Results 101 to 110 of about 37,330 (229)

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

Protein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source

β-lactamase inhibitors.

, 2014
(A) Chemical structures for SA-2-13, PSR-4-157, PSR-4-155, and PSR-3-226. The ring atoms of SA2-13 are numbered to indicate the position of the C2 carboxyl linker and C3 carboxyl groups. (B) Proposed β-lactamase inhibition reaction scheme for SA2-13.
John D. Buynak (299562), Elizabeth A. Rodkey (510008), Focco van den Akker (158508), Marisa L. Winkler (510009), Christopher R. Bethel (299558), Robert A. Bonomo (188763), Sundar Ram Reddy Pagadala (510010)   +6 more
core   +1 more source

: Exploration of Potential Metallo-β-Lactamase Inhibitors [PDF]

, 2019
Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use.
Khan, René, Essack, Sabiha Y., Hezekiel M. Kumalo, John Osei Sekyere, Osei Sekyere, John, René Khan, Kumalo, Hezekiel M., Anou M. Somboro, Bester, Linda A., Linda A. Bester, Daniel G. Amoako, Sabiha Y. Essack, Amoako, Daniel G., Somboro, Anou M.   +13 more
core   +1 more source

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

BJU International, Volume 138, Issue 1, Page 33-44, July 2026.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon, Asaad Ahmad, Natalie Lott, Alison Blatt   +3 more
wiley   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic‐Sparing Strategies

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Antimicrobial resistance (AMR) is a growing challenge in veterinary ophthalmology, particularly in cases of bacterial keratitis, where progressive stromal infection can threaten vision and globe integrity within hours to days. This review synthesizes current evidence on pathogen distribution, antimicrobial susceptibility profiles, multidrug ...
Lionel Sebbag, Oren Pe'er
wiley   +1 more source

Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1

, 2017
Background. The emergence of bacterial strains resistant to available antibiotic armamentarium is nowadays a pressing issue in clinical therapy. Among the several mechanisms of bacterial resistance, the rapid evolution and spread of carbapenemases, β ...
Cross, Simon, Perilli, Mariagrazia, Celenza, Giuseppe, Cendron, Laura, TONDI, Donatella, Bellio, Pierangelo, SPYRAKIS, FRANCESCA, Marcoccia, Francesca   +7 more
core  

Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase

, 2001
Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-β-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II).
Page, Michael I., Laws, Andrew P., Bounaga, Sakina, Bounaga, S., Galleni, Moreno, Laws, A. P., Page, M. I.   +6 more
core   +1 more source

Sulbactam-durlobactam improves cephalosporin and carbapenem susceptibility and time-kill effect against Mycobacterium abscessus

Microbiology Spectrum
Despite the long therapy duration, the treatment outcomes for Mycobacterium abscessus lung disease (MAB-LD) are very poor. β-Lactams are among the recommended drugs for the treatment of MAB-LD; however, they are prone to hydrolysis by MAB β-lactamase ...
Avneesh Shrivastava, Gunavanthi D. Boorgula, Sanjay Singh, Danaleigh Stiles, Pamela J. McShane, Megan Devine, Tawanda Gumbo, Shashikant Srivastava   +7 more
doaj   +1 more source

Antibacterial Activity of Heteropolytungstates Against Proteus mirabilis

European Journal of Inorganic Chemistry, Volume 29, Issue 18, 22 June 2026.
We investigated the in vitro antibacterial activity of several heteropolytungstates against P. mirabilis, a drug‐resistant pathogen. All tested polyanions inhibited bacterial growth, with the Preyssler–Pope–Jeannin polyanion P5W30 exhibiting the highest activity (MIC = 0.78 mg/mL).
Nour El Ghouch, Ahmad Asaad, Rana El Hajj, Sahar Khandan, Matthias S. Ullrich, Ulrich Kortz   +5 more
wiley   +1 more source