan, Moyad Shahwan, Mohd Shahnawaz Khan, Azna Zuberi, Nojood Altwaijry, Anas Shamsi   +5 more
doaj   +1 more source

Asp-120 Locates Zn2 for Optimal Metallo-β-lactamase Activity [PDF]

, 2007
Metallo-β-lactamases are zinc-dependent hydrolases that inactivate β-lactam antibiotics, rendering bacteria resistant to them. Asp-120 is fully conserved in all metallo-β-lactamases and is central to catalysis.
Bennett, Brian, Fabiane, Stella M., Kowalski, Jason M., Llarrull, Leticia l., Sutton, Brian J., Vila, Alejandro J.   +5 more
core   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters

ACS Omega, 2022
Katarzyna Palica, Manuela Vorácová, Susann Skagseth, Anna Andersson Rasmussen, Lisa Allander, Madlen Hubert, Linus Sandegren, Hanna-Kirstirep Schrøder Leiros, Hanna Andersson, Máté Erdélyi   +9 more
doaj   +1 more source

Drug Discovery in the Field of β-Lactams: An Academic Perspective

Antibiotics
β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis.
Lian M. C. Jacobs, Patrick Consol, Yu Chen   +2 more
doaj   +1 more source

Comprehensive screening of potential inhibitors from ZINC15 database for Metallo-L1 Β -Lactamase from Stenotrophomonas maltophilia via in Silico and in vitro approaches

BMC Microbiology
Background Antibiotic resistance caused by pathogenic microbes have become a serious issue in health field as most of the antibiotics discovered are rendered ineffective for the treatment of numerous microbial infections.
K H Sreenithya, Salim Manoharadas, Shobana Sugumar   +2 more
doaj   +1 more source

Resistance of Gram-Negative Bacteria to Cefepime-Enmetazobactam: A Systematic Review

Pathogens
Cefepime-enmetazobactam is a novel β-lactam/β-lactamase inhibitor combination showing good activity against multidrug-resistant (MDR) Gram-negative bacteria producing a variety of β-lactamases.
Matthew E. Falagas, Laura T. Romanos, Dimitrios S. Kontogiannis, Katerina Tsiara, Stylianos A. Kakoullis   +4 more
doaj   +1 more source

Divalent Metal Binding Properties of the Methionyl Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 2000
The metal-binding properties of the methionyl aminopeptidase from Escherichia coli (MetAP) were investigated. Measurements of catalytic activity as a function of added Co(II) and Fe(II) revealed that maximal enzymatic activity is observed after the ...
Bennett, Brian, Copik, Alicja J., D\u27Souza, Ventris M., Holz, Richard C.   +3 more
core   +1 more source

Efficacy and safety of novel β-lactam/β-lactamase inhibitor combinations for the treatment of complicated urinary tract infections or acute pyelonephritis: A systematic review and meta-analysis

Journal of Global Antimicrobial Resistance
Objectives: The increasing resistance of gram-negative bacteria in complicated urinary tract infections (cUTI) and acute pyelonephritis (APN) poses major treatment challenges.
Sirui Tang, Yuxuan Song, Caipeng Qin, Tao Xu   +3 more
doaj   +1 more source

Revitalizing cephalosporins: The promise of β-lactamase inhibitor combinations. [PDF]

GMS Hyg Infect Control
Marzooka KC, Sajed S, Dehghan MH, Bilal K, Imaan R.   +4 more
europepmc   +1 more source