Results 91 to 100 of about 37,330 (229)

Design and synthesis of metallo-β-lactamase inhibitors [PDF]

, 2015
Bacterial resistance is a continuously evolving threat to our most common antibiotics; the β-lactams. Most recently, the production of β-lactamase enzymes by bacteria rendered many of our current antibiotics unusable threatening to plunge us into a ‘pre ...
Cain, Ricky Michael
core  

O-Aryloxycarbonyl Hydroxamates:  New β-Lactamase Inhibitors That Cross-Link the Active Site

, 2016
O-Aryloxycarbonyl hydroxamates represent a new class of β-lactamase inhibitors. N-Benzyloxycarbonyl-O-(phenoxycarbonyl) hydroxylamine, for example, inactivates the class C Enterobacter cloacae P99 β-lactamase with a rate constant of 6.1 × 103 s-1 M-1 ...
Kerim Babaoglu (1648204), Ryan B. Pelto (2244361), Brian K. Shoichet (434829), Pauline N. Wyrembak (2381788), R. F. Pratt (1340403)   +4 more
core   +1 more source

Diversity and proliferation of metallo-β-lactamases : a clarion call for clinically effective metallo-β-lactamase inhibitors [PDF]

, 2018
The worldwide proliferation of life-threatening metallo-β-lactamase (MBLs)-producing Gram-negative bacteria is a serious concern to public health. MBLs are compromising the therapeutic efficacies of β-lactams, particularly carbapenems, which are last ...
Osei Sekyere, John, Essack, Sabiha Y., Bester, Linda A., Amoako, Daniel G., Somboro, Anou M.   +4 more
core   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Exploring the Inhibition of CTX-M-9 by β-Lactamase Inhibitors and Carbapenems

, 2011
Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors.
Andrea Endimiani, Jodi M. Thomson, Anne M. Distler, Magdalena Taracila, Richard Bonnet, Robert A. Bonomo, Krisztina Papp-Wallace, Kristine M. Hujer, Christopher R. Bethel, Teresa Shyr, Andrea M. Hujer   +10 more
core   +1 more source

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source

Structure-Based Approach for Binding Site Identification on AmpC β-Lactamase

, 2016
β-Lactamases are the most widespread resistance mechanism to β-lactam antibiotics and are an increasing menace to public health. Several β-lactamase structures have been determined, making this enzyme an attractive target for structure-based drug design.
Rachel A. Powers (1345839), Brian K. Shoichet (434829)   +1 more
core   +1 more source

Highly efficient β-lactamase assay applying Poly-Dimethylacrylamide-based surface functionalization with β-lactam antibiotics and β-lactamase inhibitors

, 2023
51205130In recent decades, the rise of β-lactamases has substantially led to the emergence and wide spread of antibiotic resistance posing a serious global health threat.
Borgolte, Max, Filbert, Alexander, Laufer, Stefan, Rentschler, Simone, Deigner, Hans-Peter   +4 more
core   +1 more source

Serious Bacterial Infections in Hospitalized Neonates in Eastern Ethiopia: Investigating the Emerging Pathogen Pantoea dispersa Compared With Klebsiella pneumoniae

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Serious bacterial infections (SBIs) are major contributors to neonatal morbidity and mortality in low‐income countries. We describe the aetiology and risk factors for neonatal bacteraemia and in‐hospital mortality in eastern Ethiopia, focusing on Pantoea dispersa, a rarely studied pathogen, and Klebsiella pneumoniae.
Yunus Edris, Faisel A. Hassen, Desalegn A. Ayana, Fami Ahmed, Haleluya Leulseged, Dadi Marami, Jabir Aliye, Belete G. Alem, Zelalem T. Mariam, Gezahang Mengesha, Nega Assefa, Alexander M. Aiken, J. Anthony G. Scott, Lola Madrid   +13 more
wiley   +1 more source

Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase

, 1998
Background: High level resistance to carbapenem antibiotics in gram negative bacteria such as Bacteroides fragilis is caused, in part, by expression of a wide-spectrum metallo-β-lactamase that hydrolyzes the drug to an inactive form. Co-administration of
Olson, Steven H., Sundelof, Jon G., Cleary, Kelly A., Grant, Stephan K., Hammond, Gail G., Fitzgerald, Paula M.D., Kozarich, John W., May, Walter J., Toney, Jeffrey H., Grover-Sharma, Nandini, Vanderwall, Dana E., Wu, Joseph K., Pompliano, David L.   +12 more
core   +1 more source