Results 61 to 70 of about 1,245 (119)

Scalable microfluidic fabrication of optimized phospholipid nanocarriers for enhanced topical bioavailability: Analytical QbD integration and ex vivo skin permeation assessment

International Journal of Pharmaceutics: X
18β-Glycyrrhetinic acid (18β-GA), the primary bioactive metabolite of glycyrrhizin (GL) derived from licorice root, exhibits anti-inflammatory, antioxidant, and antimicrobial activities, as well as excellent biocompatibility, making it a promising ...
Giulia Bucciarelli, Giulia Curzi, Mattia Tiboni, Annalisa Aluigi, Andrea Heinz, Luca Casettari   +5 more
doaj   +1 more source

Effects of 18β-Glycyrrhetinic Acid on Fungal Protease-Induced Airway Inflammatory Responses

Mediators of Inflammation, 2018
Airway epithelial cells secrete diverse inflammatory mediators in response to various stimuli. Thus, early regulation of immune responses in the airway epithelium is likely critical for the control of chronic inflammatory diseases.
Yun Hee Kim, Dong Eon Kim, Seung-Hyo Lee
doaj   +1 more source

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Drug Design, Development and Therapy
Yanmin Pei,1,* Meidong Si,1,* Xuemei Ma,1 Siyun Liu,1 Fang Zhao,2 Ru Zhou1,3,4 1School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2Pediatric Intensive Care Unit, General Hospital of Ningxia ...
Pei Y, Si M, Ma X, Liu S, Zhao F, Zhou R
doaj  

versatility of 18β-glycyrrhetinic acid in attenuating pulmonary inflammatory disorders

EXCLI Journal : Experimental and Clinical Sciences, 2023
Mohamad Siddiq Bin Mohamad, Ruby-Jean Reyes, Gabriele De Rubis, Keshav Raj Paudel, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan   +6 more
doaj   +1 more source

The protective effects of 18β-glycyrrhetinic acid against inflammation microenvironment in gastric tumorigenesis targeting PGE2-EP2 receptor-mediated arachidonic acid pathway

International Journal of Immunopathology and Pharmacology, 2018
Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for gastrointestinal diseases. Glycyrrhiza glabra , a traditional Chinese medicine, has been shown to safely suppress gastric cancer; however, the anti-
Donghui Cao, Jing Jiang, Dan Zhao, Menghui Wu, Houjun Zhang, Tianyu Zhou, Tetsuya Tsukamoto, Masanobu Oshima, Quan Wang, Xueyuan Cao   +9 more
doaj   +1 more source

Rapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors

Microbiology Spectrum
STW 5, a blend of nine medicinal plant extracts, exhibits promising efficacy in treating functional gastrointestinal disorders, notably irritable bowel syndrome (IBS). Nonetheless, its effects on the gastrointestinal microbiome and the role of microbiota
Timo A. Thumann, Eva-Maria Pferschy-Wenzig, Christina Kumpitsch, Stefanie Duller, Christoph Högenauer, Patrizia Kump, Heba Aziz-Kalbhenn, Ramy M. Ammar, Sabine Rabini, Christine Moissl-Eichinger, Rudolf Bauer   +10 more
doaj   +1 more source

Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine. [PDF]

Front Immunol, 2023
Khalil H, Nada AH, Mahrous H, Hassan A, Rijo P, Ibrahim IA, Mohamed DD, Al-Salmi FA, Mohamed DD, Elmaksoud AIA.   +9 more
europepmc   +1 more source

Omega-3 polyunsaturated fatty acids are associated with microbiota-related 18β-glycyrrhetinic acid alterations and M2 macrophage polarization in type 1 diabetes mellitus

Frontiers in Pharmacology
IntroductionOmega-3 polyunsaturated fatty acids (PUFAs) have been widely reported to exert beneficial effects in type 1 diabetes mellitus (T1DM). However, the mechanisms by which Omega-3 PUFAs influence pancreatic islet function through the gut-islet ...
Yifan Guo, Fang Hu, Allan Zijian Zhao, Yingjuan Zeng, Haoying Chen, Ai Wang, Xiaoxi Li, Li Cong   +7 more
doaj   +1 more source

18β-glycyrrhetinic Acid Modulated Autophagy is Cytotoxic to Breast Cancer Cells. [PDF]

Int J Med Sci, 2023
Hsu YC, Hsieh WC, Chen SH, Li YZ, Liao HF, Lin MY, Sheu SM.   +6 more
europepmc   +1 more source

Inactivation of EGFR/ERK/NF-κB signalling associates with radiosensitizing effect of 18β-glycyrrhetinic acid on progression of hepatocellular carcinoma. [PDF]

J Cell Mol Med, 2023
Liu YC, Lin CH, Chen KT, Lai DW, Hsu FT.
europepmc   +1 more source