Results 11 to 20 of about 5,351 (154)
Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023 Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022 Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques +4 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 4, Page 569-583, December 2025.Accurate species identification is critical for conserving endangered Firmiana trees in China. However, morphological similarities among closely related Firmiana species complicate its taxonomic identification. We conducted genome skimming on 62 samples representing all 10 Chinese species and discovered nrITS as the optimal DNA barcode, achieving 100 ...
Li‐Jun Yan +8 more
wiley +1 more source
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
Morphological Observation and Transcriptome Analysis During True-vivipary Development in Mangrove Kandelia obovata [PDF]
, 2017 植物界中的胎生现象是指有性生殖产生的后代在母体上不经休眠或短暂休眠即萌发，以潮间带红树植物最为显著。虽然在形态结构、生理生化、生态适应等水平对红树植物的胎生现象已有所研究，但其涉及的分子机制仍未被阐明。本论文以我国广泛分布并具有重要生态学价值的显胎生红树代表物种秋茄(Kandeliaobovata)为研究材料，对从胚珠受精到胚轴掉落的一系列发育过程进行形态观察，确定具有转变性意义的阶段及组织，并对其中7个关键组织(受精后的胚胎、胚胎突出种皮前后的子叶及下胚轴 ...
周晓旋
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Methods in Ecology and Evolution, Volume 15, Issue 8, Page 1408-1421, August 2024.Abstract Environmental DNA (eDNA) monitoring of species distribution has become a critical tool in ecology, conservation biology and fisheries for identifying the presence and distribution of diverse organisms, including important, threatened and invasive species.
Jiwei Yang +4 more
wiley +1 more source
Analysis of Dvl function and expression patterns of Wnt/β-catenin signaling genes in amphioxus [PDF]
, 2015 Wnt/β-catenin信号通路是后生动物中一条相对保守的信号通路，广泛参与早期胚胎体轴的建立以及多种器官的形态建成与分化。该信号通路在很多物种中都已有研究，但是在脊索动物文昌鱼中该信号通路的研究才刚刚开始，研究的内容仅包括Wnts、β-catenin、Tcf、Axin、Dkks和sFRPs基因的表达谱分析以及化学试剂处理对胚胎发育的影响，在文昌鱼中关于该信号通路中很多重要基因的功能研究尚未开始。 本文鉴定和克隆了文昌鱼Wnt/β-catenin信号通路中的Dvl（Dishevelled）基因 ...
王净
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RBX1 regulates uveal melanoma immune-related genes via STAT1 [PDF]
, 2023 Objective·To investigate the role of RBX1 (ring-box protein 1) in the regulation of immune-related genes in uveal melanoma (UVM) tumor cells.Methods·The Cancer Genome Atlas (TCGA) was searched to analyze the expression levels of RBX1 in tumors and the ...
FAN Xianqun +4 more
core +1 more source
霍乱弧菌新发菌株中
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的探索霍乱弧菌新发菌株H1的六型分泌系统（T6SS）存在的转录调控机制。方法本研究以转录组测序为基础，分析H1株分别由于vipA敲除（H1ΔvipA），vipB敲除（H1ΔvipB）和clpV敲除（H1ΔclpV）时T6SS基因簇的转录水平，并对其差异基因进行了基因本体论（GO）富集和京都基因与基因组百科全书（KEGG）富集。结果发现H1ΔvipA有22个差异基因（FDR<0.01，|log2FC|≥1），其中有18个属于T6SS基因簇；并且除vipA外，其转录水平均呈上升趋势 ...
吴文轩, 郭扬, 张幸鼎, 赵文婧
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