Results 71 to 80 of about 893,542 (154)

Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

, 2021
BACKGROUND: The activation of NAD(+)-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases.
Yasuda, Itaru, Hirobumi Tokuyama, Shu Wakino, Ei Kusahana, Takashi Ono, Hiroshi Itoh, Kusahana, Ei, Takeshi Kanda, Muraoka, Hirokazu, Tokuyama, Hirobumi, Kanda, Takeshi, Yusuke Sakamaki, Itoh, Hiroshi, Takahisa Kawaguchi, Sakamaki, Yusuke, Wakino, Shu, Ono, Takashi, Kazuhiro Hasegawa, Hirokazu Muraoka, Kawaguchi, Takahisa, Itaru Yasuda, Hasegawa, Kazuhiro   +21 more
core   +1 more source

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells [PDF]

, 2017
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Migaud, Marie E., Lucy A. Oakey, Rachel S. Fletcher, Carles Canto, Brenner, C, Migaud, ME, Oakey, Lucy A, Gabriella Da Silva Xavier, Joanna Ratajczak, Craig L. Doig, Philp, A, Lavery, Gareth G., Canto, Carles, Da Silva Xavier, Gabriella; id_orcid, Canto, C, Garten, Antje, Oakey, Lucy A., Elhassan, Yasir S., Lavery, GG, Yasir S. Elhassan, Elhassan, Yasir S; id_orcid, Elhassan, YS, Ratajczak, Joanna, Callingham, Rebecca, Fletcher, RS, Redpath, P, Antje Garten, Garten, A, Xavier, Gabriella Da Silva, Da Silva Xavier, G, Oakey, LA, Doig, Craig L., Fletcher, Rachel S., Andrew Philp, Gareth G. Lavery, Migaud, Marie E, Brenner, Charles, Charles Brenner, Marie E. Migaud, Ratajczak, J, Callingham, R, Rebecca Callingham, Philp, Andrew, Doig, CL, Doig, Craig L, Redpath, Philip, Lavery, Gareth G, Philip Redpath, Fletcher, Rachel S   +48 more
core   +1 more source

Implications of altered NAD metabolism in metabolic disorders

Journal of Biomedical Science, 2019
Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation.
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe, Takashi Nakagawa   +3 more
doaj   +1 more source

Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes

Current Issues in Molecular Biology
Skin aging is primarily driven by oxidative stress, mitochondrial dysfunction, and cell cycle dysregulation. This study investigated the anti-senescence effects of fermented porcine placenta (FPP) and its dipeptides, leucine–glycine (LG) and proline ...
Yea Jung Choi, Minseo Kang, Mu Hyun Jin, Jongbae Kim, Won Kyung Lee, Seok-Seon Roh, Ki Sung Kang, Gwi Seo Hwang, Sangki Park, Sullim Lee   +9 more
doaj   +1 more source

A genome wide association scan for (1,3;1,4)-β-glucan content in the grain of contemporary 2-row Spring and Winter barleys [PDF]

, 2014
Background: (1,3;1,4)-β-Glucan is an important component of the cell walls of barley grain as it affects processability during the production of alcoholic beverages and has significant human health benefits when consumed aboverecommended threshold levels.
Russell, J., Oakey, H., Neil Shirley, Jennifer M Washington, Schreiber, Miriam, Booth, A., Joanne Russell, Russell, Joanne, Houston, Kelly, Houston, K., Fincher, G., Booth, Allan, Helena Oakey, Schreiber, M., Shirley, Neil, Shirley, N., Washington, Jennifer M., Rachel A Burton, Halpin, C., Burton, Rachel A., Waugh, R., Miriam Schreiber, Halpin, Claire, Robbie Waugh, Oakey, Helena, Fincher, Geoffrey B., Washington, J., Kelly Houston, Geoffrey B Fincher, Allan Booth, Waugh, Robbie; id_orcid, Burton, R., Claire Halpin   +32 more
core   +1 more source

Metabolomic analysis reveals the positive effects of Rhizopus oryzae fermentation on the nutritional and functional constituents of adlay millet seeds

Scientific Reports
Adlay millet seeds are well known for excellent health benefits. However, using fungal fermentation to improve their nutritional and functional constituents and the underlying mechanisms has not been thoroughly investigated.
Caihua Liu, Jian Wei, Mingde Shi, Xunwen Huang, Zisong Wang, Qiuliu Liu, Tao Lang, Zhengjie Zhu   +7 more
doaj   +1 more source

Dietary Nicotinamide Mononucleotide, a Key NAD⁺ Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in db/db Mice

Metabolites
Background/Objectives: Supplementation with nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD+) intermediate, exerts anti-aging, anti-obesity, and anti-diabetic effects in animal experiments.
Bungo Shirouchi, Sarasa Mitsuta, Mina Higuchi, Mai Okumura, Kazunari Tanaka   +4 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science
The brain plays a central role in aging and longevity in diverse model organisms. Morphological and functional alteration in the aging brain elicits age‐associated neuronal dysfunctions. However, the primary mechanism deteriorating the brain functions to
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
doaj   +1 more source

The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications

Frontiers in Pharmacology
β-nicotinamide mononucleotide (NMN) is a naturally occurring biologically active nucleotide widely present in organisms and an inherent substance in the human body.
Bin Yu, Bin Yu, Xiaotong Jing, Lina Jia, Maoru Wang, Liying Liu, Songyuge Ping, Yu Wang, Min Yang   +8 more
doaj   +1 more source