Chemical Diversity of β-Secretase Inhibitors From Natural Resources
Natural Product Communications, 2019 Reports on β-secretase inhibitors of natural origin are listed in order to reveal their chemical diversity. Various types of compounds were found to inhibit β-secretase, and natural resources included a wide spectrum of biological species.
Kazuya Murata
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The Role of SNX8 in Alzheimer’s Disease [PDF]
, 2014 阿尔茨海默病（Alzheimer’sdisease，AD）一个重要的病理学特征是在神经细胞外形成主要由β淀粉样蛋白（βamyloid，Aβ）组成的淀粉样斑（amyloidplaques）。大脑内具有神经毒性的Aβ的累积在AD的发病过程中处于中心地位。β淀粉样蛋白前体蛋白（βamyloidprecursorprotein，APP）依次经过β分泌酶和γ分泌酶切割后可以产生Aβ和APP的胞内结构域（APPintracellulardomain，AICD ...
谢勇壮
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Physical activity and beta-amyloid pathology in Alzheimer's disease [PDF]
, 2017 Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative treatment has not been established for AD yet and due to heavy financial and psychological costs of patients’ care, special attention has been paid to preventive ...
Baghaiee, Behrouz +4 more
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Frontiers in Chemistryβ-secretase 1, one of the most important proteins, is an aspartate protease. This membrane-associated protein is used for treating Alzheimer’s disease (AD).
Xu Han, Kaibo Guo
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Strategies to deliver peptide drugs to the brain [PDF]
, 2014 Lalatsa, Katerina +2 more
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Gram-Scale Synthesis of a β‑Secretase 1 (BACE 1) Inhibitor
ACS Omega, 2017 Brett D. Allison, Neelakandha S. Mani
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3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish” [PDF]
, 2016 core +1 more source
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice [PDF]
, 2015 core +1 more source
Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer’s disease cybrid cells [PDF]
, 2015 core +1 more source
The 37kDa/67kDa Laminin Receptor LRP/LR as a molecular target in neurodegenerative diseases [PDF]
, 2009 Pflanz, Heike
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