Results 121 to 130 of about 62,533 (281)

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Frontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony, Bincy Baby, Ranjit Vijayan, Ranjit Vijayan, Ranjit Vijayan   +4 more
doaj   +1 more source

Potential use of early alterations in μ and δ opioid receptors as a predictive index for delayed brain ischemic damage

Neurobiology of Disease, 2003
We previously reported differential alterations of the μ, δ, and κ opioid receptors following permanent middle cerebral artery occlusion. The present work studied the evolution of opioid receptor types following transient focal cerebral ischemia (tMCAO),
Hervé Boutin, Philippe Jauzac, Eric T. MacKenzie, François Dauphin   +3 more
doaj   +1 more source

Inhibition of GABAergic Neurotransmission by HIV-1 Tat and Opioid Treatment in the Striatum Involves μ-Opioid Receptors [PDF]

, 2016
Due to combined antiretroviral therapy (cART), human immunodeficiency virus type 1 (HIV-1) is considered a chronic disease with high prevalence of mild forms of neurocognitive impairments, also referred to as HIV-associated neurocognitive disorders (HAND)
Changqing Xu, Sylvia Fitting
core   +3 more sources

Fatal drug overdoses in healthcare workers: A thematic framework analysis of coroner reports

Addiction, Volume 120, Issue 11, Page 2270-2281, November 2025.
Abstract Background and aims Healthcare workers face specific vulnerabilities for drug overdose due to their unique access to medications, clinical knowledge and work‐related stress. This study aimed to understand the characteristics of fatal overdoses in healthcare workers with a view to providing guidance for preventative strategies.
Thikra Algahtani, Siobhan Gee, Aminah Shah, Bryn D. Williams, Hayley C. Gorton, Sarah Welch, Caroline S. Copeland   +6 more
wiley   +1 more source

Indolo[2,3-a]quinolizidines and derivatives: Bioactivity and asymmetric Synthesis [PDF]

, 2016
Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia and in the life science industries due to their broad bioactivity profile.
Espadinha, Margarida, Pérez Bosch, Maria, Santos, Maria M. M.   +2 more
core   +1 more source

Acupuncture for induction of labor in uncomplicated term pregnancies and the role of the acupoint selection: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 11, Page 2038-2053, November 2025.
This systematic review and meta‐analysis evaluated the effects of acupuncture for labor induction after 37 weeks of gestation, with a focus on different acupoint selection strategies. No significant improvements were found in labor progression or birth outcomes compared to sham acupuncture or usual care; the certainty of evidence ranged from very low ...
An Chen, Jiawen Zhang, Du Gao, Ying Xu, Shijia Jin, Tianyi Zhou, Fan Qu, Ganesh Acharya   +7 more
wiley   +1 more source

Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist

British Journal of Pharmacology, 2014
The opioid receptor family comprises four structurally homologous but functionally distinct sub‐groups, the μ (MOP), δ (DOP), κ (KOP) and nociceptin (NOP) receptors.
A. M. Taylor, A. M. Taylor, K. W. Roberts, A. Pradhan, A. Pradhan, H. Akbari, W. Walwyn, K. Lutfy, F. Carroll, C. M. Cahill, C. J. Evans   +10 more
semanticscholar   +1 more source

A procedure to identify persistent and effort‐independent individual differences in preference for heroin over rewarding social interaction

British Journal of Pharmacology, Volume 182, Issue 22, Page 5596-5610, November 2025.
Background and Purpose In some individuals, opioid use leads to decreased interest in socially relevant rewards. Recent studies showed that after extended‐access heroin self‐administration, rats strongly prefer social interaction over single unit‐dose heroin infusions.
Ginevra D'Ottavio, Alana Sullivan, Sara Pezza, Maria Chiara Ruano, Jacopo Modoni, Ingrid Reverte, Claudia Marchetti, Soami F. Zenoni, Marco Venniro, Michele S. Milella, Fernando Boix, Yavin Shaham, Daniele Caprioli   +12 more
wiley   +1 more source

Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors [PDF]

, 2017
Cocaine addiction is a widespread psychiatric condition still waiting for approved efficacious medications. Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to
Cannella, Nazzareno, Ciccocioppo, Roberto, Deng, Yulin, Shen, Qianwei   +3 more
core   +1 more source

Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon

Journal of Internal Medicine, Volume 298, Issue 5, Page 392-423, November 2025.
Abstract Alcohol and other substance use disorders (ASUDs) are prevalent and major contributors to global morbidity and mortality. Their impact extends beyond the individual, imposing significant burdens on families, communities, healthcare systems, and society at large.
Anna Loften, Mehdi Farokhnia, Leandro F. Vendruscolo, Lorenzo Leggio   +3 more
wiley   +1 more source