Results 111 to 120 of about 37,330 (229)

Dynamic Combinatorial Mass Spectrometry Leads to Metallo-β-lactamase Inhibitors

, 2016
The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-β-lactamase enabled the rapid identification of an inhibitor with a Ki of
Patricia Lassaux (551037), Christopher J. Schofield (233097), Moreno Galleni (330047), Rebekka Hüting (2454799), Jean-Marie Frère (461305), Benoît M. R. Liénard (2454802)   +5 more
core   +1 more source

Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes

Microbial Cell Factories
β-lactam resistance is a significant global public health issue. Outbreaks of bacteria resistant to extended-spectrum β-lactams and carbapenems are serious health concerns that not only complicate medical care but also impact patient outcomes.
Lamiaa A. Al-Madboly, Mohamed A. Abd El-Salam, Jairo K. Bastos, Shaimaa Aboukhatwa, Rasha M. El-Morsi   +4 more
doaj   +1 more source

Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor

mBio
Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and structural integrity, and is a key antibiotic target. Its synthesis and turnover are carefully coordinated with other cellular processes and pathways.
Luke N. Yaeger, David Sychantha, Princeton Luong, Shahrokh Shekarriz, Océane Goncalves, Annamaria Dobrin, Michael R. Ranieri, Ryan P. Lamers, Hanjeong Harvey, George C. diCenzo, Michael Surette, Jean-Phiippe Côté, Jakob Magolan, Lori L. Burrows   +13 more
doaj   +1 more source

Experimental Evidence for a Metal‐Related Function of a Cyanobactin

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Cyanobactins such as patellamides are produced by cyanobacteria profusely and have been studied extensively, but almost exclusively for their cytotoxic properties. Discussed is unprecedented experimental evidence for a metal‐related biological function – likely CO2 transport from the ascidian to the cyanobacterial symbiont.
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Measuring the capacity of yeast for surface display of cell wall‐anchored protein isoforms by using β‐lactamase as a reporter enzyme

FEBS Open Bio
Yeast surface display is a promising biotechnological tool that uses genetically modified yeast cell wall proteins as anchors for enzymes of interest, thereby transforming yeast cell wall into a living catalytic material. Here, we present a comprehensive
Tea Martinić Cezar, Antonia Paić, Stefani Prekpalaj, Renata Teparić, Bojan Žunar, Igor Stuparević   +5 more
doaj   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Synthesis of β-lactamase inhibitors

, 1990
Twenty-two compounds of the type R¹C₆H₄CH₂(CO)NHCHR²(CO)OCHR³COOH, where R¹ = H or OH, R² = H or Me, and R³ = H, Me, Et, i-Pr, Ph, or CH₂COOH, have been synthesized for testing as β-lactamase inhibitors.
Gangwar, Sanjeev, 1961-
core  

Metal‐Dependent Effects and Crowding Robustness of Pseudomonas fluorescens Esterase I

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Pseudomonas fluorescens esterase I retains catalytic activity in metal‐rich and crowded environments, despite metal‐specific inhibitory effects. These findings highlight its robustness for biocatalytic applications in complex environments. Industrial biocatalysts are strongly influenced by their physicochemical environment, yet systematic studies on ...
Emmanouil Ntermanakis, Nikoleta Syngelaki, Alexandros Lyratzakis, Renia Fotiadou, Spyridoula Charova, Ioannis V. Pavlidis, Angeliki Giannouli   +6 more
wiley   +1 more source

Isothermal Titration Calorimetric Studies of Complexation Reactions

The objective of this work has been to study the binding of metal ions to complex ligands expressing two or more metal binding sites, in terms of the thermodynamics of the binding events, and to use this information to contribute to the understanding of ...
Motara, Hasina
core  

Small molecule Metallo-β-Lactamase inhibitors

, 2017
Several mechanisms have been discovered by which bacteria can acquire resistance against antibiotics. The most common and troubling resistance mechanism originates from the production of metallo-β-lactamases (4).
Gebreslasie, Kflom Yemane
core