Results 51 to 60 of about 4,245 (200)

Bis-Oxadiazole Assemblies as NO-Releasing Anticancer Agents

Pharmaceutics
Background: Malignant pleural mesothelioma (MPM) is an aggressive, asbestos-associated cancer characterized by dysregulated nitric oxide (NO) signaling and increased NO levels that facilitate tumor progression. Paradoxically, this aberrant NO environment
Egor M. Matnurov, Irina A. Stebletsova, Alexander A. Larin, Jemma Arakelyan, Ivan V. Ananyev, Artem L. Gushchin, Leonid L. Fershtat, Maria V. Babak   +7 more
doaj   +1 more source

Diazole and triazole derivatives of castor oil extract: synthesis, hypoglycemic effect, antioxidant potential and antimicrobial activity

Grasas y Aceites, 2020
The ricinoleate triglyceride was extracted from castor-oil seeds grown in Algeria and isolated by catalytically methanolyse to methyl ricinoleate.
F. Taieb Brahimi, F. Belkhadem, B. Trari, A. A. Othman   +3 more
doaj   +1 more source

Synthetic strategies for 5- and 6-membered ring azaheterocycles facilitated by iminyl radicals [PDF]

, 2016
The author thanks EaStCHEM for financial support.The totality of chemical space is so immense that only a small fraction can ever be explored. Computational searching has indicated that bioactivity is associated with a comparatively small number of ring ...
Walton, John Christopher
core   +2 more sources

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. [PDF]

, 2016
With the ever-increasing instances of resistance to frontline TB drugs there is the need to develop novel strategies to fight the worldwide TB epidemic.
Abell, Chris, Baulard, Alain R, Blaszczyk, Michal, Blundell, Tom L, Brodin, Priscille, Delorme, Vincent, Nikiforov, Petar O, Surade, Sachin   +7 more
core   +2 more sources

Leaf Ethanol Extract of Dimocarpus longan Lour. Ameliorates Type 2 Diabetes Mellitus in Rats by Regulating Metabolic Pathways and Gut Microbiota

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Background The leaves of Dimocarpus longan Lour. are used unilaterally as Chinese herbal medicines to treat diabetes in Chongzuo and Hezhou, Guangxi, but the mechanism of its treatment of diabetes is not yet clear, and further research is needed. Methods This study examined the effects of leaf ethanol extract of D.s longan Lour.
Chunlian Lu, Piaoxue Zheng, Sisi Chen, Yanli Liang, Yuxin Jiang, Anqi Huo, Jingjing Xie, Jiawen Peng, Yuming Ma, Jiali Wei, Zhidong Ma, Hua Zhu, Jie Liang, Luis C. N. Da Silva   +13 more
wiley   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Preparation of perfluorinated 1,2,4-oxadiazoles [PDF]

, 1982
Fluorinated alkyl or alkylether 1,2,4 oxadiazole compounds are prepared by cyclizing the corresponding alkyl or alkylether imidoyl amidoximes in vacuo or in an inert atmosphere at a temperature within the range of 40 C to 100 C.
Ito, T. I., Kratzer, R. H., Paciorek, K. J. L., Rosser, R. W.   +3 more
core   +1 more source

Thiocarbamoylimidates as Precursors of New 5‐Amino‐1,2,4‐Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
1,2,4‐triazole and oxadiazole motifs are synthesized from thiocarbamoylimidates precursors, under mild conditions (40 °C) in the environmentally friendly water/ethanol reaction medium. The reaction is highly versatile and allows for the introduction of a wide variety of functional groups.
Oumaima Gatri, Thierry Roisnel, Marie Cordier, Vincent Dorcet, Mohamed Lotfi Efrit, Cédric Fischmeister   +5 more
wiley   +1 more source

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication [PDF]

, 2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has led to a pandemic, that continues to be a huge public health burden.
Ahmad, Shamshad, Arzel, Philippe, Bardiot, Dorothée, Canard, Bruno, Castermans, Karolien, Chaltin, Patrick, De Jonghe, Steven, Decroly, Etienne, Delpal, Adrien, dI&I I&I-1, Eydoux, Cecilia, Guillemot, Jean-Claude, Hilgenfeld, Rolf, Jochmans, Dirk, Klaassen, Hugo, Koukni, Mohamed, Lescrinier, Eveline, Leyssen, Pieter, Lyoo, Heyrhyoung, Marchand, Arnaud, Neyts, Johan, Robinson, Colin, Snijder, Eric J, Sub RvdM overig, Sun, Xinyuanyuan, van Hemert, Martijn J, van Kuppeveld, Frank, Vangeel, Laura, Virologie, Wanningen, Patrick, Zhang, Linlin, Zwaagstra, Marleen   +31 more
core   +7 more sources