Results 121 to 130 of about 1,471,936 (197)

Phytochemical Profiling and Antibacterial Activity of Moroccan Monofloral Honeys Against Multidrug‐Resistant Uropathogens: In Vitro, ADMET, Molecular Docking, and Molecular Dynamics Approaches

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Multidrug‐resistant bacteria infections require alternative antimicrobial strategies. This study evaluated the phenolic composition, antibacterial activity, and in silico properties of four Moroccan monofloral honeys. Carob honey showed the greatest phenolic diversity, whereas citrus honey contained the lowest polyphenolic content.
Mourad Chikhaoui, Aziz Galman, Ahmed Chetoui, Oussama Khibech, Mohamed Reda Kachmar, Toufik Bouddine, Mohamed Bouhrim, Fahd A. Nasr, Mohammed Al‐Zharani, Ashraf Ahmed Qurtam, Rachid Lotfi, Houda El Hajjouji   +11 more
wiley   +1 more source

Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1

, 2017
Background. The emergence of bacterial strains resistant to available antibiotic armamentarium is nowadays a pressing issue in clinical therapy. Among the several mechanisms of bacterial resistance, the rapid evolution and spread of carbapenemases, β ...
Cross, Simon, Perilli, Mariagrazia, Celenza, Giuseppe, Cendron, Laura, TONDI, Donatella, Bellio, Pierangelo, SPYRAKIS, FRANCESCA, Marcoccia, Francesca   +7 more
core  

A Disproportionality Analysis of β‐lactam Antibiotic Related Blood and Lymphatic System Disorders Based on the FDA Adverse Event Reporting System Database

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims β‐lactam antibiotics stand as the most profoundly impactful classes of antibacterial agents worldwide. Their widespread application has raised safety concerns over adverse events (AEs), such as blood and lymphatic system disorders (BLSDs).
Jing Liu, Min Zhang, Zongwei Tang, Xiaoxiao Wang, Li Mu, Wanyi Chen, Haichi Song   +6 more
wiley   +1 more source

In vitro activity of aztreonam in combination with relebactam against gram-negative pathogens producing various serine and metallo-β-lactamases

Journal of Global Antimicrobial Resistance
Objectives: Infections caused by carbapenemase-producing Gram-negative pathogens have become a significant global public health challenge due to limited treatment options.
Kengo Hayashi, Masahiro Suzuki, Yoshikazu Ishii, Yasufumi Matsumura, Kazuaki Matsumoto, Sho Saito, Yohei Doi   +6 more
doaj   +1 more source

Dose Selection for Ceftibuten Combined with Avibactam Tomilopil, a Potential Oral Alternative to Carbapenems for Patients with Complicated Urinary Tract Infections

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract There are currently no oral treatment options for infections caused by extended spectrum β‑lactamase‐producing Enterobacterales. Avibactam tomilopil, a novel oral prodrug of avibactam, is being developed in combination with the oral cephalosporin, ceftibuten, as a potential treatment for patients with complicated urinary tract infections ...
Siddhee A. Sahasrabudhe, Satoshi Shoji, Abhijeet S. Jakate, Bisrat K. Abraham, Sima S. Toussi, Benjamin J. Maligalig, Amanda S. Darekar, Sakambari Tripathy, Constantino Kantaridis, Josue K. Mfopou, Oxana Selivanova, Arthur Bergman, Negar Niki Alami, Ravi Shankar P. Singh   +13 more
wiley   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, Volume 57, Issue 9, Page 1554-1564, September 2026.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

In vitro activity of cefodizime (HR-221) in combination with β-lactamase inhibitors

, 1993
Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to β-lactamases in the presence of two β- lactamase inhibitors (clavulanic acid, tazobactam).
PERILLI, MARIAGRAZIA, AMICOSANTE, Gianfranco, FRANCESCHINI, Nicola, SEGATORE, Bernardetta, SETACCI, Domenico, ORATORE, Arduino   +5 more
core   +1 more source

Sulbactam–Durlobactam: A Novel Antibiotic Combination for the Treatment of Acinetobacter baumannii–Calcoaceticus Complex (ABC) Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia

Canadian Journal of Infectious Diseases and Medical Microbiology
Summary: Sulbactam–durlobactam is a recently approved antimicrobial combination of two β-lactamase inhibitors for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) associated with ...
Wissam K. Kabbara, Elina Sadek, Hanine Mansour   +2 more
doaj   +1 more source

A Catalogue of Dispensation Lengths for Building Treatment Episodes—Application of the Waiting Time Distribution to All Commonly Prescribed Drugs in Denmark

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Background In pharmacoepidemiologic research, correct assignment of the length of single dispensation is critical to build treatment episodes. The parametric reverse waiting time distribution (rWTD) is a particularly attractive data‐driven method to estimate dispensation lengths.
Mette Reilev, Lotte Rasmussen, Jonas Kanstrup Olsen, Martin Thomsen Ernst, Saad Hanif Abbasi, Rikke Wesselhoeft, Mette Bliddal, Jesper Hallas, Henrik Støvring   +8 more
wiley   +1 more source