Results 11 to 20 of about 4,245 (200)

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review [PDF]

Results in Chemistry
1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities.
Hussam Elddin Nabeih Khasawneh, Ali Abdulrazzaq Abdulhussein Alrikabi, Amran M. AL-Erjan, Mustafa Jawad Kadham, Raed Fanoukh Aboqader Al-Aouadi, Natrayan Lakshmaiya, Roziyeva Muhayyo, Stefan Bräse, Hadeer M. Farhan   +8 more
doaj   +3 more sources

New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity. [PDF]

Mar Drugs, 2019
New analogs of nortopsentin, a natural 2,4-bis(3′-indolyl)imidazole alkaloid, in which the central imidazole ring of the natural lead was replaced by a 1,2,4-oxadiazole moiety, and in which a 7-azaindole portion substituted the original indole moiety, were efficiently synthesized.
Cascioferro S, Attanzio A, Di Sarno V, Musella S, Tesoriere L, Cirrincione G, Diana P, Parrino B.   +7 more
europepmc   +6 more sources

Dysregulation of Mycobacterium marinum ESX-5 Secretion by Novel 1,2,4-oxadiazoles

Biomolecules, 2023
The ESX-5 secretion system is essential for the viability and virulence of slow-growing pathogenic mycobacterial species. In this study, we identified a 1,2,4-oxadiazole derivative as a putative effector of the ESX-5 secretion system.
Vien Q. T. Ho, Mark K. Rong, Eva Habjan, Samantha D. Bommer, Thang V. Pham, Sander R. Piersma, Wilbert Bitter, Eelco Ruijter, Alexander Speer   +8 more
doaj   +1 more source

Recent advances on the nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials

Defence Technology, 2022
This review covers recent advances in the synthesis and energetic performance of nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials. These materials comprise of 1,2,4-oxadiazole subunit as a key structural motif linked to different nitrogen ...
Wen-Li Cao, Qamar-un-Nisa Tariq, Zhi-Min Li, Jun-Qing Yang, Jian-Guo Zhang   +4 more
doaj   +1 more source

The first metal complexes of 3,3'-bi-1,2,4-oxadiazole: A curiously ignored ligand [PDF]

, 2006
The crystal structure of 3,3'-bi-1,2,4-oxadiazole (1) reveals a planar centrosymmetric structure for this molecule in the solid state. It forms a mononuclear complex (3) with palladium(II) chloride, which is shown by X-ray crystallography to contain the ...
Richardson, C., Steel, P.J.
core   +4 more sources

An Exploration of the Inhibitory Mechanism of Rationally Screened Benzofuran-1,3,4-Oxadiazoles and-1,2,4-Triazoles as Inhibitors of NS5B RdRp Hepatitis C Virus through Pharmacoinformatic Approaches

Biomedicines, 2023
Benzofuran, 1,3,4-oxadiazole, and 1,2,4-triazole are privileged heterocyclic moieties that display the most promising and wide spectrum of biological activities against a wide variety of diseases. In the current study, benzofuran-1,3,4-oxadiazole BF1–BF7
Ali Irfan, Shah Faisal, Sajjad Ahmad, Muhammad Jawwad Saif, Ameer Fawad Zahoor, Samreen Gul Khan, Jamila Javid, Sami A. Al-Hussain, Muhammed Tilahun Muhammed, Magdi E. A. Zaki   +9 more
doaj   +1 more source

Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring [PDF]

, 2015
New fluorinated bent-core mesogens containing the 1,2,4-oxadiazole or 1,2,4-triazole nucleus have been synthesized taking advantage of the ANRORC (Addition of Nucleophile, Ring-Opening, Ring-Closure) reactivity of 5-perfluoroalkyl-1,2,4-oxadiazoles ...
Amaranatha, Buscemi, Buscemi, Buscemi, Buscemi, Buscemi, Fortuna, Francescangeli, Gallardo, Gallardo, Gallardo, Gortz, Hird, Keith, Link, Lo Celso, Mandracchia, Meunier, Pace, Palumbo, Palumbo, Palumbo, Palumbo, Palumbo, Palumbo Piccionello, Parra, Parra, Pelzl, Pelzl, Pibiri, Prasad, Reddy, Ros, Shanker, Shanker, Speetjens, Terenzi, Terenzi, Torgova, Traskovskis, Tschierske, Tschierske, Van der Plas, Zafiropoulos   +43 more
core   +1 more source

Therapeutic potential of oxadiazole or furadiazole containing compounds

BMC Chemistry, 2020
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as ...
Ankit Siwach, Prabhakar Kumar Verma
doaj   +1 more source

Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles

International Journal of Molecular Sciences, 2023
1,2,4-Oxadiazole is an essential motif in drug discovery represented in many experimental, investigational, and marketed drugs. This review covers synthetic methods that allow the conversion of different types of organic compounds into 1,2,4-oxadiazole at ambient temperature and the practical application of the latter approaches for the preparation of ...
Sergey V. Baykov, Anton A. Shetnev, Artem V. Semenov, Svetlana O. Baykova, Vadim P. Boyarskiy   +4 more
openaire   +2 more sources

Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles [PDF]

, 2011
A carbamoyl-substituted nitrile oxide was generated upon treatment of easily available 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with THF (not dried); the reaction proceeded efficiently even in the absence of any special reagents and reaction conditions ...
1020, 1021, 1022, 1023, 1024, 1025, 1026, 1027, Ariga, Masahiro, Hirao, Shotaro, Ise, Yumiko, Kobiro, Kazuya, Nishiwaki, Nagatoshi, Okajima, Yoshikazu, Saigo, Kazuhiko, Sawayama, Jun   +15 more
core   +1 more source