Results 81 to 90 of about 31,516 (214)

Thiocarbamoylimidates as Precursors of New 5‐Amino‐1,2,4‐Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
1,2,4‐triazole and oxadiazole motifs are synthesized from thiocarbamoylimidates precursors, under mild conditions (40 °C) in the environmentally friendly water/ethanol reaction medium. The reaction is highly versatile and allows for the introduction of a wide variety of functional groups.
Oumaima Gatri, Thierry Roisnel, Marie Cordier, Vincent Dorcet, Mohamed Lotfi Efrit, Cédric Fischmeister   +5 more
wiley   +1 more source

An interesting ring cleavage of a 1,2,4-oxadiazole ring [PDF]

, 2017
Ring-opening reaction: owing to the instability of the 1,2,4-oxadiazole ring under acidic conditions, unexpected compounds 2 and 3 were obtained. Compound 2 exhibits an oxygen balance of zero, density of 1.89 g cm−1 and detonation velocity of 9307 m s−1 ...
Hongwei Yang, Xuehai Ju, Qiong Yu, Guangbin Cheng, Chunxu Lu   +4 more
core   +1 more source

Synthesis of a Novel 1,2,4-Oxadiazole Diterpene from the Oxime of the Methyl Ester of 1β,13-Epoxydihydroquinopimaric Acid

Natural Product Communications, 2016
Oximation of the dihydroquinopimaric acid O -cyanoethylderivative ( 2 ) via the amidoxime 3 , and cyclization with trifluoroacetic anhydride resulted in a new 1,2,4-oxadiazole diterpenoid ( 4 ).
Elena V. Tretyakova, Elena V. Salimova, Victor N. Odinokov, Usein M. Dzhemilev   +3 more
doaj   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

UNUSUAL WAY OF REACTION OF 3-AMINO-4-(5-CHLOROMETHYL-1,2,4-OXADIAZOLE-3-YL)-FURAZAN WITH HYDRAZINE [PDF]

, 2017
The results of our study of the pathways of selective reactivity of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan versus 5-unsubstituted or 5-methyl and 5-trifluoromethyl substituted 4-(5R-1,2,4-oxadiazole-3-yl)furazans (R = H, Me, CF3) towards
Elena V. Stepanova, Andrei I. Stepanov
core   +1 more source

3-Phenyl-4-{3-[(p-tolyloxy)methyl]-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl}sydnone

Acta Crystallographica Section E, 2010
In the title compound (systematic name: 3-phenyl-4-{3-[(p-tolyloxy)methyl]-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl}-1,2,3-oxadiazol-3-ium-5-olate), C20H16N6O3S, an intramolecular C—H...O hydrogen bond generates an S(6) ring motif.
Jia Hao Goh, Hoong-Kun Fun, Nithinchandra, B. Kalluraya   +3 more
doaj   +1 more source

Recovery of Liquid Organic Radioactive Waste Absorbed Into Soil by Extraction

CleanMat, Volume 2, Issue 4, Page 285-296, December 2025.
Radioactive organic liquid waste adsorbed in soil containing pure beta‐emitting radionuclides such as H‐3 must be radiologically characterized for subsequent management. For this purpose, a method for the recovery of radioactive scintillation liquids adsorbed in soil has been developed that simulates this type of waste.
Fabiola Monroy‐Guzman, Yurihelem Jacobo Cruz, Thelma Selene Jiménez Bravo, Ignacio Alfredo Rivero Espejel, Jorge Anguiano Arévalo, María Dolores Tenorio Castillejos   +5 more
wiley   +1 more source

5-(1H-1,2,3-Benzotriazol-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole [PDF]

, 2008
In the title molecule, C15H11N5O, the 1,2,3-benzotriazole and 3-phenyl-1,2,4-oxadiazole units are individually essentially planar and the dihedral angle between them is 80.2 (2)°.
Shu-Qing Xu, Jia-Ming Li
core   +1 more source

A Critical Examination of Synthetic Approaches and Pharmacological Profiles of 1,2,4-Oxadiazole Derivatives [PDF]

<p><strong><span>Background:</span></strong><span> </span></p> <p><span>The previous study about the 1,2,4-oxadiazole heterocyclic ring for its distinctive bio-isosteric characteristics and ...
Priyanka B. Khedekar*, Shweta V. Rane, Namrata D. Dhote, Dhanshree Bawane , Aniket Murkute , Alpana j. Asnani , Datta Avhad
core   +1 more source

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

Molecules, 2014
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as
Mohamed M. El Sadek, Nagwa S. Abd El-Dayem, Seham Y. Hassan, Mohamed A. Mostafa, Galila A. Yacout   +4 more
doaj   +1 more source