Results 61 to 70 of about 4,245 (200)

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

Synthesis of new 3-(4-methyl-2-arylthiazol-5-yl)-5-aryl-1,2,4-oxadiazole derivatives as potential cytotoxic and antimicrobial agents

European Journal of Medicinal Chemistry Reports, 2022
Globally cancer is the second leading cause of death; a drug that can cure cancer with the utmost negligible side effects is still a distant goal. Due to increasing antibiotic resistance, microbial infection remains a grave global health security threat.
Abdul Latif N. Shaikh, Abhijit Shinde, Abhijit Chavan, Rajendra Patil, Vivek Bobade, Pravin C. Mhaske   +5 more
doaj   +1 more source

Synthesis and Antibacterial Activity of Mono- and Bi-Cationic Pyridinium 1,2,4-Oxadiazoles and Triazoles [PDF]

, 2023
One of the main causes of mortality in humans continues to be infectious diseases. Scientists are searching for new alternatives due to the fast increase in resistance of some harmful bacteria to the frontline antibiotics. To effectively treat pathogenic
Amata S., Buscemi S., Cala C., Palumbo Piccionello A., Pibiri I., Pizzo M., Rizzo C.   +6 more
core   +1 more source

3-(2,4-Dichlorophenyl)-5-methyl-1,2,4-oxadiazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
Dans le composé du titre, C9H6Cl2N2O, l'angle dièdre entre les cycles oxadiazole et benzène est de 1,7 (2) °. Dans le cristal, les molécules sont liées en chaînes le long de l'axe b par de courts contacts intermoléculaires Cl ́ O [3,019 (3) Å].
Hoong‐Kun Fun, Mohd Mustaqim Rosli, Sankappa Rai, Arun M. Isloor, Prakash Shetty   +4 more
openaire   +3 more sources

Recovery of Liquid Organic Radioactive Waste Absorbed Into Soil by Extraction

CleanMat, Volume 2, Issue 4, Page 285-296, December 2025.
Radioactive organic liquid waste adsorbed in soil containing pure beta‐emitting radionuclides such as H‐3 must be radiologically characterized for subsequent management. For this purpose, a method for the recovery of radioactive scintillation liquids adsorbed in soil has been developed that simulates this type of waste.
Fabiola Monroy‐Guzman, Yurihelem Jacobo Cruz, Thelma Selene Jiménez Bravo, Ignacio Alfredo Rivero Espejel, Jorge Anguiano Arévalo, María Dolores Tenorio Castillejos   +5 more
wiley   +1 more source

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase [PDF]

, 2015
N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity ...
Barker, KV, Brannigan, JA, Heal, WP, Leatherbarrow, RJ, Paape, D, Rackham, MD, Smith, DF, Tate, EW, Wilkinson, AJ, Yu, Z   +9 more
core   +1 more source

3-(2,4-Dichlorophenyl)-5-phenyl-1,2,4-oxadiazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
في مركب العنوان، C14H8Cl2N2O، تكون الزوايا ثنائية السطوح بين مستوى حلقة الأكساديازول وتلك الخاصة بحلقات البنزين 2.3 (1) و 9.5 (1)درجة. في البلورة، ترتبط الجزيئات في سلاسل على طول المحور c بواسطة تفاعلات C- H - CL. هذه السلاسل مكدسة على طول المحور.
Hoong‐Kun Fun, Mohd Mustaqim Rosli, Sankappa Rai, Arun M. Isloor, Prakash Shetty   +4 more
openaire   +3 more sources

Multi‐channel charge transfer delayed fluorescence enabling high‐efficiency organic light‐emitting diodes

FlexMat, Volume 2, Issue 4, Page 533-581, December 2025.
The enhanced utilization of triplet excitons is a central theme in the evolution of organic luminescent materials. This review sums up recent research on multi‐channel charge transfer delayed fluorescence molecules, which exhibit a unique distribution of excited‐state energy levels, thereby enhancing the utilization rate of triplet excitons and ...
Guo‐Wei Chen, Zhen Zhang, Xin‐Yi Zeng, Yi‐Hui He, Guo Yuan, Yan‐Qing Li, Jian‐Xin Tang   +6 more
wiley   +1 more source

Synthesis, Characterization, and Evaluation of Energetic Properties of 1,2‐bis(5‐(Trifluoromethyl)‐4H‐1,2,4‐triazol‐3‐yl)Diazene

Propellants, Explosives, Pyrotechnics, Volume 50, Issue 11-12, Page 40-46, December 2025.
ABSTRACT A new azo‐bridged compound with triazole moieties featuring trifluoromethyl groups was synthesized, exhibiting encouraging properties in the field of energetic materials. The new compound was synthesized in two steps from common starting materials using cyclocondensation, followed by oxidation reaction.
Navid Rahman, Klas Meyer, Werner Kraus, Thomas M. Klapötke, Tomasz G. Witkowski   +4 more
wiley   +1 more source

3-Phenyl-4-{3-[(p-tolyloxy)methyl]-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl}sydnone

Acta Crystallographica Section E, 2010
In the title compound (systematic name: 3-phenyl-4-{3-[(p-tolyloxy)methyl]-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl}-1,2,3-oxadiazol-3-ium-5-olate), C20H16N6O3S, an intramolecular C—H...O hydrogen bond generates an S(6) ring motif.
Jia Hao Goh, Hoong-Kun Fun, Nithinchandra, B. Kalluraya   +3 more
doaj   +1 more source