Results 61 to 70 of about 31,516 (214)

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly, Abdulmajeed F. Alrefaei, Hossa F. Alshareef, Samar J. Almehmadi, Fatimah A. Alotaibi, Nadiyah M. Alshammari, Manal S. Ebaid, Hanadi A. Katouah   +7 more
wiley   +1 more source

Synthesis of new bipolar host materials based on 1,2,4-oxadiazole for blue phosphorescent OLEDs [PDF]

, 2014
Two novel bipolar host materials, namely 3,5-bis(4-(9H-carbazol-9-yl) phenyl)-1,2,4-oxadiazole (pCzmOXD) and 3,5-bis(3-(9H-carbazol-9-yl)phenyl)-1,2, 4-oxadiazole (mCzmOXD) were designed and synthesized, by incorporating a new block 1,2,4-oxadiazole as ...
Li, Qian, Cui, Lin Song, Dong, Shou Cheng, Zhong, Cheng, Jiang, Zuo Quan, Liao, Liang Sheng, Yuan, Xiao Dong   +6 more
core   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Synthesis and Synthetic Applications of 1,2,4-Oxadiazole-4-Oxides [PDF]

, 2007
The first 1,2,4-oxadiazole-4-oxide was prepared by Wieland a century ago, but-this compound remained largely a chemical curiosity until very recently.
CARAMELLA, PIERLUIGI, QUADRELLI, PAOLO
core  

Synthesis, characterisation and mesomorphic behaviours of non-symmetrically substituted 1,2,4- and 1,3,4-oxadiazole derivatives [PDF]

, 2017
Two series of non-symmetrically substituted bent-core mesogens derived from the central 3,5 and 2,5 cores of the 1,2,4- and 1,3,4-oxadiazole derivatives, respectively, containing ether and ester linkage have been synthesised by several straightforward ...
Ali Hussein R. Al-Daraji (3135585), Mazin M. Abdul Razzaq Al-Obaidy (3135582), Ivan Hameed R. Tomi (3135588)   +2 more
core   +1 more source

Asymmetric Design of Bipolar Host Materials with Novel 1,2,4-Oxadiazole Unit in Blue Phosphorescent Device [PDF]

, 2016
The intrinsic asymmetry of 1,2,4-oxadiazole was utilized to synthesize three isomers, DCzmOXD-1, DCzmOXD-2, and mCzmOXD, and high triplet energies over 2.80 eV made them good candidates for host materials in blue OLEDs. The best efficiencies of 23.0 cd A–
Liang-Sheng Liao (1586392), Lin-Song Cui (1594984), Zuo-Quan Jiang (1594987), Cheng Zhong (573294), Qian Li (114642)   +4 more
core   +1 more source

Synthesis, characterization and comparative study of mesomorphic properties of some new compounds containing both 1,2,4- and 1,3,4-oxadiazole moieties linked in the same molecule

Journal of Saudi Chemical Society, 2010
One new homologous series of compounds containing 1,2,4- and 1,3,4-oxadiazole rings in the same molecule was synthesized. 3-(4-Butoxyphenyl)-5-{4-[5-(4-alkoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-1,2,4-oxadiazole (VII)1–8 were synthesized by several ...
Ivan H.R. Tomi
doaj   +1 more source

Crystal structure, Hirshfeld analysis and a molecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]methyl}-2H-1,2,6-thiadiazine-4-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C15H22N4O5S, was prepared via alkylation of 3-(chloromethyl)-5-(pentan-3-yl)-1,2,4-oxadiazole in anhydrous dioxane in the presence of triethylamine. The thiadiazine ring has an envelope conformation with the S atom displaced by 0.4883 
Alexandre V. Ivachtchenko, Sergiy M. Kovalenko, Dmitry V. Kravchenko, Oleg D. Mitkin, Vladimir V. Ivanov, Thierry Langer   +5 more
doaj   +1 more source

Mechanistic Paths for the Gold(I)‐Catalyzed Heteroannulation of Salicylic Amides With Apolar Alkynes Explored With Density Functional Theory Calculations

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
A manifold of catalytic reaction paths can operate in the Au(I)‐catalyzed heteroannulation of salicylic amides and alkynes. However, a subtle initial nucleophilic advantage of N versus O and a kinetic bottleneck at an advanced stage of the mechanistic machinery seems to suffice for the reaction to run on a single path and with exquisite selectivity. We
Ioannis Stylianakis, Evaggelia Vlachou, Carlos Silva López, Antonios Kolocouris   +3 more
wiley   +1 more source

Diazole and triazole derivatives of castor oil extract: synthesis, hypoglycemic effect, antioxidant potential and antimicrobial activity

Grasas y Aceites, 2020
The ricinoleate triglyceride was extracted from castor-oil seeds grown in Algeria and isolated by catalytically methanolyse to methyl ricinoleate.
F. Taieb Brahimi, F. Belkhadem, B. Trari, A. A. Othman   +3 more
doaj   +1 more source