Results 91 to 100 of about 9,643 (193)

Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. [PDF]

J Med Chem, 2023
Muratspahić E, White AM, Ciotu CI, Hochrainer N, Tomašević N, Koehbach J, Lewis RJ, Spetea M, Fischer MJM, Craik DJ, Gruber CW.   +10 more
europepmc   +1 more source

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

Nano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini, Gillian D. Mahumane, Pradeep Kumar, Yahya E. Choonara   +3 more
wiley   +1 more source

Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity

Beilstein Journal of Organic Chemistry, 2013
The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket ...
Thomas A. Munro, Wei Xu, Douglas M. Ho, Lee-Yuan Liu-Chen, Bruce M. Cohen   +4 more
doaj   +1 more source

Pharmacotherapeutic Controversies During Temperature Control After Out‐of‐Hospital Cardiac Arrest: A Semi‐Structured Literature Review

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Post‐resuscitation cardiac arrest care begins at the time of hospital admission and focuses on preventing the sequelae of ischemia–reperfusion injury, including secondary brain damage and post‐cardiac arrest syndrome. Clinical practice guidelines on post‐resuscitation cardiac arrest care from international medical organizations outline ...
Christy Cecil Forehand, Scott Thomas Benken, Melanie Madorsky, Adham Mohamed, Jerika V. Nguyễn, Deepali Dixit, Jolie Gallagher, William Anthony Hawkins, Mojdeh Saba Heavner, Emory Johnson, Lauren Lozano, Melanie Sisco, Angela A. Slampak‐Cindric, Susan Elizabeth Smith, Katherine Spezzano, Bayard Angel Taylor II, Nathaniel Brett Wayne, David John Gagnon   +17 more
wiley   +1 more source

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. [PDF]

J Chem Inf Model, 2023
Salas-Estrada L, Provasi D, Qiu X, Kaniskan HÜ, Huang XP, DiBerto JF, Lamim Ribeiro JM, Jin J, Roth BL, Filizola M.   +9 more
europepmc   +1 more source

Effectiveness of Psychosocial Interventions for Adults With Substance Use Disorder That Have a Co‐Occurring Common Mental Health Disorder: An Umbrella Review

Drug and Alcohol Review, Volume 45, Issue 1, January 2026.
ABSTRACT Issues People with substance use disorders can have co‐occurring mental disorders. Approach An umbrella review was conducted to identify evidence of the effectiveness of psychosocial interventions for adults (aged 18+) with substance use disorders and co‐occurring common mental health disorders.
Emma L. Simpson, Munira Essat, Ruth Wong, Sarah Stacey, Edward Day   +4 more
wiley   +1 more source

Opioids in cancer: The κ‑opioid receptor (Review). [PDF]

Mol Med Rep, 2022
Zhou Q, Zhang Z, Long S, Li W, Wang B, Liang N.   +5 more
europepmc   +1 more source

Debittering and Masking Soy Peptides for Oral Consumption and Immune‐Boosting Function

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Soy peptides (SPs) have been extensively studied with an emphasis on their immune‐boosting effects and production‐associated bitterness. This associated bitterness affects SPs’ oral consumption despite their bioactivities. In this review, the immune‐boosting functions, factors affecting bitterness, and consumers’ perceptions of SPs are explored ...
Wei Li, Chaoling Wen, Opeyemi Joshua Olatunji, Chi Ching Lee, Tolulope Joshua Ashaolu, Anupama Bose   +5 more
wiley   +1 more source

Progress in Research on Alleviating the Symptoms Associated With Advanced Cancer Using Traditional Chinese Medicine

Pain Research and Management, Volume 2026, Issue 1, 2026.
Advanced cancer continues to pose a substantial global challenge, with complex symptom burdens and limited therapeutic options. Traditional Chinese Medicine (TCM), grounded in holistic theory and the principles of syndrome differentiation, employs interventions such as herbal medicine, acupuncture, moxibustion, and acupoint‐based therapies to address ...
Chunmeng Jiao, Ting Zhang, Yachen Yang, Ruofan Zhang, Wenbo Liu, Yanqing Wang, Lei Huang   +6 more
wiley   +1 more source

Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. [PDF]

Protein Cell, 2023
Chen Y, Chen B, Wu T, Zhou F, Xu F.
europepmc   +1 more source