Results 101 to 110 of about 8,460 (141)
Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains
Neurobiology of Disease, 2002 Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be isolated from cultured cells and brain by several different fractionation procedures that are ...
Suzanne Wahrle +8 more
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The effect of overexpressing SNX8 on the phenotype of Alzheimer’s mice [PDF]
, 2015 阿尔茨海默病（Alzheimerdisease，AD）是最为常见的神经退行性疾病。神经元胞外Aβ（Amyloidβ，Aβ）聚集形成的淀粉样斑是AD的一个重要的病理特征，而Aβ是由淀粉样前体蛋白APP（AmyloidPrecursorProtein，APP）经β-分泌酶（β-secretase）和γ-分泌酶（γ-secretase）依次切割后生成的（即淀粉样蛋白途径），而APP的另一条剪切途径是α-分泌酶（α-secretase）和γ-分泌酶依次对其进行剪切，释放有神经保护作用的sAPPα ...
纪成香
core
Human Umbilical Cord Blood Serum–derived α-Secretase
Cell Transplantation, 2018 Alzheimer’s disease (AD) is an age-related disorder that affects cognition. Our previous studies showed that the neuroprotective fragment of amyloid procurer protein (APP) metabolite, soluble APPα (sAPPα), interferes with β-site APP-cleaving enzyme 1 ...
Ahsan Habib +9 more
doaj +1 more source
ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.
PLoS ONE, 2016 ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has ...
Osamu Sano +9 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2019 Processing of amyloid beta precursor protein (APP) into amyloid-beta peptide (Aβ) by β-secretase and γ-secretase complex is at the heart of the pathogenesis of Alzheimer’s disease (AD).
Laura García-González +3 more
doaj +1 more source
Molecules, 2009 Selective lowering of amyloid-β levels with small-molecule γ-secretase inhibitors is a promising therapeutic approach for Alzheimer’s disease. In this work, we developed a high throughput assay for screening of γ-secretase inhibitors with endogenous γ ...
Lie-Feng Wang, Xin Xie, Ru Zhang
doaj +1 more source
Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]
, 2010 Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
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Implications of cholesterol and cholesterol-lowering therapy in Alzheimer s disease [PDF]
, 2007 BACKGROUND: Alzheimer s disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia.
Famer, Daniel
core
Scientific ReportsAlzheimer’s disease (AD) is a neurological disorder characterized by memory loss, language difficulties, and the loss of planning and coordination skills.
E. N. Agbo +4 more
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Secretase promotes AD progression: simultaneously cleave Notch and APP
Frontiers in Aging NeuroscienceAlzheimer’s disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II.
Ke-Fan Yang +7 more
doaj +1 more source