Results 71 to 80 of about 4,245 (200)

Identification of New CD36 Antagonists by Structure‐Based Virtual Screening

Chemical Biology &Drug Design, Volume 106, Issue 5, November 2025.
Virtual screening identified drug‐like molecules as potential CD36 antagonists; some of them inhibited CD36 function in relevant cellular models. These antagonists could drive the development of CD36‐targeted therapies. ABSTRACT CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low‐density lipoproteins.
Sandra L. Guerrero‐Rodríguez, Luis Córdova‐Bahena, Fabiola Cortés‐Mendoza, Angel J. Ruiz‐Moreno, Cecilia Mata‐Cruz, Mireya Velázquez‐Paniagua, Nohemí Salinas‐Jazmín, Martín González‐Andrade, Marco A. Velasco‐Velázquez   +8 more
wiley   +1 more source

Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules. [PDF]

, 2011
Carbon monoxide (CO) is a weak soluble guanylyl cyclase stimulator, leading to transient increases in cGMP and vasodilation. The aim of the present work was to measure the effect of CO-releasing molecules (CORMs) on the cGMP/nitric oxide (NO) pathway ...
Baskaran P, Beuve A, BUCCI, MARIAROSARIA, CIRINO, GIUSEPPE, Coletta C, Gonçalves AM, Guerreiro B, Marazioti A, Marques AR, Papapetropoulos A., Romão CC, Seixas JD, Szabó C, VELLECCO, VALENTINA   +13 more
core   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Design and Synthesis of New A2B Adenosine Receptor Antagonists [PDF]

, 2009
Starting from chemical structure of N-benzo-[1,3]dioxol-5-yl-2-[5-(2,6dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol3-yloxy]-acetamide, MRE2029F20* various structural modifications were realized to afford a new series of A2B ...
BARALDI, Stefania
core  

A facile synthesis of N-Z/Boc-protected 1,3,4-oxadiazole-based peptidomimetics employing peptidyl thiosemicarbazides [PDF]

, 2010
Synthesis of 1,3,4-oxadiazole containing peptidomimetics is described by a p-TsCl/pyridine-mediated cyclization of the corresponding dipeptidyl thiosemicarbazides, which are readily prepared by coupling N-protected amino acid hydrazides with amino acid ...
Lamani, R.S., Nagendra, G., Sureshbabu, V.V.   +2 more
core   +1 more source

Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
This review article looks at new synthetic xanthine oxidase inhibitors discovered in the last 5 years (2025–2020). It covers an analysis of the advances, structural diversity, biological potential of the molecules investigated and future prospects in drug development.
Giorgio Antoniolli, Gabriel Rodrigues de Moraes, Rafael Porreca Neves da Costa, Giovani Augusto Rosendo de Campos, Fernando Coelho   +4 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF THE METHOD FOR DETERMINING THE QUANTITATIVE CONTENT 5-[2-(3-TRET-BUTYLAMINO-2-HYDROXYPROPOXY)PHENOXYMETHYL]-3-METHYL-1,2,4-OXADIAZOLEHYDROCHLORIDE IN OCULAR DRUG FILMS FOR THE TREATMENT OF OPEN-ANGLE GLAUCOMA

Разработка и регистрация лекарственных средств, 2019
Developed method for the quantitative determination of 5-[2-(3-tret-butylamino-2-hydroxypropoxy) phenoxymethyl]-3-methyl-1,2,4-oxadiazole hydrochloride in polymer drug films by UV-spectrometry.
M. V. Bolshakova, M. A. Burakova, B. O. Alekseev   +2 more
doaj  

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) [PDF]

, 2014
N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme and an attractive drug target in parasitic infections such as malaria. We have previously reported that 2-(3-(piperidin-4-yloxy)benzo[b]thiophen-2-yl)-5-((1,3,5-trimethyl-1H-pyrazol-4-yl ...
Anthony A. Holder, Anthony J. Wilkinson, Bird C. W., Bissantz C., Bostrom J., Brand S., Brannigan J. A., Böhm H.-J., Delves M., Derbyshire E. R., Desjardins R. E., Dondorp A. M., Dossetter A. G., Dunitz J. D., Edward W. Tate, Emsley P., Evans P., Fidock D. A., Frearson J. A., Goldberg K., Goncalves V., Goncalves V., Griffen E., Hann M. M., Hopkins A. L., Hopkins A. L., James A. Brannigan, Kabsch W., Kaveri Rangachari, Kenny P. W., Keseru G. M., Leeson P. D., Mark D. Rackham, Meister S., Murray C. J. L., Murshudov G. N., Möskes C., Patwardhan P., Phyo A. P., Pino P., Poulin B., Rackham M. D., Rees-Channer R. R., Resh M. D., Ritchie T. J., Robin J. Leatherbarrow, Singh B., Stephan Meister, Tull D., Wager T. T., Waring M. J., Watjen F., Winter G., Wright M. H., Wright M. H., Yu Z., Yung-Chi C., Zhao H.   +57 more
core   +1 more source

Development of a Reliable Purity Method for Ataluren in a Sachet Formulation Through the Analysis of Its Stress Degradation Behavior Using HPLC, LC‐MS, and 2D‐NMR

SEPARATION SCIENCE PLUS, Volume 8, Issue 8, August 2025.
ABSTRACT Ataluren is a medication commonly used for Duchenne muscular dystrophy. Currently, it is available in granules for oral suspension. A unique reverse‐phase HPLC approach with a UV detector was established to detect and quantify ataluren and its degradation components in medicinal products. This technique utilized a phenyl hexyl stationary phase
Nagavardhana Reddy Vanga, Venkata Ratnam Kesamsetty, Kumarswamy Ummiti, Venkata Nadh Ratnakaram   +3 more
wiley   +1 more source

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

Molecules, 2014
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as
Mohamed M. El Sadek, Nagwa S. Abd El-Dayem, Seham Y. Hassan, Mohamed A. Mostafa, Galila A. Yacout   +4 more
doaj   +1 more source