Results 21 to 30 of about 18,176 (269)
Pain and Therapy, 2020 Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid receptor agonists.
Jeffrey Gudin, Jeffrey Fudin
doaj +1 more source
Κ-opioid receptor stimulation improves endothelial function in hypoxic pulmonary hypertension. [PDF]
PLoS ONE, 2013 The present study was designed to investigate the effect of κ-opioid receptor stimulation with U50,488H on endothelial function and underlying mechanism in rats with hypoxic pulmonary hypertension (HPH).
Qi Wu +11 more
doaj +1 more source
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits
Experimental Dermatology, Volume 31, Issue 12, Page 1900-1907, December 2022., 2022 Abstract Modern genetic approaches in animal models have unveiled novel itch‐specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa‐opioid receptors (KORs) and mu‐opioid receptors (MORs) have been implicated in both the ...
Brian S. Kim +5 more
wiley +1 more source
GZ coupling to the rat κ-opioid receptor [PDF]
, 1995 We have expressed the cloned rat κ-opioid receptor in human embryonic kidney 293 cells and studied the ability of κ-selective ligands to inhibit adenylyl cyclase. In transfected 293 cells, activation of the κ-opioid receptor by U50,488 and the dynorphins
Lai, Helen W.L. +3 more
core +1 more source
Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain [PDF]
, 2006 The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation.
Kuraishi Yasushi +3 more
core +2 more sources
Molecules, 2021 Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic action is mediated by μ-, δ-, and κ-receptors, but currently, with few exceptions for k-agonists,
Sandra Piras +12 more
doaj +1 more source
Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022 Breast cancer (BC) is one of the most challenging cancers to treat. Nutraceuticals acting by attenuating Hedgehog, NF‐κB, and Wnt/β‐catenin pathways. Nutraceuticals have medical characteristics and may cure cancer Abstract Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many cancer‐related deaths.
Khalid Saad Alharbi +11 more
wiley +1 more source
Role of central opioid receptors on serotonin-Induced hypophagia in the neonatal broilers [PDF]
The Iranian Journal of Veterinary Science and Technology, 2022 Serotonin (5-HT) plays an underpinning role in appetite regulation and the opioid system has a role in the modulation of the ingestion behavior in birds.
Behrouz Rahmani +6 more
doaj +1 more source
The 2-Methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats [PDF]
, 2013 κ opioid receptor activation by traditional arylacetamide agonists and the novel neoclerodane diterpene κ opioid receptor agonist Salvinorin A (Sal A) results in attenuation of cocaine-seeking behavior in pre-clinical models of addiction.
Ewald, Amy +4 more
core +1 more source