Results 51 to 60 of about 2,516,936 (145)

Herbal Formula AC591 Protects Against Cisplatin‐Induced Hearing Loss by Inhibiting p53‐Mediated Ferroptosis

Smart Medicine, Volume 5, Issue 5, October 2026.
AC591 and its core active component 18β‐glycyrrhetinic acid effectively alleviate cisplatin‐induced ototoxicity by binding p53 and suppressing p53‐mediated ferroptosis, representing promising agents for preventing cisplatin‐related hearing loss. ABSTRACT Cisplatin is a widely utilized chemotherapeutic agent for the treatment of malignant cancers ...
Yunhao Wu, Yu Tao, Lin Wei, Qiuping Liu, Jiaxin Liu, Wen Jiang, Weiwei Shi, Peng Cao, Xiaolong Fu, Cheng Cheng   +9 more
wiley   +1 more source

Contrasting Coastal Environments Are Associated With Ecotype‐Specific Leaf Polyphenolic Profiles and Bioactivity in Corema album subsp. album

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Leaves of two Corema album subsp. album ecotypes from two contrasting coastal microclimates were analysed using mineral profiling, (poly)phenolic assays, and LC–MS metabolomics. Ecotype‐specific metabolic strategies were revealed, linking environmental stress to antioxidant and cytotoxic activities.
Eliana Fernandes, Riccardo Trentin, Maria João Rodrigues, Luísa Custódio   +3 more
wiley   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways

Frontiers in Pharmacology, 2018
Bone metabolism is determined by a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts. The imbalance due to over-activated osteoclasts plays an important role in various diseases.
Xiao Chen, Xiao Chen, Xin Zhi, Xin Zhi, Zhifeng Yin, Xiaoqun Li, Longjuan Qin, Zili Qiu, Jiacan Su, Jiacan Su   +9 more
doaj   +1 more source

18β-glycyrrhetinic acid accelerates liver regeneration after partial hepatectomy in mice

Medicine in Drug Discovery
Objective: 18β-Glycyrrhetinic acid (18β-GA), a key bioactive triterpenoid in Glycyrrhiza uralensis Fisch, is recognized for its hepatoprotective effects in liver injury.
Yuan Li, Yanxin Zhang, Guanqun Wan, Shaofei Song, Tingting Zhao, Renjie Cao, Weiwei Zeng, Min Huang, Yiming Jiang   +8 more
doaj   +1 more source

Encounters With Traditional Medicine and Further Multidisciplinary and International Cooperation

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
ABSTRACT Background The integration of traditional medicine (TM) into modern healthcare has gained global momentum. Following the inclusion of TM in the 11th revision of the International Classification of Diseases, multidisciplinary and international cooperation has become increasingly essential.
Kokoro Ichihara, Ryota Sakoda, Yuto Matsuura, Hong‐Wook Choi, Toshiaki Makino, Tomoko Suzuki, Shin Takayama   +6 more
wiley   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, Volume 13, Issue 39, 13 July 2026.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Synthesis and evaluation of triazole linked glycosylated 18β-glycyrrhetinic acid derivatives as anticancer agents

, 2014
A series of glycosyl triazol linked 18β-glycyrrhetinic acid (GA) derivatives have been synthesized using 1,3-dipolar cycloaddition reaction of per-O-acetylated glycosyl azide derivatives (4a-h) with propargyl ester of 18β-glycyrrhetinic acid (GA) (2 and ...
Biswas, Kaushik, Parida, Pravat Kumar*, Jana, Kuladip, Raha, Sanghamitra, Ghosh, Tamashree, Sau, Abhijit*, Misra, Anup Kumar   +6 more
core   +1 more source

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

Cancer Science, Volume 117, Issue 7, Page 1778-1794, July 2026.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang, Shiji Zeng, Dingye Wang, Junbo Jiang, Zhenzhen Li, Jingbi Li, Dan Chen, Xu Zhao, Zheng Ying, Yuehua Deng, Qianwei Cai, Silin Mai, Jiayi Zheng, Qiaohong Yang, Fang Liu, Biaoyan Du, Jianyong Xiao, Xiaoyi Liu, Kun Wang   +18 more
wiley   +1 more source

Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species

Journal of Advanced Research, 2015
Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and as sweetener in the food industry.
Mohamed A. Farag, Andrea Porzel, Ludger A. Wessjohann   +2 more
doaj   +1 more source