Results 121 to 130 of about 18,176 (269)

The aetiology of social deficits within mental health disorders:The role of the immune system and endogenous opioids [PDF]

, 2019
The American National Institute for Mental Health (NIMH) has put out a set of research goals that include a long-term plan to identify more reliable endogenous explanations for a wide variety of mental health disorders (Insel, 2013). In response to this,
Adler, Akil, Allsopp, Almatroudi, Alves, American Psychiatric Association, Ashok, Ashwood, Ashwood, Bagnato, Bakermans-Kranenburg, Bakermans-Kranenburg, Barr, Barton, Benabid, Benarroch, Benjamin, Bianco, Bjørklund, Blanchard, Bouvard, Browne, Browne, Burkett, Burkett, Bär, Börner, Börner, Cahill, Campbell, Carrizo, Chong, Cohen, Corcoran, Cosentino, Dantzer, Dunbar, Dunbar, Eichaar, Elias, Fried, Fried, Gallagher, Garcia-Rizo, Garduño-Gutiérrez, Gassen, Gesundheit, Gillespie, Glaser, Godoy, Griffiths, Hipólito, Hsu, Hwang, Inagaki, Insel, Insel, Jiménez, Johnson, Jokela, Kahl, Kalin, Kautzky, Kelm-Nelson, Kessing, Keverne, Kobayashi, Kolmen, Kucerova, Lamers, Lamers, Lasalvia, Lawson, Le Foll, Lee, Li, Li, Li, Li, Li, Liang, Lépine, Løseth, Ma, Machin, Manabe, Marazziti, Margolis, Martel, Medzhitov, Meltzer, Meyer, Miller, Moieni, Morris, Muneer, Murphy, Müller, Nave, Nelson, Nemeroff, Neugebauer, Nguyen, NHS, Nikulina, Nikulina, Nummenmaa, Oertel, Onore, Panksepp, Panksepp, Panksepp, Panksepp, Panksepp, Pariante, Pariante, Pariante, Parra-Gámez, Pellissier, Penninx, Plein, Polter, Prata, Preskorn, Ragen, Raison, Resendez, Rosenblat, Rossignol, Roy, Roy, Rudolf, Sacerdote, Sakson-Obada, Sandman, Sarkar, Scherrer, Scifo, Shumake, Slavich, Stein, Stigler, Stubbs, Suvisaari, Suzuki, Szűcs, Tanaka, Tarr, Tarr, Thompson, Upthegrove, Urban-Kowalczyk, van Os, Vanderschuren, Vogelzangs, Wang, Wei, Wimberley, Witt, Wybran, Zhang, Zheng, Zubieta, Zubieta, Zubieta, Łojko   +165 more
core   +1 more source

Steroid Receptors and Vertebrate Evolution [PDF]

arXiv, 2019
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv  

Add‐On Dextromethorphan Improves the Effects of Pirfenidone in Bleomycin‐Treated Mice and Patients With Pulmonary Fibrosis

Respirology, EarlyView.
ABSTRACT Background and Objective Idiopathic pulmonary fibrosis is a progressive interstitial lung disease characterised by excessive activation of myofibroblasts. However, currently available antifibrotic drugs exhibit limited efficacy. The dysregulation of redox processes plays a significant role in the pathogenesis of idiopathic pulmonary fibrosis ...
Jie Huang, Nana Liu, Yueyue Jin, Shuangyu Han, Lian Li, Yunze Du, Luqing Wei, Dongsheng Li, Yan Zhang, Yubao Wang, Jau‐Shyong Hong, Wen Ning, Jing Feng   +12 more
wiley   +1 more source

Accuracy of direct gradient sensing by cell-surface receptors [PDF]

arXiv, 2009
Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv  

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

The Journal of Physiology, EarlyView.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia, Deborah Varro, Thomas Buffet, Olivier Marre   +3 more
wiley   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Frontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony, Bincy Baby, Ranjit Vijayan, Ranjit Vijayan, Ranjit Vijayan   +4 more
doaj   +1 more source

Development and Validation of a Gas Chromatography‐Mass Spectrometry Method for the Determination of Fentanyl and Butyryl Fentanyl in Oral Fluid

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Synthetic opioids are lab‐synthesized substances that target the brain's opioid receptors, offering analgesic and sedative effects. Amongst them, fentanyl is one of the most widely used to intervene in chronic pain in moderate to severe cancer situations. Butyryl fentanyl (BF) is a novel synthetic opioid whose use is growing.
Nicola Camedda, Sara Dagoli, Luca Anzillotti, Rossana Cecchi   +3 more
wiley   +1 more source

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice [PDF]

, 2015
Opiates have been used historically for the treatment of depression. Renewed interest in the use of opiates as antidepressants has focussed on the development of kappa opioid receptor (κ-receptor) antagonists.
Almatroudi, Abdulrahman, Bailey, Christopher P, Bailey, Sarah J, Husbands, Stephen M   +3 more
core   +1 more source

Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]

arXiv, 2012
Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv