Results 71 to 80 of about 2,851 (224)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Исследование фармакологической активности 4-амино-5-(фуран-2-ил)-4Н-1,2,4-триазол-3-тиола при парацетамоловом гепатите [PDF]

, 2013
ПАРАЦЕТАМОЛ /вред воздГЕПАТИТ ЛЕКАРСТВЕННЫЙ ХРОНИЧЕСКИЙФУРАНЫАМИНЫТРИАЗОЛЫСУЛЬФГИДРИЛЬНЫЕ ...
Белай, И. М., Кныш, Е. Г., Михайлюк, Е. О., Панасенко, А. И., Парченко, В. В.   +4 more
core  

Computational and Experimental Analyses of the Synergistic Corrosion Inhibition of Green Phytochemicals Found in Yellow Bush in Acidic Media

Engineering Reports, Volume 8, Issue 1, January 2026.
Synergistic interaction was observed to exist between terpineol, 1,5,9‐undecatriene‐2,6,10‐trimethyl‐(Z), and hexadecanoic acid‐methyl ester present in yellow bush. Yellow bush (YB) reduced acidic corrosion of API 5 L X65 steel, achieving optimum inhibition efficiency (IE) of 77.53% at 40 ppm, 89.99 at 60 ppm from WL, EIS and Tafel plots.
Joseph Itodo Emmanuel, Fayen Odette Ngasoh, Chidiebele E. J. Uzoagba, Abdulhakeem Bello, Vitalis Chioh Anye, Azikiwe Peter Onwualu, Baboo Yashwansingh Surnam, Okoye Cyril Onyeka   +7 more
wiley   +1 more source

Synthesis and structure of new 4-amino-5-(2-R1-phenyl)-1,2,4-triazole-3-thiol alkilderivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Chemistry of heterocyclic systems is a separate branch of organic chemistry with a long history and future prospects. The ring system of 1,2,4-triazole continuously attracts the interest of chemists, pharmacologists and pharmacists in finding ...
Ye. S. Pruglo
doaj   +1 more source

Some transformations and physicochemical properties of new S-substituted 5-thiophene-(3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Фармацевтичний журнал, 2021
Nitrogen-containing heterocyclic compounds are widely represented in modern organic chemistry. A special place among the huge number of substances presented is occupied by derivatives of 1,2,4-triazole due to their uniqueness and prospects.
A. V. Khilkovets
doaj   +1 more source

Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms [PDF]

, 2010
Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT).
Ola M. Abdallah
core   +1 more source

Electrochemical behaviour of 5-benzyl-4-( 4' -methylphenyl)-4H-1,2,4- triazole-3-thiol by voltammetry

, 2007
The electrochemical study of a thiotriazole compound, 5-benzyl-4-(4'-methylphenyl-4H-1,2,4-triazole-3-thioI (TTA) was made with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using glassy carbon electrode (GCE) as working electrode and an Ag/AgCl reference electrode in the Britton- Robinson buffer.
Dilgin Y., Koparir M., Çetin A., Cansiz A., Yilmaz S., Giray D.   +5 more
openaire   +4 more sources

Precision‐Engineered Poly(GMA‐EGDMA) Microspheres for Multifunctional Applications

Particle &Particle Systems Characterization, Volume 43, Issue 1, January 2026.
The study presents multifunctional poly(GMA‐EGDMA) microspheres designed for advanced separation, catalysis, and biomedical engineering. Through precision synthesis and surface engineering, these microspheres exhibit excellent stability, tunable porosity, and high reactivity.
Imran Ali, Shakeel Ahmad Khan, Mujeeb ur Rahman, Abdul Wasy Zia   +3 more
wiley   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

Novel 1,2,4‐Triazole–Thiopyrimidine Hybrids as COX‐2 Inhibitors: Synthesis, ADME Profiling, Antioxidant Activity, and Molecular Docking

BioMed Research International, Volume 2026, Issue 1, 2026.
This work reports the design, synthesis, and multilevel evaluation of 20 new S‐alkyl derivatives of 6‐(5‐mercapto‐4‐ethyl‐4H‐1,2,4‐triazol‐3‐yl)pyrimidine‐2,4(1H,3H)‐dione as potential selective cyclooxygenase‐2 (COX‐2) inhibitors with antioxidant properties.
Yuriy Karpenko, Volodymyr Parchenko, Olexandr Panasenko, Oleksii Bihdan, Iryna Pukhalska, Oleg Nikiforov, Nataliia Nahorna, Volodymyr Nahornyi, Olena Roik, Poorani Gurumallesh Prabu   +9 more
wiley   +1 more source