Results 71 to 80 of about 9,643 (193)

8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

Beilstein Journal of Organic Chemistry, 2007
There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds.
Thomas A. Munro, Katharine K. Duncan, Richard J. Staples, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon Jr., Bruce M. Cohen   +7 more
doaj   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Frontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony, Bincy Baby, Ranjit Vijayan, Ranjit Vijayan, Ranjit Vijayan   +4 more
doaj   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain

Cell Reports Medicine
Summary: The shortfall in new analgesic agents is a major impediment to reducing reliance on opioid medications for control of severe pain. In both animals and man, attenuating nociceptive transmission from primary afferent neurons with a μ-opioid ...
Ellen S. Staedtler, Matthew R. Sapio, Diana M. King, Dragan Maric, Andre Ghetti, Andrew J. Mannes, Michael J. Iadarola   +6 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa‐Opioid and 5‐HT2A/2C Receptor Agonists in Mice

Neuropsychopharmacology Reports
Aim The regulation of new psychoactive and dangerous abused substances is very important for the prevention of drug abuse. A simple and effective evaluation method using laboratory animals is needed to regulate designated drugs with high accuracy and ...
Hideaki Kato, Yoshimi Ichimaru, Masaaki Kurihara, Koushirou Sogawa, Masahiko Funada, Tsutomu Suzuki   +5 more
doaj   +1 more source