Results 81 to 90 of about 2,516,936 (145)

18β-Glycyrrhetinic Acid Derivatives Possessing a Trihydroxylated A Ring Are Potent Gram-Positive Antibacterial Agents

, 2016
The oleanane-type triterpene 18β-glycyrrhetinic acid (1) was modified chemically through the introduction of a trihydroxylated A ring and an ester moiety at C-20 to enhance its antibacterial activity.
Dao-Ping Wang (2521132), Xiao-Sheng Yang (2441740), Li-Rong Huang (2521126), Heng Luo (225807), Jian-Xin Zhang (397211), Xiao-Jiang Hao (693964), Qi-Ji Li (2521129)   +6 more
core   +1 more source

18β-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures

, 2011
To investigate on the possible protective activity of glycyrrhizin (GL), 18β-glycyrrhetinic acid (18β-GA) and glabridin (GLB) against UVB radiation damage in human keratinocyte cultures the following assays were performed: MTT, Comet, ROS generation and ...
ROSSI, Tiziana, GIANNETTI, Alberto, Morini D, VERATTI, Eugenia, GIUDICE, Stefania, MAGNONI, Cristina, AZZONI, Paola, Bruni E, BENASSI, Luisa, BERTAZZONI, Giorgia   +9 more
core  

Inhibition of Rat Acute Inflammatory Paw Oedema by Dihemiphthalate of Glycyrrhetinic Acid Derivatives: Comparison with Glycyrrhetinic Acid

, 1993
The anti-inflammatory profile of dihemiphthalate compounds of glycyrrhetinic acid derivatives in acute rat paw oedema induced by various vasoactive agents was compared with the parent compound.
Kazuko Inoue, Tadao Takeuchi, Nobuyuki Nagata, Shoji Shibata, Hideo Inoue   +4 more
core   +1 more source

Induction of inducible nitric oxide synthase expression by 18β-glycyrrhetinic acid in macrophages [PDF]

, 2002
Glycyrrhizin (GL), a triterpenoid saponin fraction of licorice, is reported to have anti-viral and anti-tumor activities and is metabolized to 18β-glycyrrhetinic acid (GA) in the intestine by intestinal bacteria.
Jeong, Hye Gwang, Hye Gwang Jeong, Kim, Ji Young, Ji Young Kim   +3 more
core   +1 more source

Antimicrobial and Antioxidant Activities of 18β-Glycyrrhetinic Acid Biotransformed by Aspergillus niger

Microbiology Research
The search for novel plant-based antioxidant and antibacterial medication has garnered a lot of attention lately. Glycyrrhiza glabra, known as licorice, is one of the most important medicinal plants.
Shaymaa Wagdy El-Far, Mahmoud A. Al-Saman, Fatma I. Abou-Elazm, Rania Ibrahim Shebl, Asmaa Abdella   +4 more
doaj   +1 more source

Scalable microfluidic fabrication of optimized phospholipid nanocarriers for enhanced topical bioavailability: Analytical QbD integration and ex vivo skin permeation assessment

International Journal of Pharmaceutics: X
18β-Glycyrrhetinic acid (18β-GA), the primary bioactive metabolite of glycyrrhizin (GL) derived from licorice root, exhibits anti-inflammatory, antioxidant, and antimicrobial activities, as well as excellent biocompatibility, making it a promising ...
Giulia Bucciarelli, Giulia Curzi, Mattia Tiboni, Annalisa Aluigi, Andrea Heinz, Luca Casettari   +5 more
doaj   +1 more source

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Drug Design, Development and Therapy
Yanmin Pei,1,* Meidong Si,1,* Xuemei Ma,1 Siyun Liu,1 Fang Zhao,2 Ru Zhou1,3,4 1School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2Pediatric Intensive Care Unit, General Hospital of Ningxia ...
Pei Y, Si M, Ma X, Liu S, Zhao F, Zhou R
doaj  

Inhibitory Effect of Glycyrrhetinic Acid Derivatives on Arachidonic Acid-induced Mouse Ear Oedema

, 1988
The inhibitory effects of glycyrrhetinic acid and its derivatives were examined on arachidonic acid (AA)-induced ear oedema in mice. Of the compounds, dihemiphthalate derivatives of 18β-olean-12-ene-3β, 30-diol (IId, IId′), 18β-olean-9(11)12-diene-3β, 30-
Yasuko Koshihara, Takeo Mori, Shoji Shibata, Hideo Inoue   +3 more
core   +1 more source

Derivatization, molecular docking and in vitro acetylcholinesterase inhibitory activity of glycyrrhizin as a selective anti-Alzheimer agent

, 2018
Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action of acetylcholine (ACh); thus, alleviate symptoms of Alzheimer’s disease (AD). Glycyrrhizin, is the main active compound in liquorice root.
Fardous F. El-Senduny (5103623), Diaaeldin M. Elimam (5103626), Amira S. Mira (5103620), Farid A. Badria (448269), Fatma M. Abdel Bar (7390310)   +4 more
core   +1 more source

versatility of 18β-glycyrrhetinic acid in attenuating pulmonary inflammatory disorders

EXCLI Journal : Experimental and Clinical Sciences, 2023
Mohamad Siddiq Bin Mohamad, Ruby-Jean Reyes, Gabriele De Rubis, Keshav Raj Paudel, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan   +6 more
doaj   +1 more source