Results 61 to 70 of about 893,542 (154)

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
Smith, Edward M., Wilke, Russell A., Sidjanin, Duska J., McCarty, Catherine A., Patchett, Richard   +4 more
core   +1 more source

β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway

Antioxidants
Oxidative stress is a significant factor in the death of granulosa cells (GCs), leading to follicular atresia and consequently limiting the number of dominant follicles that can mature and ovulate within each follicular wave.
Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang   +8 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Fermentation Process and Functional Properties of β-Nicotinamide Mononucleotide-enriched Fruit-Vegetable Jiaosu

Shipin gongye ke-ji
In order to study the β-nicotinamide mononucleotide-enriched fruit-vegetable Jiaosu and evaluate its bioactivity, cucumber powder, broccoli powder, banana powder and apple powder were used as substrates, and the process parameters were optimized by multi-
Tao JI, Xuanyi CHEN, Ziyang CHENG, Yonghai RUAN, Senhe QIAN, Zhou WANG   +5 more
doaj   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells [PDF]

, 2016
NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside
Boutant, Marie, Migaud, Marie E., Ratajczak, Joanna, Ras, Rosa, Trammell, Samuel A. J., Auwerx, Johan, Trammell, Samuel A.J., Kulkarni, Sameer S., Yanes, Oscar, Joffraud, Magali, Trammell, Samuel A J, Rodrigues, Marcelo, Redpath, Philip, Canela, Nuria, Brenner, Charles, Cantó, Carles   +15 more
core   +3 more sources

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Nicotinamide Mononucleotide Restores Pancreatic β-Cell Function in Type 2 Diabetes through SIRT6-HIF-1α-Mediated Mitochondrial Stress Adaptation and Glycolytic Reprogramming

Type 2 diabetes mellitus (T2DM) is characterized by progressive pancreatic β-cell dysfunction, in which mitochondrial impairment represents a central pathogenic event.
Yajing Chen, Gang Qi, Chao Gu, Qiuhui Wang, Mei Wang, Chunhua Ma, Qian Zhou, Rui Wang   +7 more
core   +1 more source

β-Nicotinamide mononucleotide improves chilled ram sperm quality in vitro by reducing oxidative stress damage [PDF]

Animal Bioscience
Objective The present study aimed to investigate the effect of β-nicotinamide mononucleotide (NMN) supplementation on ram sperm quality during storage at 4°C in vitro. Methods Tris-citric acid-glucose solution containing different doses of NMN (0, 30, 60,
Zhendong Zhu, Haolong Zhao, Qitai Yang, Yajing Li, Ruyuan Wang, Adedeji Olufemi Adetunji, Lingjiang Min   +6 more
doaj   +1 more source

Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion [PDF]

, 2015
BAM is a conserved molecular machine, the central component of which is BamA. Orthologues of BamA are found in all Gram-negative bacteria, chloroplasts and mitochondria where it is required for the folding and insertion of β-barrel containing integral ...
Jeeves, Mark, Mason, Jessica L, Knowles, Timothy J., Rossiter, Amanda E, Rossiter, Amanda E.; id_orcid, Browning, Douglas F., Bavro, Vassiliy N., Henderson, Ian R., Cunningham, Adam F., Overduin, Michael, Sevastsyanovich, Yanina R., Rossiter, Amanda E., Donald, James W., Browning, Douglas F, Wells, Timothy J, Henderson, Ian R, Knowles, Timothy J.; id_orcid, Wells, Timothy J., Palmer, Tracy, Knowles, Timothy J, Sevastsyanovich, Yanina R, Cunningham, Adam F, Mason, Jessica L., Bavro, Vassiliy N, Donald, James W   +24 more
core   +1 more source