1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents [PDF]
Frontiers in Chemistry, 2022 A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial.
Tulika Anthwal, Sumitra Nain
doaj +5 more sources
Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings [PDF]
مجلة بغداد للعلوم, 2013 New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl ...
Baghdad Science Journal
doaj +3 more sources
Antimicrobial Activity of 1,3,4-Thiadiazole Derivatives [PDF]
PharmaceuticalsThe 1,3,4-thiadiazole core has attracted significant attention due to its unique electronic structure, physicochemical properties, and wide-ranging pharmacological potential.
Sebastian Górecki +2 more
doaj +2 more sources
Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review [PDF]
Molecules, 2020 During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-
Sara Janowska +2 more
doaj +3 more sources
New 1,3,4-Thiadiazole Derivatives with Anticancer Activity. [PDF]
Molecules, 2022 We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 breast cancer cells and normal cell line (fibroblasts).
Janowska S +8 more
europepmc +4 more sources
Recent Developments of 1,3,4-Thiadiazole Compounds as Anticancer Agents [PDF]
PharmaceuticalsThe World Health Organization has recently underlined the increasing global burden of cancer, with a particularly alarming impact on underserved populations.
Serena Indelicato +3 more
doaj +2 more sources
Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides [PDF]
Molecules, 2019 New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared 1,3,4-thiadiazole thiol compounds.
Fahad M. Alminderej +4 more
doaj +3 more sources
Theoretical Study of Interaction Between Thiadiazole Derivatives on Fe(110) Surface [PDF]
Journal of Chemistry Letters, 2023 The theoretical performance of 4-methoxyphenyl-1,3,4-thiadiazole (AMPT), 2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole (ACPT) and 2-amino-5-phenyl-1,3,4-thiadiazole (APT) as inhibitors of iron corrosion was assessed with a view of determining the ...
Thomas Nyijime +3 more
doaj +1 more source
Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold
Chemistry, 2022 The chemistry of 1,3,4-thiadiazole is one of the most interesting scaffolds for synthesizing new drug molecules due to their numerous pharmacological activities.
Tulika Anthwal +2 more
doaj +1 more source
A Nano-Mgo and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51) [PDF]
, 2015 In this work, we describe the ‘green’ synthesis of novel 6-(adamantan-1-yl)-2-substitutedimidazo[2,1-b][1,3,4]thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1-yl)-2-bromoethanone and 5-alkyl/aryl-2-amino1,3,4-thiadiazoles on a nano ...
Anusha, S. +13 more
core +8 more sources