Results 71 to 80 of about 9,562 (190)

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

Beilstein Journal of Organic Chemistry, 2007
There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds.
Thomas A. Munro, Katharine K. Duncan, Richard J. Staples, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon Jr., Bruce M. Cohen   +7 more
doaj   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Effectiveness of Psychosocial Interventions for Adults With Substance Use Disorder That Have a Co‐Occurring Common Mental Health Disorder: An Umbrella Review

Drug and Alcohol Review, Volume 45, Issue 1, January 2026.
ABSTRACT Issues People with substance use disorders can have co‐occurring mental disorders. Approach An umbrella review was conducted to identify evidence of the effectiveness of psychosocial interventions for adults (aged 18+) with substance use disorders and co‐occurring common mental health disorders.
Emma L. Simpson, Munira Essat, Ruth Wong, Sarah Stacey, Edward Day   +4 more
wiley   +1 more source

Effect of Dezocine and Dexmedetomidine as Adjuvants in Ropivacaine for Incision Subcutaneous Infiltration Anesthesia on Incision Healing in Diabetic Rats

Brain and Behavior, Volume 15, Issue 12, December 2025.
The adjunctive use of dezocine and dexmedetomidine with ropivacaine in incisional subcutaneous infiltration anesthesia may contribute to improved incision healing in diabetic rats. ABSTRACT Introduction Surgery can induce insulin resistance (IR) in diabetic patients, and severe IR compromises the body's ability to combat infection and shock, impairs ...
Lang Yu, Bin Gao, Lingling Sun, Jing Mu, Piaopiao Zhang, Qin Zhang, Huanzhong He, He Liu   +7 more
wiley   +1 more source

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Frontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony, Bincy Baby, Ranjit Vijayan, Ranjit Vijayan, Ranjit Vijayan   +4 more
doaj   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper, Daniela Hemsing, Julia Elisabett K. Bolsonello, Susana R. de Mello Schlemper, Tiago Tizziani, Lutuima A. Capangue Neto, Louis P. Sandjo   +6 more
wiley   +1 more source

Worldwide Research Trends on Substance Use Disorder‐Related Inflammatory Imbalances: A Bibliometric Analysis

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
A bibliometric analysis of worldwide research trends on “substance use disorder‐related inflammation”. “Neuroinflammation” is identified as a key research hotspot. The findings provide a data‐driven overview of the evolving landscape in this field. ABSTRACT Background Substance use disorder (SUD) is a complex, chronic, and relapsing encephalopathy ...
Shirui Cao, Longtao Yang, Ruixin Wang, Jun Liu   +3 more
wiley   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain

Cell Reports Medicine
Summary: The shortfall in new analgesic agents is a major impediment to reducing reliance on opioid medications for control of severe pain. In both animals and man, attenuating nociceptive transmission from primary afferent neurons with a μ-opioid ...
Ellen S. Staedtler, Matthew R. Sapio, Diana M. King, Dragan Maric, Andre Ghetti, Andrew J. Mannes, Michael J. Iadarola   +6 more
doaj   +1 more source