Results 61 to 70 of about 14,756 (172)

Green Synthesis of ZnO Nanoparticles From Spirulina platensis: Antimicrobial and Cytotoxic Evaluation With Molecular Docking Studies

ChemistryOpen, EarlyView.
Algal‐extract‐derived ZnO nanoparticles show shape anisotropy and are bio capped by phytochemicals. These green‐synthesized NPs strongly inhibit S. aureus and K. pneumoniae biofilms. Molecular docking suggests stable binding of surface biomolecules to microbial targets, highlighting synergistic antibacterial mechanisms.
Muhammad Rizwan, Izaz Khan, Syed Sikandar Shah, Amir hamza khan, Abdurahman Hajinur Hirad, Saira Naz, Arshad Farid, Taimoor Khan, Said Hassan   +8 more
wiley   +1 more source

Interfacial Chemistry‐Tailored Silica&Metal‐Based Heterostructures: from Rational Design to Antibacterial Applications

Small, EarlyView.
This review explores how interfacial engineering of silica&metal‐based nanohybrids enables precise architectural control, leveraging the structural and functional contributions of silica to overcome the inherent limitations of meta‐based materials. The antibacterial performance of these nanohybrids including membrane disruption, stimuli‐responsive ...
Dan Cheng, Yuchao Gu, Chengzhong Yu
wiley   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians

Veterinary Record, EarlyView.
Abstract Background A structured, behavioural science approach was adopted to develop antimicrobial stewardship interventions in UK first‐opinion companion animal veterinary practice. The objectives were to identify behavioural targets for intervention and to understand how practice contexts influence these behaviours.
Ben Walker, Dan O'Neill, Huw Stacey, Dave Brodbelt   +3 more
wiley   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors

Alimentary Pharmacology &Therapeutics, EarlyView.
This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen, Sarah L. Schütte, Tammo L. Tergast, Benjamin Maasoumy, Leonie Braun, Ulrich vor dem Esche, Georg Häcker, Marcus M. Mücke, Marlene Reincke, Michael Schultheiss, Robert Thimme, Siegbert Rieg, Dominik Bettinger, Lukas Sturm   +13 more
wiley   +1 more source

Time-resolved crystallography of boric acid binding to the active site serine of the β-lactamase CTX-M-14 and subsequent 1,2-diol esterification

Communications Chemistry
The emergence and spread of antibiotic resistance represent a growing threat to public health. Of particular concern is the appearance of β-lactamases, which are capable to hydrolyze and inactivate the most important class of antibiotics, the β-lactams ...
Andreas Prester, Markus Perbandt, Marina Galchenkova, Dominik Oberthuer, Nadine Werner, Alessandra Henkel, Julia Maracke, Oleksandr Yefanov, Johanna Hakanpää, Guillaume Pompidor, Jan Meyer, Henry Chapman, Martin Aepfelbacher, Winfried Hinrichs, Holger Rohde, Christian Betzel   +15 more
doaj   +1 more source

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

BJU International, EarlyView.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon, Asaad Ahmad, Natalie Lott, Alison Blatt   +3 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) 2025 guidelines for surgical antimicrobial prophylaxis in dogs and cats

Journal of Small Animal Practice, EarlyView.
Surgical antimicrobial prophylaxis involves the administration of antimicrobials to reduce the risk of a surgical site infection and represents a significant proportion of all antimicrobial use in cats and dogs. This evidence‐based, European Network for Optimization of Veterinary Antimicrobial Therapy guideline provides recommendations for both peri ...
F. Allerton, T. M. Sørensen, K. Scahill, J. E. Ruperez, F. Swinbourne, D. R. Verwilghen, M. C. Nolff, F. Foroutan, S. J. Baines, A. Vilen, L. Pelligand, E. M. Broens, P. L. Toutain, M. L. Brennan, T. Mooney, S. Clarke, J. E. Miles, J. L. Granick, Y. Winsborg, L. R. Jessen, J. S. Weese, on behalf of the European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines and the ESCMID Study Group for Veterinary Microbiology (ESGVM)   +21 more
wiley   +1 more source