Results 131 to 140 of about 1,471,936 (197)

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source

Antibacterial Effect of the In Vitro Interaction Between Clotrimazole and Chlorhexidine Against Staphylococcus pseudintermedius With Known Resistance Patterns Isolated From Canine Pyoderma

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
The 2:1 chlorhexidine–clotrimazole combination demonstrated enhanced antibacterial activity against canine Staphylococcus pseudintermedius isolates, including resistant strains. Reduced MIC values, predominantly additive interactions and absence of antagonism support its use as a promising topical strategy for canine pyoderma management.
Brenda Gallegos‐Torres, Edgar Alfonseca‐Silva, Claudia Ledesma‐Carrasco, Itzcoatl Aquino‐Díaz   +3 more
wiley   +1 more source

Prevalence and Genomic Characterization of mcr‐Positive Enterobacteriaceae in Retail Meat in Thailand Following the Colistin Ban

Microbiology and Immunology, Volume 70, Issue 9, Page 402-415, September 2026.
ABSTRACT This study aimed to investigate the prevalence and characteristics of mcr‐positive Enterobacteriaceae in retail meat in Thailand following the national ban on prophylactic colistin use in food producing animals. A total of 152 meat samples (103 chicken and 49 pork) were collected from supermarkets and open markets between July and September ...
Ahmed Abououf, Sharda Prasad Awasthi, Asmaa M. Elbastawesy, Noritoshi Hatanaka, Atsushi Hinenoya, Srinuan Somroop, Yukihiro Kaneko, Shinji Yamasaki   +7 more
wiley   +1 more source

Restoring Meropenem Activity Against VIM‐1‐Producing Klebsiella pneumoniae Through Zinc‐Binding Ligands

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa, Ruqaiya Khalil, Valentina Giglio, Kaveh Eskandari, Fraser J. Scott, Attilio V. Vargiu, Graziella Vecchio   +6 more
wiley   +1 more source

Development of novel phosphonic acid-type metallo-β-lactamase inhibitors

The Global Antibiotic Research & Development Partnership (GARDP) estimates that antibiotic resistance claims one life in every 6 seconds. Antibiotic resistance is already associated with 5 million deaths annually, and this number continues to rise. A
Rosenström, Ulrika,, Erdélyi, Máté,, Gulyás, Kinga Virág,   +2 more
core  

Synthesis of novel serine β-lactamase inhibitors

The widespread emergence of bacterial resistance to β-lactam antibiotics, driven primarily by serine β-lactamases (SBLs), continues to threaten the clinical utility of this cornerstone class of antibacterial agents.
Ho, Justin Young
core   +1 more source

Rational Design, Synthesis, and Biological Evaluation of New Substituted Dihydropyrimidinones as Antibacterial Agents and β-Lactamase Inhibitors. [PDF]

Chem Biol Drug Des
Soliman AM, Allam HA, Mahmoud WR, Naguib BH.   +3 more
europepmc   +1 more source

Structural and Kinetic Basis for the Rational Design of Next-Generation β-Lactamase Inhibitors. [PDF]

J Med Chem
Chen S, Yu M, Xu M, Decherchi S, Taracila MA, Hujer AM, Bethel CR, Bonomo RA, Haider S.   +8 more
europepmc   +1 more source

The in vitro effect of new combinations of carbapenem-β-lactamase inhibitors for Mycobacterium abscessus. [PDF]

Antimicrob Agents Chemother, 2023
Fröberg G, Ahmed A, Chryssanthou E, Davies Forsman L.   +3 more
europepmc   +1 more source

A Semester-Long Laboratory in Molecular Biology and Biochemistry Focusing on the Discovery of Novel β-Lactamase Inhibitors From Streptomyces. [PDF]

Biochem Mol Biol Educ
Gordon MT, Ratnayake RMMN, Rexford AM, Butcher RA.   +3 more
europepmc   +1 more source