Results 81 to 90 of about 101,287 (245)

1,2,4-Oxadiazole Rearrangements Involving an NNC Side-Chain Sequence

, 2016
The thermal rearrangement of N-1,2,4-oxadiazol-3-yl-hydrazones into 1,2,4-triazole derivatives is reported. This represents the first example of a three-atom side-chain rearrangement involving an NNC sequence linked at the C(3) of the oxadiazole.
Antonio Palumbo Piccionello (564720), Nicolò Vivona (2243308), Andrea Pace (1309779), Silvestre Buscemi (2067370)   +3 more
core   +1 more source

DEVELOPMENT AND VALIDATION OF THE METHOD FOR DETERMINING THE QUANTITATIVE CONTENT 5-[2-(3-TRET-BUTYLAMINO-2-HYDROXYPROPOXY)PHENOXYMETHYL]-3-METHYL-1,2,4-OXADIAZOLEHYDROCHLORIDE IN OCULAR DRUG FILMS FOR THE TREATMENT OF OPEN-ANGLE GLAUCOMA

Разработка и регистрация лекарственных средств, 2019
Developed method for the quantitative determination of 5-[2-(3-tret-butylamino-2-hydroxypropoxy) phenoxymethyl]-3-methyl-1,2,4-oxadiazole hydrochloride in polymer drug films by UV-spectrometry.
M. V. Bolshakova, M. A. Burakova, B. O. Alekseev   +2 more
doaj  

Synthesis, Characterization, and Evaluation of Energetic Properties of 1,2‐bis(5‐(Trifluoromethyl)‐4H‐1,2,4‐triazol‐3‐yl)Diazene

Propellants, Explosives, Pyrotechnics, Volume 50, Issue 11-12, Page 40-46, December 2025.
ABSTRACT A new azo‐bridged compound with triazole moieties featuring trifluoromethyl groups was synthesized, exhibiting encouraging properties in the field of energetic materials. The new compound was synthesized in two steps from common starting materials using cyclocondensation, followed by oxidation reaction.
Navid Rahman, Klas Meyer, Werner Kraus, Thomas M. Klapötke, Tomasz G. Witkowski   +4 more
wiley   +1 more source

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole

, 2011
Funding: University of St. Andrews and the Engineering and Physical Science Research Council (EPSRC, UK).The title compound, C15H12N2O, adopts the expected near-planar geometry, the phenyl and tolyl rings being inclined relative to the oxadiazole ring by
Woollins, J. Derek, Cordes, David B., David B. Cordes, J. Derek Woollins, Hua, Guoxiong, Alexandra M. Z. Slawin, Slawin, Alexandra M. Z., Guoxiong Hua   +7 more
core   +1 more source

Identification of New CD36 Antagonists by Structure‐Based Virtual Screening

Chemical Biology &Drug Design, Volume 106, Issue 5, November 2025.
Virtual screening identified drug‐like molecules as potential CD36 antagonists; some of them inhibited CD36 function in relevant cellular models. These antagonists could drive the development of CD36‐targeted therapies. ABSTRACT CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low‐density lipoproteins.
Sandra L. Guerrero‐Rodríguez, Luis Córdova‐Bahena, Fabiola Cortés‐Mendoza, Angel J. Ruiz‐Moreno, Cecilia Mata‐Cruz, Mireya Velázquez‐Paniagua, Nohemí Salinas‐Jazmín, Martín González‐Andrade, Marco A. Velasco‐Velázquez   +8 more
wiley   +1 more source

1,2,4-Oxadiazole Rearrangements Involving an NNC Side-Chain Sequence

, 2009
The thermal rearrangement of N-1,2,4-oxadiazol-3-yl-hydrazones into 1,2,4-triazole derivatives is reported. This represents the first example of a three-atom side-chain rearrangement involving an NNC sequence linked at the C(3) of the oxadiazole.
PALUMBO PICCIONELLO, Antonio, BUSCEMI, Silvestre, VIVONA, Nicolo', PACE, Andrea   +3 more
core   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

New potential biologically active compounds: Synthesis and characterization of urea and thiourea derivativpes bearing 1,2,4-oxadiazole ring

, 2020
Background: Urea, thiourea, and 1,2,4-oxadiazole compounds are of great interest due to their different activities such as anti-inflammatory, antiviral, analgesic, fungicidal, herbicidal, diuretic, antihelminthic and antitumor along with antimicrobial ...

core   +1 more source

Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
This review article looks at new synthetic xanthine oxidase inhibitors discovered in the last 5 years (2025–2020). It covers an analysis of the advances, structural diversity, biological potential of the molecules investigated and future prospects in drug development.
Giorgio Antoniolli, Gabriel Rodrigues de Moraes, Rafael Porreca Neves da Costa, Giovani Augusto Rosendo de Campos, Fernando Coelho   +4 more
wiley   +1 more source

Synthesis and properties of 5,5′-dinitramino-3,3′-bi(1,2,4-oxadiazole) and its energetic salts

, 2018
In order to develop high energy density materials, 5,5′-dinitramino-3,3′-bi(1,2,4-oxadiazole) (3, DNABO), a new heterocyclic energetic compound, was synthesized by the simple nitration of 5,5′-diamino-3,3′-bi(1,2,4-oxadiazole) (2) with 95% fuming nitric ...
Haifeng Huang, Yupeng Cao, Xuedong Gong, Xiangyang Lin, Jun Yang   +4 more
core   +1 more source