Results 31 to 40 of about 2,516,936 (145)

18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity

, 2021
18β-glycyrrhetinic acid; 3T3-L1; Cannabinoid receptor type 1; Licorice ...
임경민, 하헌주
core   +1 more source

Bioactive microbial metabolites from glycyrrhetinic acid

, 2009
Biotransformation of 18β-glycyrrhetinic acid, using Absidia pseudocylinderospora ATCC 24169, Gliocladium viride ATCC 10097 and Cunninghamella echinulata ATCC 8688a afforded seven metabolites, which were identified by different spectroscopic techniques ...
Maatooq, Galal T., Rosazza, John P., Gray, A.I., Marzouk, Amani M.   +3 more
core   +4 more sources

Transcriptional profile changes after treatment of ischemia reperfusion injury-induced kidney fibrosis with 18β-glycyrrhetinic acid. [PDF]

Ren Fail, 2022
Chronic kidney disease (CKD) is characterized by renal fibrosis without effective therapy. 18β-Glycyrrhetinic acid (GA) is reported to have detoxification and anti-inflammatory functions and promotes tissue repair.
Jiang Y, Cai C, Zhang P, Luo Y, Guo J, Li J, Rong R, Zhang Y, Zhu T.   +8 more
europepmc   +2 more sources

Physiology-Based Pharmacokinetic Study on 18β-Glycyrrhetic Acid Mono-Glucuronide (GAMG) Prior to Glycyrrhizin in Rats

Molecules, 2022
To understand that 18β-Glycyrrhetic acid 3-O-mono-β-D-glucuronide (GAMG) showed better pharmacological activity and drug-like properties than 18β-Glycyrrhizin (GL); a rapid and sensitive HPLC-MS/MS method was established for the simultaneous ...
Mengxin Cao, Jiawei Zuo, Jian-Guo Yang, Chenyao Wu, Yongan Yang, Wenjian Tang, Lili Zhu   +6 more
doaj   +1 more source

Enhancing Cardioprotection Through Neutrophil-Mediated Delivery of 18β-Glycyrrhetinic Acid in Myocardial Ischemia/Reperfusion Injury. [PDF]

Adv Sci (Weinh)
Myocardial ischemia/reperfusion injury (MI/RI) generates reactive oxygen species (ROS) and initiates inflammatory responses. Traditional therapies targeting specific cytokines or ROS often prove inadequate.
Han D, Wang F, Jiang Q, Qiao Z, Zhuang Y, An Q, Li Y, Tang Y, Li C, Shen D, Shen D.   +10 more
europepmc   +2 more sources

18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling

Chinese Journal of Physiology, 2022
Endoplasmic reticulum stress (ERS)-induced inflammation participates in the occurrence of pulmonary arterial hypertension (PAH) by promoting pulmonary vascular remodeling, which involved in the activation of PERK/eIF2α/NF-κB signaling pathway.
Jia-Ling Wang, Hui Liu, Zhi-Cheng Jing, Fang Zhao, Ru Zhou   +4 more
doaj   +1 more source

18β-Glycyrrhetinic Acid Induces Metabolic Changes and Reduces <i>Staphylococcus aureus</i> Bacterial Cell-to-Cell Interactions. [PDF]

Antibiotics (Basel), 2022
The rise in bacterial resistance to common antibiotics has raised an increased need for alternative treatment strategies. The natural antibacterial product, 18β-glycyrrhetinic acid (GRA) has shown efficacy against community-associated methicillin ...
Weaver AJ, Borgogna TR, O'Shea-Stone G, Peters TR, Copié V, Voyich J, Teintze M.   +6 more
europepmc   +2 more sources

Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis

Frontiers in Pharmacology, 2021
18β-Glycyrrhetinic acid (18β-GA), an active component from Glycyrrhiza glabra L. root (licorice), has been demonstrated to be able to protect against inflammatory response and reduce methotrexate (MTX)-derived toxicity.
Yunhui Feng, Liyan Mei, Maojie Wang, Maojie Wang, Qingchun Huang, Runyue Huang, Runyue Huang, Runyue Huang, Runyue Huang   +8 more
doaj   +1 more source

Synthesis and biological activity of new 18β-glycyrrhetinic acid derivatives [PDF]

, 2016
In an attempt to find out new, potent and safe anti-inflammatory molecules and as a contribution in the chemistry of triterpenes, a series of 18β-glycyrrhetinic acid (GTA) derivatives (4a–j, 5a–e, 7–9, 11–13) were synthesized and evaluated as anti ...
Ismail, Mohamed A.H., El-Mekkawy, Sahar, Hanna, Atef G., Ismail, Nasser S.M., Radwan, Mohamed O.   +4 more
core   +1 more source

Analysis of glycyrrhizin binding to protein HMGB1

Medicine in Drug Discovery, 2020
Glycyrrhizin (GLR) is triterpenoid saponin used for the treatment of various of liver and skin diseases. GLR blocks the nucleocytoplasmic translocation of the protein HMGB1, thereby inhibiting its extracellular release and its functions as a damage ...
Gérard Vergoten, Christian Bailly
doaj   +1 more source