Results 81 to 90 of about 37,330 (229)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Time-resolved crystallography of boric acid binding to the active site serine of the β-lactamase CTX-M-14 and subsequent 1,2-diol esterification

Communications Chemistry
The emergence and spread of antibiotic resistance represent a growing threat to public health. Of particular concern is the appearance of β-lactamases, which are capable to hydrolyze and inactivate the most important class of antibiotics, the β-lactams ...
Andreas Prester, Markus Perbandt, Marina Galchenkova, Dominik Oberthuer, Nadine Werner, Alessandra Henkel, Julia Maracke, Oleksandr Yefanov, Johanna Hakanpää, Guillaume Pompidor, Jan Meyer, Henry Chapman, Martin Aepfelbacher, Winfried Hinrichs, Holger Rohde, Christian Betzel   +15 more
doaj   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

In vitro activity of cefodizime (HR-221) in combination with β-lactamase inhibitors

, 1993
Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to β-lactamases in the presence of two β- lactamase inhibitors (clavulanic acid, tazobactam).
PERILLI, MARIAGRAZIA, AMICOSANTE, Gianfranco, FRANCESCHINI, Nicola, SEGATORE, Bernardetta, SETACCI, Domenico, ORATORE, Arduino   +5 more
core   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

β‑Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs

, 2019
Infections caused by resistant bacteria are nowadays too common, and some pathogens have even become resistant to multiple types of antibiotics, in which case few or even no treatments are available.
Esther Colchón (7860593), Diana Rodríguez (7860584), Concepción González-Bello (1358856), Ángela Rodríguez (7860590), Marina Pernas (7860587)   +4 more
core   +1 more source

Motion pattern of the complex involved in klebsiella pneumoniae carbapenemases and β-Lactamase inhibitor protein

四川大学学报. 自然科学版, 2017
Carbapenems, used in clinical treatment of multi-drug resistance bacterial infection, can be hydrolyzed by Klebsiella pneumoniae carbapenemases, which weaken the treatment effect of gram negative bacterial infection.
ZUO Ke, DU Wen-Yi, DAI Tian-Yang, LIU Wei, LIANG Li, hujianping   +5 more
doaj  

Proposed Meropenem Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Bacteria Isolated From Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Meropenem is a carbapenem antibiotic used infrequently in veterinary medicine. However, antimicrobial susceptibility testing standards are needed to monitor for resistance caused by carbapenem resistant Enterobacterales (CRE). The Clinical and Laboratory Standards Institute (CLSI) does not have veterinary‐specific carbapenem breakpoints for ...
Mark G. Papich, Marilyn N. Martinez
wiley   +1 more source

N -Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase

, 2002
Members of a family of N -arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence.
Stefan Siemann, Thammaiah Viswanatha, Darryl P. Evanoff, Anthony J. Clarke, Laura Marrone, Gary I. Dmitrienko   +5 more
core   +1 more source

Effect of a β-lactamase inhibitor, tazobactam, on growth and penicillin-binding proteins ofBorrelia burgdorferi [PDF]

FEMS Microbiology Letters, 1991
Carl Urban, James J. Rahal, Benjamin Luft   +2 more
openaire   +1 more source