Results 51 to 60 of about 8,060 (204)

Aquabis[2,5-bis(pyridin-2-yl)-1,3,4-thiadiazole-κ2N2,N3](trifluoromethanesulfonato-κO)copper(II) trifluoromethanesulfonate

Acta Crystallographica Section E, 2012
2,5-Bis(pyridin-2-yl)-1,3,4-thiadiazole (denoted L) has been found to act as a bidentate ligand in the monomeric title complex, [Cu(CF3O3S)(C12H8N4S)2(H2O)](CF3O3S). The complex shows a distorted octahedrally coordinated copper(II) cation which is linked
Fouad Bentiss, Moha Outirite, Michel Lagrenée, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold [PDF]

, 2016
Free fatty acid receptor 1 (FFA1), previously known as GPR40 is a G protein-coupled receptor and a new target for treatment of type 2 diabetes. Two series of FFA1 agonists utilizing a 1,3,4-thiadiazole-2-caboxamide scaffold were synthetized.
Kovalenko, Alexey, Krasavin, Mikhail, Lukin, Alexey, Moore, Daniel, Tikhonova, Irina G, Zahanich, Ihor, Zhurilo, Nikolay, Zozulya, Sergey   +7 more
core   +1 more source

Toward the 3rd Generation of Smart Farming: Materials, Devices, and Systems for E‐Plant Technologies

Advanced Functional Materials, Volume 36, Issue 3, 8 January 2026.
This review explores the latest developments in e‐plant technologies, which are revolutionizing smart farming by enabling real‐time monitoring of plant and environmental conditions. It covers the design, applications, and systems of e‐plant devices, detailing how they integrate data analytics to optimize agricultural practices, enhance crop yields, and
Daegun Kim, Jonghyun Won, Hyeongmin Park, Jun‐Gyu Choi, Sungjun Park, Giwon Lee   +5 more
wiley   +1 more source

Novel highly emissive non proteinogenic amino acids : synthesis of 1,3,4-thiadiazolyl asparagines and evaluation as fluorimetric chemosensors for biologically relevant transition metal cations [PDF]

, 2011
Highly emissive heterocyclic asparagine derivatives bearing a 1,3,4-thiadiazolyl unit at the side chain, functionalised with electron donor or acceptor groups, were synthesised and evaluated as amino acid based fluorimetric chemosensors for metal cations
A García-Raso, A Torrado, AT Wright, BP Joshi, CIC Esteves, CP Mandl, Cátia I. C. Esteves, DRW Hodgson, F Qu, FM Pfeffer, G Heinrichs, H Ishida, H Kozlowski, H Li, HA Azab, HJ Schneider, J Lin, J Zhao, JJ Gooding, JM Mathews, JV Morris, L-J Fan, M Abo-Ghalia, M Togrul, M. Manuela M. Raposo, MG Holler, MR Heinrich, N Voyer, OA Fedorova, P Kumar, R Martínez-Manêz, RMF Batista, RMF Batista, RMF Batista, RP Cheng, SPG Costa, SPG Costa, SPG Costa, SPG Costa, Susana P. G. Costa, VK Gupta, W Yang, Y Shimazaki, Y Zheng, Z Xu   +44 more
core   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Recent developments in the chemistry and enzyme inhibitory activity of fused thiazoles and thiadiazoles

Vietnam Journal of Chemistry, Volume 63, Issue 6, Page 872-882, December 2025.
Abstract The combination of cyclization reactions of thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling reactions provided a convenient synthesis of annulated, fluorinated and non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐ones, benzothiazolo[3,2‐a]pyridimidin‐4‐ones, benzothiazolo[2,3‐b]quinazolin‐12‐ones and ...
Peter Langer
wiley   +1 more source

Synthesis and Anti-inflammatory Activity of Some New 6-Aryltriazolo[3,4-b][1,3,4]thiadiazole Derivatives

Журнал органічної та фармацевтичної хімії
A series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats.
Iryna I. Myrko
doaj   +1 more source

Inhibition effect of 2-amino-5-ethyl-1, 3, 4-thiadiazole on corrosion behaviour of austenitic stainless steel type 304 in dilute HCl solution [PDF]

, 2016
The corrosion inhibition of type 304 austenitic stainless steel by 2-amino-5-ethyl-1, 3, 4-thiadiazole (TTD) compound and the electrochemical behaviour in dilute HCl solution were investigated through potentiodynamic polarization test, mass loss ...
Fedotova, T., Loto, C. A., Loto, R. T., Popoola, A. P. I.   +3 more
core   +1 more source

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, Volume 14, Issue 11, November 2025.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source