Results 61 to 70 of about 40,557 (208)

Integrated Experimental, Chemometric, and In Silico Analyses of Larvicidal Supercritical Extracts From Myrtaceae Species Against Aedes aegypti

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The cross‐validated regression tree showed modest predictive performance. Mortality was not significantly associated with the first two PCA axes. Molecular modeling generated testable ligand–target hypotheses. Psidium cattleianum had lower LD50. The larvicidal activity of the crude extracts could not be attributed to individual constituents.
Ubiratan Alegransi Bones, Regiane Chiamente Pessetti, Gilberto Diniz Cozzer, Iuri Raiel Giacomelli, Maike Valentim Buzatto, Walter Antônio Roman Junior, Renan de Souza Rezende, Jacir Dal Magro, Vanessa da Silva Corralo   +8 more
wiley   +1 more source

The urinary metabolites of 5-(2-diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole

, 1964
The urine of mice, rats, dogs, and men treated with 5-(2-diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole has been examined for metabolic products of the drug.
P Ridolfi, B Catanese, G Corsi, B Silvestrini   +3 more
core   +1 more source

1,2,4-Oxadiazole Rearrangements Involving an NNC Side-Chain Sequence

, 2016
The thermal rearrangement of N-1,2,4-oxadiazol-3-yl-hydrazones into 1,2,4-triazole derivatives is reported. This represents the first example of a three-atom side-chain rearrangement involving an NNC sequence linked at the C(3) of the oxadiazole.
Antonio Palumbo Piccionello (564720), Nicolò Vivona (2243308), Andrea Pace (1309779), Silvestre Buscemi (2067370)   +3 more
core   +2 more sources

RuPhos Pd G4: A catalyst for Suzuki-Miyaura coupling reactions involving 1,2,4-oxadiazoles

Results in Chemistry
The 1,2,4-oxadiazole motif is highly significant in biological studies. An efficient Suzuki-Miyaura coupling methodology has been developed, catalyzed by RuPhos Pd G4, for 1,2,4-oxadiazole substrates This method achieves high yields and clean reactions ...
Deepak Kumar, Soumya Singh, Ganesh Jaysing Shinde, Suryakanta Dalai, Abhineet Vermaa, Girish Chandra Sharma, Mukesh Jangir   +6 more
doaj   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu, Jan Niclas Ludwig, Patrick Wolf Antoni, David Tymann, Max Martin Hansmann   +4 more
wiley   +2 more sources

π–π Noncovalent Interaction Involving 1,2,4- and 1,3,4-Oxadiazole Systems: The Combined Experimental, Theoretical, and Database Study

Molecules, 2021
A series of N-pyridyl ureas bearing 1,2,4- (1a, 2a, and 3a) and 1,3,4-oxadiazole moiety (1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as well as X-ray diffraction.
Sergey V. Baykov, Alexander S. Mikherdov, Alexander S. Novikov, Kirill K. Geyl, Marina V. Tarasenko, Maxim A. Gureev, Vadim P. Boyarskiy   +6 more
doaj   +1 more source

Oxadiazolone‐Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II‐Induced Vascular Contraction

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Larissa F. L. Ferreira, Daiana G. de A. Vasconcelos, Ruth C. A. Santos, Jivaldo G. Ferreira, Alice V. Araújo, Janaína V. dos Anjos   +5 more
wiley   +1 more source

Synthesis and properties of 5,5′-dinitramino-3,3′-bi(1,2,4-oxadiazole) and its energetic salts

, 2018
In order to develop high energy density materials, 5,5′-dinitramino-3,3′-bi(1,2,4-oxadiazole) (3, DNABO), a new heterocyclic energetic compound, was synthesized by the simple nitration of 5,5′-diamino-3,3′-bi(1,2,4-oxadiazole) (2) with 95% fuming nitric ...
Haifeng Huang, Yupeng Cao, Xuedong Gong, Xiangyang Lin, Jun Yang   +4 more
core   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan, Meenakshi Kaira, Sucheta Singh, Hrithik Dey, Kailash C. Pandey   +4 more
wiley   +1 more source

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source