Results 81 to 90 of about 4,245 (200)
ChemMedChem, Volume 20, Issue 13, July 1, 2025.Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali +11 more
wiley +1 more source
Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley +1 more source
European Journal of Organic Chemistry, Volume 28, Issue 20, May 28, 2025.New amphiphilic fluoro‐functionalized cellulosic materials are being yielded through nucleophilic aromatic substitution. Covalent attachment of fluorinated moiety into biopolymers is being assured with full characterization. Fluoro‐functionalized materials are being incorporated in alginate beads to remove organic pollutants from wastewater ...
Davide Ricci +9 more
wiley +1 more source
Fragment-based approaches to TB drugs. [PDF]
, 2018 Tuberculosis is an infectious disease associated with significant mortality and morbidity worldwide, particularly in developing countries. The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug ...
Abell, Chris +3 more
core +1 more source
Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
ACS Combinatorial Science, 2016 One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields.
Andrey, Tolmachev +10 more
openaire +2 more sources
ChemMedChem, Volume 20, Issue 9, May 5, 2025.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
4-[3-(Phenoxymethyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-3-(p-tolyl)sydnone
Acta Crystallographica Section E, 2010 In the title triazolothiadiazine derivative, C20H16N6O3S {systematic name: 3-(4-methylphenyl)-4-[3-(phenoxymethyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-1,2,3-oxadiazol-3-ium-5-olate}, an S(6) ring motif is generated by an intramolecular C&#
Jia Hao Goh +3 more
doaj +1 more source
A comparative study of bridged 1,2,4-oxazolones and their derivatives
Energetic Materials Frontiers, 2020 For energetic compounds, a slight difference in their molecular structures can result in a tremendous difference in their properties. Compounds with similar structures but exhibiting big difference in their physicochemical properties (such as density and
Teng Fei +3 more
doaj +1 more source
Quantum chemical calculations for polymers and organic compounds [PDF]
The relativistic effects of the orbiting electrons on a model compound were calculated. The computational method used was based on 'Modified Neglect of Differential Overlap' (MNDO).
Lopez, J., Yang, C.
core +1 more source
New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness [PDF]
, 2017 Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide ...
EDWARD W. TATE +4 more
core +1 more source