Results 71 to 80 of about 40,557 (208)

Synthesis, characterization and comparative study of mesomorphic properties of some new compounds containing both 1,2,4- and 1,3,4-oxadiazole moieties linked in the same molecule

Journal of Saudi Chemical Society, 2010
One new homologous series of compounds containing 1,2,4- and 1,3,4-oxadiazole rings in the same molecule was synthesized. 3-(4-Butoxyphenyl)-5-{4-[5-(4-alkoxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-1,2,4-oxadiazole (VII)1–8 were synthesized by several ...
Ivan H.R. Tomi
doaj   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan, Ayşe Karagüzel, Miyase Gözde Gündüz   +2 more
wiley   +1 more source

Synthesis of new bipolar host materials based on 1,2,4-oxadiazole for blue phosphorescent OLEDs

, 2014
Two novel bipolar host materials, namely 3,5-bis(4-(9H-carbazol-9-yl) phenyl)-1,2,4-oxadiazole (pCzmOXD) and 3,5-bis(3-(9H-carbazol-9-yl)phenyl)-1,2, 4-oxadiazole (mCzmOXD) were designed and synthesized, by incorporating a new block 1,2,4-oxadiazole as ...
Li, Qian, Cui, Lin Song, Dong, Shou Cheng, Zhong, Cheng, Jiang, Zuo Quan, Liao, Liang Sheng, Yuan, Xiao Dong   +6 more
core   +1 more source

Data_Sheet_1_A Family of Energetic Materials Based on 1,2,4-Oxadiazole and 1,2,5-Oxadiazole Backbones With Low Insensitivity and Good Detonation Performance.pdf

, 2020
Design and synthesis of new compounds with both high detonation performances and good safety properties have always been a formidable task in the field of energetic materials.
Sheng-yong Zhang (8472192), Lian-jie Zhai (8472186), Huan Huo (7144328), Qi Xue (1867036), Fu-qiang Bi (8472180), Jun-lin Zhang (8472183), Zi-jun Wang (8324772), Bo-zhou Wang (8472189)   +7 more
core   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity [PDF]

, 2019
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor ...
BARBARA PARRINO, GODEFRIDUS J. PETERS, PATRIZIA DIANA, STELLA CASCIOFERRO, DANIELA CARBONE, ELISA GIOVANNETTI, GIROLAMO CIRRINCIONE   +6 more
core  

The Solid‐State Emission of AIPE‐Active Tricarbonylrhenium(I) Complexes Shifts to the Red: The Unexpected Performance of Triphenylphosphine Derivatives

Aggregate, Volume 7, Issue 7, July 2026.
New phosphino tricarbonylrhenium(I) complexes have efficient red emission in the aggregate and solid states. The good photostability and the vast possibilities of chemical modifications make these Re‐based complexes the starting point of a new generation of red emitters with aggregation‐induced phosphorescence emission (AIPE) characteristics.
Valentine Guilbaud, Mariusz Wolff, Maëlle Deleuzière, Evelyne Delfourne, Corinne Vanucci‐Bacqué, Charles‐Louis Serpentini, Sonia Mallet‐Ladeira, Eric Benoist, Suzanne Fery‐Forgues   +8 more
wiley   +1 more source

Exploiting the energetic potential of 1,2,4-oxadiazole derivatives: combining the benefits of a 1,2,4-oxadiazole framework with various energetic functionalities

, 2017
A series of 1,2,4-oxadiazole derived energetic compounds were synthesized and structurally characterized, some of which have the potential as melt-cast explosives or secondary explosives.
Chao Yan, Tianlin Liu, Kangcai Wang, Hongwei Yang, Guangbin Cheng, Qinghua Zhang   +5 more
core   +1 more source

Crystal structure, Hirshfeld analysis and a molecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]methyl}-2H-1,2,6-thiadiazine-4-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C15H22N4O5S, was prepared via alkylation of 3-(chloromethyl)-5-(pentan-3-yl)-1,2,4-oxadiazole in anhydrous dioxane in the presence of triethylamine. The thiadiazine ring has an envelope conformation with the S atom displaced by 0.4883 
Alexandre V. Ivachtchenko, Sergiy M. Kovalenko, Dmitry V. Kravchenko, Oleg D. Mitkin, Vladimir V. Ivanov, Thierry Langer   +5 more
doaj   +1 more source

2‐Pyrazoline‐5‐One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevgi Kocyigit Sevinc, Ş. Güniz Küçükgüzel, Sevim Rollas, Fulya Yukcu   +3 more
wiley   +1 more source