Results 131 to 140 of about 37,330 (229)

Antibiotic Resistance Profile of Wound Infection Isolates: High Resistance to Cephalosporins and Penicillin Among Ghanaian Patients in a Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim Antibiotics remain among the most frequently prescribed medications in clinical practice. However, antimicrobial resistance (AMR) is an inevitable and irreversible consequence of bacterial adaptation to antimicrobial exposure.
Nelson Kwashie, Samuel Antwi‐Baffour, Lawrence Annison, Lydia Ofosua Appah, Uwakmfon Paul, Solomon Akpobi, Ebenezer Senu   +6 more
wiley   +1 more source

Development of novel phosphonic acid-type metallo-β-lactamase inhibitors

The Global Antibiotic Research & Development Partnership (GARDP) estimates that antibiotic resistance claims one life in every 6 seconds. Antibiotic resistance is already associated with 5 million deaths annually, and this number continues to rise. A
Rosenström, Ulrika,, Erdélyi, Máté,, Gulyás, Kinga Virág,   +2 more
core  

Genomic epidemiology and lineage‐specific risk stratification of tet(X4)‐mediated tigecycline resistance along the pork production chain: A One Health perspective

iMetaOmics, Volume 3, Issue 2, June 2026.
Genome surveillance across a swine‐associated One Health continuum in China shows that slaughterhouses act as major enrichment nodes for tet(X4)‐mediated tigecycline resistance, driven by putative clonal transmission and stable plasmid backbones. Integrating global datasets enables lineage‐specific risk stratification, highlighting key control points ...
Qin Wang, Qiwu Yuan, Xuan Chen, Yujing Zhong, Ke Wu, Renqiao Wen, Luya Liu, Xiaoqin Wang, Cui Li, Hongning Wang, Changwei Lei   +10 more
wiley   +1 more source

Binding Properties of a Peptide Derived from β-Lactamase Inhibitory Protein

, 2001
To overcome the antibiotic resistance mechanism mediated by β-lactamases, small-molecule β-lactamase inhibitors, such as clavulanic acid, have been used.
Wanzhi Huang, Timothy Palzkill, Gary W. Rudgers   +2 more
core   +1 more source

Sulbactam–Durlobactam: A Novel Antibiotic Combination for the Treatment of Acinetobacter baumannii–Calcoaceticus Complex (ABC) Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia

Canadian Journal of Infectious Diseases and Medical Microbiology
Summary: Sulbactam–durlobactam is a recently approved antimicrobial combination of two β-lactamase inhibitors for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) associated with ...
Wissam K. Kabbara, Elina Sadek, Hanine Mansour   +2 more
doaj   +1 more source

Anterolateral‐Thigh Fascia Lata Free Flap Versus Fibula Free Flap for Mandibular Osteoradionecrosis

The Laryngoscope, Volume 136, Issue 6, Page 2565-2572, June 2026.
The anterolateral thigh fascia lata “rescue” free flap has been employed as a novel tool in the treatment of advanced partial thickness mandibular osteoradionecrosis. Compared with the traditional fibula free flap for the same indication, the “rescue” flap provides similar outcomes in terms of disease resolution, superior functional outcomes, and ...
Conrad K. Blunck, Alexander Havens, Michael A. Fritz, Brandon L. Prendes, Derek J. Vos, Amani Alvi, Sara Liu, Dane J. Genther, Peter J. Ciolek   +8 more
wiley   +1 more source

Clinical role of β-lactam/β-lactamase inhibitor combinations

, 2003
The use of β-lactamase inhibitors in combination with β-lactam antibiotics is currently the most successful strategy to combat a specific resistance mechanism.
Lee, N, Kumana, CR, Yuen, KY
core   +1 more source

Gut Microbiota as a Key Modulator in the Pathophysiology of Sepsis: SURVEIL Project

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Longitudinal profiling of 132 hospitalized patients reveals that age, colonization status, and sepsis interact to shape gut microbiota diversity and composition. Sepsis is associated with reduced alpha diversity, beta‐diversity shifts, functional predictions (methanogenesis, nitrate/sulfate respiration), and partial MDR overlap with bloodstream ...
Chiara Bazzano, Alice Caramaschi, Nadia Massa, Silvio Collani, Marta Mellai, Nadia Barizzone, Andrea Rocchetti, Paolo Bottino, Maria Simona Caroppo, Valeria Bonato, Rosanna Vaschetto, Sara Scaglione, Alessia Francese, Narges Gholami, Claudio Caria, Paola Bianchi, Cristiano Lauritano, Luigi Castello, Annalisa Roveta, Antonio Maconi, Stefano Andreoni, Sandra Dalfonso, Elisa Bona   +22 more
wiley   +1 more source

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Optimization of β-Lactam/β-Lactamase Inhibitor Dosing

, 2020
Infections caused by extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria are associated with increased mortality and cost of care.
Abodakpi, Henrietta Dzigbordi
core