Results 91 to 100 of about 8,460 (141)

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

The Effects of BACE and Its Targets on Age-related Seizures in \u3cem\u3eDrosophila\u3c/em\u3e [PDF]

, 2015
The presence of Beta-Amyloid (Aβ) containing plaques in the brain is one of the histological hallmarks of Alzheimer’s Disease. β-secretase (BACE) is the enzyme responsible for producing this Aβ cleavage product and has also been shown to affect ...
Chiu, Trey Anthony, Gibbon, Dana
core   +1 more source

Phosphate‐ and pH‐dependent self‐assembly of recombinant spider silk proteins

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The process of molecular self‐assembly is an omnipresent mechanism in nature to generate a variety of efficient and functional hierarchical architectures, and inspires tailored material design and development. Thereby, self‐assembly is based on a controlled interplay and association of monomers into highly ordered structures triggered by ...
Vanessa T. Trossmann, Veronika Hovanová, Tim Schiller, Martin Humenik, Erik Sedlák, Thomas R. Scheibel   +5 more
wiley   +1 more source

Contrasting effects of acute and long-term corticosterone treatment on amyloid-β, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation

Journal of Integrative Neuroscience, 2019
Regulation of neuroinflammation is critical to control the detrimental impact of chronic stress in the central nervous system. Neuroinflammation occurs in response to chronic stress, leading to enhanced neuronal damage in the brain.
Yangyang Hou, Shaolei Luo, Yaping Zhang, Yue Jia, Haoran Li, Chunjie Xiao, Hongkun Bao, Jing Du   +7 more
doaj   +1 more source

Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

PLoS ONE, 2011
BackgroundAlzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase.
Hao Cui, Amos C Hung, David W Klaver, Toshiharu Suzuki, Craig Freeman, Christian Narkowicz, Glenn A Jacobson, David H Small   +7 more
doaj   +1 more source

Herpes simplex virus interferes with amyloid precursor protein processing [PDF]

, 2005
Background The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV1) in brain and carriage of the
Dobson, C.B., Itzhaki, R.F., Parkin, E.T., Shipley, S.J.   +3 more
core   +4 more sources

EN2 Regulates Pancreatic Cancer Initiation, Progression, and Epithelial‐Mesenchymal Transition Through the Notch Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT The incidence and mortality of pancreatic cancer are steadily increasing worldwide, and the disease is projected to become the second leading cause of cancer‐related deaths by 2030. Pancreatic tumorigenesis is driven by multiple genetic alterations, underscoring the need to elucidate the molecular mechanisms underlying pancreatic ...
Wei Yu, Raj K. Varma, Yiming Ma, Varun Chandra Boinpelly, Areej Khatri, Emma Gombos, Rakesh K. Srivastava, Sharmila Shankar   +7 more
wiley   +1 more source

Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila.

PLoS ONE, 2015
The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD). APP can undergo two exclusive proteolytic pathways: cleavage by the α-secretase initiates the non-amyloidogenic pathway while cleavage by the β-secretase initiates the ...
Isabelle Bourdet, Aurélie Lampin-Saint-Amaux, Thomas Preat, Valérie Goguel   +3 more
doaj   +1 more source

Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein [PDF]

, 2011
In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ.
Andersen, Anthony J. Turner, Benjannet, Bennett, Bennett, Calella, Capell, Carolyn D. Jackson, Cole, Cole, Creemers, Debbie Brown, Fukumoto, Gimbel, Haass, Haugabook, Heledd H. Griffiths, Herbert Baybutt, Hooper, Huse, Isobel J. Whitehouse, Jean C. Manson, Katherine A.B. Kellett, Kawarabayashi, Kayed, Kayed, Li, Manson, Morrissette, Mucke, Mullan, Murrell, Nigel M. Hooper, Parkin, Pedro Piccardo, Piccardo, Schwarze-Eicker, Selkoe, Spoelgen, Sun, Thinakaran, Vardy, Vassar, Vassar, Walmsley, Walsh, Whitehouse, Yamakawa, Yan, Zhao   +49 more
core   +1 more source