Results 81 to 90 of about 31,219 (256)

Evolution of Drug Resistance: Insight on TEM β-Lactamases Structure and Activity and β-Lactam Antibiotics [PDF]

, 2014
Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has spread and evolved promoting new resistances to pathogens.
Fernandes, Rúben, Moreira, I. S., Pimenta, A. C.   +2 more
core   +1 more source

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Targeting Class A and C Serine \u3b2-Lactamases with a Broad-Spectrum Boronic Acid Derivative [PDF]

, 2014
Production of \u3b2-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight \u3b2-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent
Alberto Venturelli, Bebrone C., Bennett P. M., Blizzard T. A., Bonnefoy A., Bonnet R., Bradshaw J. M., Brian K. Shoichet, Brunger A. T., Bush K., Bush K., Carter P. J., Cecilia Pozzi, Chaibi E. B., Chen Y., Chen Y., Coleman K., Delmas J., Donatella Tondi, Drawz S. M., Ehmann D. E., Emsley P., Farina D., Hirsch E. B., Hunter C. A., Ibuka A., Jacoby G. A., Kettner C. A., Laskowski R. A., Lovell S. C., Majumdar S., Marciano D. C., Maria Paola Costi, Morandi F., Murshudov G. N., Ness S., Nichols D. A., Otwinowski Z. M., Pages J. M., Potterton E., Powers R. A., Powers R. A., Richard Bonnet, Robin F., Roth T. A., Strynadka N. C., Strynadka N. C. J., Strynadka N. C. J., Thornton J. M., Tondi D., Tondi D., Usher K., Venturelli A., Waley S. G., Wang X., Wang X., Wang X., Willcockson I. U., Winn M. D.   +58 more
core   +3 more sources

Evaluation of Ceftriaxone as a Monotherapy and Amoxicillin With Clavulanic Acid as Combination Therapy in Surgical Prophylaxis

iNew Medicine, EarlyView.
ABSTRACT Surgical antibiotic prophylaxis (SAP) is crucial in preventing postoperative surgical site infections (SSIs), especially in clean and clean‐contaminated surgeries. It was a prospective comparative observational study that compared the effectiveness and safety of single‐dose ceftriaxone monotherapy with amoxicillin–clavulanic acid as a ...
Anayat Ullah, Arsh Ali, Md Nematullah, Suriya Kumar Singh, Anant Singh Paliwal, Najish Parveen   +5 more
wiley   +1 more source

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

Biomolecules, 2020
Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases.
Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem   +12 more
doaj   +1 more source

Bicyclic Boronate β‐Lactamase Inhibitors: The Present Hope against Deadly Bacterial Pathogens [PDF]

, 2021
Emilio Lence, Concepción González‐Bello   +1 more
openalex   +1 more source

Antibacterial Activity of Culture Extracts of Penicillium chrysogenum PCL501: Effects of Carbon Sources [PDF]

, 2009
Penicillium chrysogenum PCL501 produced β-lactam antibiotics when fermented with different agro-wastes: cassava shavings, corncob, sawdust and sugarcane pulp.
Chinedu, SN, Okafor, UA, Okochi, VI, Onyegeme-Okerenta, BM   +3 more
core   +1 more source

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes [PDF]

, 2016
Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs ...
Bonomo, Robert A., Castillo, Valerie, Gonzalez, Javier M., Gonzalez, Mariano M., Hinchliffe, Philip, Kosmopoulou, Magda, Llarrull, Leticia, Mahler, Graciela, Mojica, Maria F., Saiz, Cecilia, Spencer, Jim, Tooke, Catherine, Villa, Alejandro J.   +12 more
core   +3 more sources

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Evaluation of FilmArray Multiplex PCR Test Results in Bloodstream Infections in Oncological Patients

Journal of Clinical Laboratory Analysis, EarlyView.
In this study conducted at an oncology hospital, BCID2 panel results for the rapid identification of microorganisms and resistance genes in positive blood culture samples were compared with conventional culture methods. The BCID2 panel provided faster results and showed a high correlation with traditional methods.
İpek Mumcuoğlu, Sevgi Şahin, Esra Tavukcu, Neşe İnan, Ayşe Semra Güreser, Serap Süzük Yıldız, Tuba Dal   +6 more
wiley   +1 more source