Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models
VIEW, Volume 7, Issue 1, February 2026.Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
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Aging Cell, Volume 25, Issue 2, February 2026.Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang +11 more
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Influence of membrane lipid composition on the structure and activity of γ-secretase
, 2018 Rodrigo Aguayo‐Ortiz +2 more
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Targeted Nanodelivery of WGX50 and Curcumin via Gold Nanoparticles for Alzheimer's Therapy
Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder, posing a global health challenge. It affects millions of people, causing cognitive decline and a heavy burden on healthcare systems. Neuroinflammation is a key pathological feature of AD, often associated with the dysregulation of microRNAs such as hsa‐miR‐146a‐5p. WGX50 (N‐[
Madeeha Shahzad Lodhi +5 more
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γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
, 2022 Lucas Restrepo +8 more
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γ‐Secretase inhibitor alleviates lipopolysaccharide‐induced myocardial injury through regulating
, 2023 Jingyun Fang, Huan Guan
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Molecular Dynamics Activation of γ-Secretase for Cleavage of the Notch1 Substrate. [PDF]
ACS Chem Neurosci, 2023 Do HN, Malvankar SR, Wolfe MS, Miao Y.
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Journal of Neurochemistry, Volume 170, Issue 2, February 2026.The interplay between the cholesterol metabolism and assembly of Aβ42 (Amyloid beta‐42) peptide in pathological aggregates is considered one of the major molecular mechanisms in the development of Alzheimer's disease (AD). Our combined studies revealed that Aβ42 was capable of removing cholesterol from the membrane at physiologically relevant low ...
Rishiram Baral +2 more
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A γ-Secretase Inhibitor Attenuates Cell Cycle Progression and Invasion in Human Oral Squamous Cell Carcinoma: An In Vitro Study [PDF]
, 2022 Sarai Pongjantarasatian +8 more
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USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies
Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge +5 more
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