Results 81 to 90 of about 40,557 (208)

Diazole and triazole derivatives of castor oil extract: synthesis, hypoglycemic effect, antioxidant potential and antimicrobial activity

Grasas y Aceites, 2020
The ricinoleate triglyceride was extracted from castor-oil seeds grown in Algeria and isolated by catalytically methanolyse to methyl ricinoleate.
F. Taieb Brahimi, F. Belkhadem, B. Trari, A. A. Othman   +3 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly, Abdulmajeed F. Alrefaei, Hossa F. Alshareef, Samar J. Almehmadi, Fatimah A. Alotaibi, Nadiyah M. Alshammari, Manal S. Ebaid, Hanadi A. Katouah   +7 more
wiley   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF THE METHOD FOR DETERMINING THE QUANTITATIVE CONTENT 5-[2-(3-TRET-BUTYLAMINO-2-HYDROXYPROPOXY)PHENOXYMETHYL]-3-METHYL-1,2,4-OXADIAZOLEHYDROCHLORIDE IN OCULAR DRUG FILMS FOR THE TREATMENT OF OPEN-ANGLE GLAUCOMA

Разработка и регистрация лекарственных средств, 2019
Developed method for the quantitative determination of 5-[2-(3-tret-butylamino-2-hydroxypropoxy) phenoxymethyl]-3-methyl-1,2,4-oxadiazole hydrochloride in polymer drug films by UV-spectrometry.
M. V. Bolshakova, M. A. Burakova, B. O. Alekseev   +2 more
doaj  

Síntese de materiais orgânicos funcionais derivados do heterociclo 1,2,4-oxadiazol [PDF]

, 2008
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Este trabalho tem como objetivo geral a síntese de moléculas simétricas curvadas contendo o heterociclo 1,2,4 oxadiazol, bem como o ...
FERREIRA, Marli
core  

Synthesis of a Novel 1,2,4-Oxadiazole Diterpene from the Oxime of the Methyl Ester of 1β,13-Epoxydihydroquinopimaric Acid

Natural Product Communications, 2016
Oximation of the dihydroquinopimaric acid O -cyanoethylderivative ( 2 ) via the amidoxime 3 , and cyclization with trifluoroacetic anhydride resulted in a new 1,2,4-oxadiazole diterpenoid ( 4 ).
Elena V. Tretyakova, Elena V. Salimova, Victor N. Odinokov, Usein M. Dzhemilev   +3 more
doaj   +1 more source

Synthesis and Synthetic Applications of 1,2,4-Oxadiazole-4-Oxides

, 2007
The first 1,2,4-oxadiazole-4-oxide was prepared by Wieland a century ago, but-this compound remained largely a chemical curiosity until very recently.
CARAMELLA, PIERLUIGI, QUADRELLI, PAOLO
core  

BIOLOGICALLY ACTIVE OXADIAZOLE [PDF]

, 2015
As we know that, Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring and is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogen (-N=) [1,2]. There are
Shukla, Chhama, Srivastava, Sanchit
core   +1 more source

The preparation and rearrangement of 3- pyridyl-4-alkyl (or aryl)-1,2,4- oxadiazole-5 (4h)-thiones

, 1991
3-Pyridyl-4-alkyl (or aryl)-1,2,4-oxadiazole-5(4H)-thiones are prepared by the reaction of N-alkyl (or aryl) pyridine carboxamide oximes with thiophosgene.
Ağırbaş, Hikmet, Dürüst, Yaşar, AGIRBAS, H, DURUST, Y, SUMENGEN, D   +4 more
core   +1 more source