Beilstein Journal of Organic Chemistry, 2013 The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket ...
Thomas A. Munro +4 more
doaj +1 more source
Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats [PDF]
, 2015 Xuan Zhou +5 more
openalex +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. [PDF]
J Chem Inf Model, 2023 Salas-Estrada L +9 more
europepmc +1 more source
Electroacupuncture as a treatment for suspected trigeminal nerve‐mediated head‐shaking in 42 horses
Equine Veterinary Education, Volume 37, Issue 12, Page 647-653, December 2025.Summary Background Electroacupuncture (EA) has been used successfully as a treatment for trigeminal nerve‐mediated head‐shaking (TMHS) in a small case series, but results from a larger number of cases are lacking. Objectives To retrospectively investigate the effectiveness of EA as a treatment for horses with TMHS.
B. Dunkel +5 more
wiley +1 more source
Opioids in cancer: The κ‑opioid receptor (Review). [PDF]
Mol Med Rep, 2022 Zhou Q +5 more
europepmc +1 more source
Journal of the American Geriatrics Society, Volume 73, Issue 12, Page 3778-3788, December 2025.Association between herpes zoster and risk of incident fragility fractures in US veterans: a matched cohort study. ABSTRACT Background Herpes zoster (HZ) and fragility fractures typically affect older adults and present major burdens to healthcare systems.
Calif A. A. Yousuf +4 more
wiley +1 more source
The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies
Obesity Reviews, Volume 26, Issue 12, December 2025.ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin +6 more
wiley +1 more source
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. [PDF]
Protein Cell, 2023 Chen Y, Chen B, Wu T, Zhou F, Xu F.
europepmc +1 more source
κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO‐1 Pathway and Regulating Ca2+‐SERCA2a [PDF]
, 2021 Tengfei Wu +5 more
openalex +1 more source