Results 91 to 100 of about 62,533 (281)
Czech Journal of Animal Science, 2017 Despite progress in studying the role of opioids in reward, the effect of opioid receptors on feeding behaviour in ad libitum fed meat-type chicken offered different diet types is still unclear.
Shoresh Arva +5 more
doaj +1 more source
In vivo trafficking of endogenous opioid receptors [PDF]
, 2008 Studies on trafficking of endogenous opioid receptors in vivo are subject of the present review. In many of the in vivo studies, the use of semi-quantitative immuno-electron microscopy is the approach of choice.
Liu-Chen, Lee-Yuan +2 more
core +2 more sources
Suicide Deaths in People With Bipolar Disorder: Characteristics and Treatments at Time of Death
Bipolar Disorders, EarlyView.ABSTRACT Objectives This study aimed to compare suicide deaths in those with or without bipolar disorder (BD), taking into particular consideration the degree to which treatment at the time of death, according to toxicology data, reflects evidence‐based pharmacotherapy.
Ayal Schaffer +7 more
wiley +1 more source
Novel κ-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation
Acta Pharmacologica Sinica, 2015 Aim:To characterize the pharmacological profiles of a novel κ-opioid receptor agonist MB-1C-OH.Methods:[3H]diprenorphine binding and [35S]GTPγS binding assays were performed to determine the agonistic properties of MB-1C-OH. Hot plate, tail flick, acetic
Le-sha Zhang +11 more
semanticscholar +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Hyaluronic acid induces activation of the κ-opioid receptor.
PLoS ONE, 2013 IntroductionNociceptive pain is one of the most common types of pain that originates from an injury involving nociceptors. Approximately 60% of the knee joint innervations are classified as nociceptive.
Barbara Zavan +7 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice. [PDF]
PLoS ONE, 2013 Neuropathic pain is a debilitating chronic disease often resulting from damage to peripheral nerves. Activation of opioid receptors on peripheral sensory neurons can attenuate pain without central nervous system side effects. Here we aimed to analyze the
Yvonne Schmidt +2 more
doaj +1 more source
Effect of intrauterine morphine sulfate exposure on cerebellar histomorphological changes in neonatal mice [PDF]
, 2011 Neurotoxic effects of morphine sulfate in adult cerebellar cortex and neonatal cerebral cortex have been studied in animal models. This study was done to determine the neurotoxic effects of prenatal morphine exposure on the histo morphological changes of
Ghafari, S. +2 more
core
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source