Results 111 to 120 of about 38,167 (247)

Characterisation of a novel plasmid-mediated β-lactamase and its contribution to β-lactam resistance inPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1983
I.N. Simpson, S.J. Plested, Miroslava J. Budin-Jones, Jeanette Lees, R.W. Hedges, G.A. Jacoby   +5 more
openaire   +1 more source

N‐Sulfonyl Azalevoglucosan: A Versatile Platform for the Synthesis of Polysubstituted Piperidines

Chemistry – A European Journal, EarlyView.
Gain by strain: The synthesis of a levoglucosan analog, in which the pyranose oxygen has been replaced by a nitrogen, allows navigation on the piperidine ring to iteratively install functional groups at C1, C2, C3, C4, and C6 positions using simple experimental protocols with minimal protecting group manipulation.
Dylan Yorga, Jérôme Marrot, Ana Poveda, Nicolas Auberger, Jesús Jiménez‐Barbero, Jérôme Désiré, Yves Blériot   +6 more
wiley   +1 more source

Decreased affinity of a penicillin-binding protein for β-lactam antibiotics in a clinical isolate ofStaphylococcus aureusresistant to methicillin [PDF]

FEMS Microbiology Letters, 1981
Michael V. Hayes, Nigel A.C. Curtis, Anne W. Wyke, J. Barrie Ward   +3 more
openaire   +1 more source

Designing a Triplet 2‐Formylphenylnitrene With Fast Tunneling Reactivity

Chemistry – A European Journal, EarlyView.
A 3‐CF3 substituent accelerates tunneling in triplet 2‐formylphenylnitrene, making its reactivity in cryogenic matrices too fast for conventional IR spectroscopic detection. Bringing this chemistry to low‐temperature solutions allows suppression of intrinsic nitrene dimerization through faster cyclization, which even outcompetes the 1,4‐H shift ...
Sofia Braz, Cláudio M. Nunes, Simon Schlosser, Peter R. Schreiner, Rui Fausto   +4 more
wiley   +1 more source

单环β-内酰胺碱性条件下开环反应机理的理论研究

四川大学学报. 自然科学版, 1999
Five mono cycle β Lactams’ structures were optimized by semi empirical AM1 method of quantum chemistry.The ring opening reaction mechanism of mono cycle β Lactams in the presence of base were studied.The geometric configurations of reaction transition ...
廖显威, 李来才, 唐作华
doaj  

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Practical One‐Pot Synthesis of Cyclic Conjugated Amides From Ketones

European Journal of Organic Chemistry, EarlyView.
Cyclic conjugated amides from simple ketones: a one‐pot bromoform‐mediated homologation/amidation sequence provides direct access to 20 conjugated amides, including functionalized and linear examples, in up to 91% yield. Conjugated amides are valuable building blocks in organic synthesis; however, general access to cyclic conjugated amides remains ...
Maximilian Voigtländer, Johannes F. Teichert   +1 more
wiley   +1 more source