Results 51 to 60 of about 1,245 (119)

Synthesis of glycyrrhetinic acid-modified liposomes to deliver Murrayafoline A for treatment of hepatocellular carcinoma

Journal of Materials Science: Materials in Medicine, 2022
Hepatocellular carcinoma is a common type of cancer associated with a high mortality rate. Among several bioactive compounds, Murrayafoline A (MuA) has been proved as a bio substance that exhibits great potentials in treating liver cancer.
Cuc Thi Dinh, Ha Thi Vu, Quynh Thi Huong Phan, Linh Phuong Nguyen, Toan Quoc Tran, Dung Van Tran, Nguyen Ngoc Quy, Dung Thuy Nguyen Pham, Duong Thanh Nguyen   +8 more
doaj   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, Volume 2, Issue 3, Page 103-119, September 2025.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Soft Nanocarriers as Antimicrobial Co‐Delivery Systems to Combat Resistant Infections

Advanced Healthcare Materials, Volume 14, Issue 21, August 19, 2025.
Soft nanocarrier‐based co‐delivery systems present a versatile and promising platform for combating antimicrobial resistance (AMR) by enabling spatiotemporally controlled, pathogen‐specific drug release. Their tunable physicochemical properties allow for the co‐encapsulation of synergistic antimicrobial agents, optimization of drug ratios, and surface ...
Anamarija Nikoletic, Evangelos Natsaridis, Timon Flathmann, Daiane P. C. Quadros, Nubia Gogniat, Oya Tagit   +5 more
wiley   +1 more source

Exploring New Structural Features of the 18β-Glycyrrhetinic Acid Scaffold for the Inhibition of Anaplastic Lymphoma Kinase

Molecules, 2019
Novel 18β-glycyrrhetinic acid derivatives possessing a carbamate moiety and structurally similar ester derivatives were developed and evaluated for their efficacy as antitumor inhibitors.
Dong Cai, ZhiHua Zhang, Yu Chen, YanYan Zhang, YuQi Sun, YiXia Gong   +5 more
doaj   +1 more source

Connexin 43 Role in Mitochondrial Transfer and Homeostasis in the Central Nervous System

Journal of Cellular Physiology, Volume 240, Issue 8, August 2025.
ABSTRACT Connexin 43 (Cx43) is a transmembrane protein involved in the assembly of gap junctions (GJs) and hemichannels (HCs), organized structures that allow the transferring of ions and small signaling molecules between cells and/or extracellular environment, thereby contributing to tissue homeostasis intercellular communication.
Anna Gervasi, Simona D'Aprile, Simona Denaro, Maria Angela Amorini, Nunzio Vicario, Rosalba Parenti   +5 more
wiley   +1 more source

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR

Molecules, 2014
Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides is reported.
Yong-An Yang, Wen-Jian Tang, Xin Zhang, Ji-Wen Yuan, Xin-Hua Liu, Hai-Liang Zhu   +5 more
doaj   +1 more source

Biocomputational Prediction of Anticancer Activity of Ayurvedic Plants Inhibiting Cyclin D1: Molecular Docking Study of the Major Active Compounds of Licorice Root Extract (Glycyrrhiza glabra) in Inhibiting Oral Squamous Cell Carcinoma Proliferation

Indonesian Journal of Cancer
Background: Oral squamous cell carcinoma (OSCC) reported for > 90% of oral cancer cases, causing 377,713 new cases and 177,757 deaths in 2020. Treatments like surgery, chemotherapy, and radiotherapy affect patients’ lives. This study focuses on Licorice (
Mohammad Iqbal
doaj   +1 more source

Charge-transfer interaction mediated organogels from 18β-glycyrrhetinic acid appended pyrene

Beilstein Journal of Organic Chemistry, 2013
We describe herein the two-component charge-transfer (CT) interaction induced organogel formation with 18β-glycyrrhetinic acid appended pyrene (GA-pyrene, 3) as the donor, and 2,4,7-trinitrofluorenone (TNF, 4) as the acceptor.
Jun Hu, Jindan Wu, Qian Wang, Yong Ju
doaj   +1 more source

Antimicrobial and Antioxidant Activities of 18β-Glycyrrhetinic Acid Biotransformed by Aspergillus niger

Microbiology Research
The search for novel plant-based antioxidant and antibacterial medication has garnered a lot of attention lately. Glycyrrhiza glabra, known as licorice, is one of the most important medicinal plants.
Shaymaa Wagdy El-Far, Mahmoud A. Al-Saman, Fatma I. Abou-Elazm, Rania Ibrahim Shebl, Asmaa Abdella   +4 more
doaj   +1 more source