Results 141 to 150 of about 18,176 (269)

The effects of opioids on the peripheral terminals of rat and guinea pig sensory neurons [PDF]

, 1990
Studies in vivo and in vitro suggest that opioids can modulate nociceptive signals by interacting with receptors on peripheral neurons.
Ketchum, Steven Blake
core  

Kappa Opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons [PDF]

, 2015
The endogenous dynorphin-κ opioid receptor (KOR) system encodes the dysphoric component of the stress response and controls the risk of depression-like and addiction behaviors; however, the molecular and neural circuit mechanisms are not understood.
Bruchas, Michael R, Chavkin, Charles, Ehrich, Jonathan M, Kieffer, Brigitte L, Knakal, Cerise R, Kuhar, Jamie R, Messinger, Daniel I, Phillips, Paul E M, Schatteuer, Selena S, Zweifel, Larry S   +9 more
core   +3 more sources

A Chimeric Analysis of the Opioid Receptor Domains Critical for the Binding Selectivity of μ Opioid Ligands

Neurobiology of Disease, 1996
The μ opioid receptor plays a key role in mediating the physiological, pharmacological, and behavioral effects of endogenous opioids and of opiate drugs such as morphine and heroin.
Brendon Watson, Fan Meng, Huda Akil
doaj  

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central
Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C. Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima   +4 more
doaj   +1 more source

Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. [PDF]

Protein Cell, 2023
Chen Y, Chen B, Wu T, Zhou F, Xu F.
europepmc   +1 more source

κ₁‐ and κ₂‐opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum [PDF]

, 1997
Anton N. M. Schoffelmeer, François Hogenboom, Arie H. Mulder   +2 more
openalex   +1 more source

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

MedComm, Volume 6, Issue 5, May 2025.
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie, Yuan Li, Xinyue Wang, Elena Blokhina, Evgeny Krupitsky, Marina Vetrova, Ji Hu, Ti‐Fei Yuan, Jue Chen, Hua Wang, Xiangfang Chen   +10 more
wiley   +1 more source

Characterization of BU09059:A novel potent selective κ-receptor antagonist [PDF]

, 2014
[Image: see text] Kappa-opioid receptor (κ) antagonists are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing κ-antagonists has been limited by the pharmacodynamic properties of prototypic κ-selective ...
Bailey, Sarah J, Casal-Dominguez, Joseph J, Clarke, Mary J, Furkert, Daniel, Husbands, Stephen M, Ostovar, Mehrnoosh, Teintang, Linnea, Traynor, John R   +7 more
core   +1 more source

Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity

Beilstein Journal of Organic Chemistry, 2013
The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket ...
Thomas A. Munro, Wei Xu, Douglas M. Ho, Lee-Yuan Liu-Chen, Bruce M. Cohen   +4 more
doaj   +1 more source

Opioids in cancer: The κ‑opioid receptor (Review). [PDF]

Mol Med Rep, 2022
Zhou Q, Zhang Z, Long S, Li W, Wang B, Liang N.   +5 more
europepmc   +1 more source