Results 121 to 130 of about 740,410 (298)

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams

, 2016
Solid-Supported Combinatorial Synthesis of Structurally Diverse β ...
Mark A. Gallop (2995320), Eric M. Gordon (2516743), Beatrice Ruhland (2995317), Ashok Bhandari (824447)   +3 more
core   +2 more sources

The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis.

PLoS Pathogens, 2019
β-lactam antibiotics interfere with cross-linking of the bacterial cell wall, but the killing mechanism of this important class of antibiotics is not fully understood.
Camilla Jensen, Kristoffer T Bæk, Clement Gallay, Ida Thalsø-Madsen, Lijuan Xu, Ambre Jousselin, Fernando Ruiz Torrubia, Wilhelm Paulander, Ana R Pereira, Jan-Willem Veening, Mariana G Pinho, Dorte Frees   +11 more
doaj   +1 more source

Nova metodologia de bromação dos adutos de morita-baylishillman E sua utilização como intermediários sintéticos na Preparação de heterociclos [PDF]

, 2008
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Neste trabalho será apresentada uma nova metodologia sintética simples e eficiente para a preparação de (Z)-2-(bromometil)-2-alcenoatos a
FERREIRA, Misael
core  

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Re-evaluation of the significance of penicillin binding protein 3 in the susceptibility of Listeria monocytogenes to β-lactam antibiotics

BMC Microbiology, 2012
Background Penicillin binding protein 3 (PBP3) of L. monocytogenes has long been thought of as the primary lethal target for β-lactam antibiotics due to the excellent correlation between the MICs of different β-lactams and their affinity for this protein.
Krawczyk-Balska Agata, Popowska Magdalena, Markiewicz Zdzislaw   +2 more
doaj   +1 more source

Regio- and Stereocontrolled Metal-Mediated Carbonyl Propargylation or Allenylation of Enantiomerically Pure Azetidine-2,3-diones:  Synthesis of Highly Functionalized 3-Substituted 3-Hydroxy-β-lactams

, 2016
Regio- and stereocontrolled metal-mediated Barbier-type reactions of azetidine-2,3-diones with differently substituted propargyl bromides offer an efficient asymmetric entry to densely functionalized 3-propargyl- (or allenyl-) substituted 3-hydroxy-β ...
Benito Alcaide (1554658), Cristina Aragoncillo (1771678), Pedro Almendros (1554667)   +2 more
core   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Interaction of β-lactam antibiotics with penicillin-binding proteins fromPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1982
Alfredo Rodriguez-Tebár, Fernando Rojo, Juan C. Montilla, David Vázquez   +3 more
openaire   +1 more source

Excited-State Copper-Catalyzed [4 + 1] Annulation Reaction Enables Modular Synthesis of α,β-Unsaturated-γ-Lactams

Synthesis of α,β-unsaturated-γ-lactams continue to attract attention due to the importance of this structural motif in organic chemistry. Herein, we report the development of a visible-light-induced excited-state copper-catalyzed [4 + 1] annulation ...
Satavisha Sarkar (7511555), Upasana Mukherjee (4924993), Christopher J. Johnson (221463), Nicoline C. Frederiks (14051573), Arghya Banerjee (1479340), Jagrut A. Shah (14051570), Ming-Yu Ngai (1530934)   +6 more
core   +1 more source