Results 81 to 90 of about 1,471,936 (197)

Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)

Australian Veterinary Journal, EarlyView.
Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

A retrospective analysis of bacterial pathogens in wounds in an equine hospital (2017–2022)

Equine Veterinary Education, EarlyView.
Summary Background Bacterial infections are a major cause of morbidity in horses, particularly in soft tissue wounds (STW) and surgical site infections (SSI). Rising antimicrobial resistance poses challenges for timely treatment. Knowledge of common pathogens and their resistance patterns is therefore essential.
J. Nebes, M. Schneeberger, S. Schmitt, J. N. van Spijk   +3 more
wiley   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Time-resolved crystallography of boric acid binding to the active site serine of the β-lactamase CTX-M-14 and subsequent 1,2-diol esterification

Communications Chemistry
The emergence and spread of antibiotic resistance represent a growing threat to public health. Of particular concern is the appearance of β-lactamases, which are capable to hydrolyze and inactivate the most important class of antibiotics, the β-lactams ...
Andreas Prester, Markus Perbandt, Marina Galchenkova, Dominik Oberthuer, Nadine Werner, Alessandra Henkel, Julia Maracke, Oleksandr Yefanov, Johanna Hakanpää, Guillaume Pompidor, Jan Meyer, Henry Chapman, Martin Aepfelbacher, Winfried Hinrichs, Holger Rohde, Christian Betzel   +15 more
doaj   +1 more source

Use of β-Lactam/β-Lactamase Inhibitors for Extended-Spectrum-β-Lactamase Infections: Defining the Right Patient Population

, 2017
In a multicenter, multinational observational study that included neutropenic patients with bloodstream infections by extended-spectrum-β-lactamase-producing species, Gudiol et al. (Antimicrob. Agents Chemother.
Pranita D. Tamma, Maria Virginia Villegas, Villegas, María Virginia, Tamma , Pranita   +3 more
core   +1 more source

Effect of a β-lactamase inhibitor, tazobactam, on growth and penicillin-binding proteins ofBorrelia burgdorferi [PDF]

FEMS Microbiology Letters, 1991
Carl Urban, James J. Rahal, Benjamin Luft   +2 more
openaire   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Extended-spectrum-β-lactamase-positive escherichia coli mainly adds to, rather than replaces, extended-spectrum-β-lactamase-negative e. coli in causing bacteraemia in hong kong, 2000-10

, 2012
Extended-spectrum-β-lactamase-positive escherichia coli mainly adds to, rather than replaces, extended-spectrum-β-lactamase-negative e.
PL Ho (6009764), KH Chow (17321398), EHY Lau (16543686), VCC Cheng (17321404), EL Lai (17321401)   +4 more
core   +1 more source