Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential [PDF]
Plants, 2023 Glycyrrhiza glabra L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy in treating several ailments.
Pottathil Shinu +11 more
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Antibacterial activity of 18β-glycyrrhetinic acid against Neisseria gonorrhoeae in vitro [PDF]
Biochemistry and Biophysics Reports, 2023 Gonorrhea is the second most common sexually transmitted diseases worldwide. Chronic infection of Neisseria gonorrhoeae (N. gonorrhoeae) can lead to severe complications. Presently, N.
Yuanyuan Zhao, Xiaohong Su
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Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid [PDF]
Molecules, 2023 Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging. Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were ...
Weiyan Quan +8 more
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Study on the mechanism of 18β-glycyrrhetinic acid inhibiting the proliferation of renal cancer cells by inducing autophagy through the miR-27a-5p/LC3 axis [PDF]
Frontiers in OncologyBackgroundRenal carcinoma is a common, aggressive urinary tract malignancy with notable clinical challenges such as severe treatment toxicity and poor patient outcomes; 18β-glycyrrhetinic acid (18β-GA), an active component of Chinese herb Glycyrrhiza ...
Shumin Jia +9 more
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Pharmaceutical Biology, 2021 Context 18β-Glycyrrhetinic acid (18β-GA), a pentacyclic triterpenoid saponin metabolite of glycyrrhizin, exhibits several biological activities. Objective We investigated the effects of 18β-GA on MA104 cells infected with rotavirus (RV) and its potential
Xiaoyan Wang +5 more
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18β-Glycyrrhetinic acid inhibits the proliferation and metastasis of gastric cancer by inhibiting the TCTP/AKT/P53 signaling pathway [PDF]
Scientific Reports18β-Glycyrrhetinic acid (18β-GA) has a therapeutic effect on gastric cancer (GC), but its mechanism of action is still unclear. We analyzed the effects of 18β-GA on the proliferation, migration and invasion of GC cells using CCK technology, colony ...
Jun-Fei Zhang +8 more
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Mechanistic insights into 18β-glycyrrhetinic acid-induced apoptosis in SCC-9 cells revealed by TMT proteomics and network pharmacology [PDF]
Scientific Reports18β-Glycyrrhetinic acid (18β-GRA), a major bioactive component of licorice, exhibits recognized biological activities in various tumor models. However, its cellular effects and underlying molecular mechanisms in tongue squamous cell carcinoma (TSCC) are ...
Hongli Fan, Daichang Yuan, Yi Nan
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Impact of C18 Epimerization of Indole- and Pyrazole-Fused 18β-Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies. [PDF]
ChemMedChemThe indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
De-la-Cruz-Martínez L +10 more
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Effects of Silver Nanoparticle-Loaded 18β-Glycyrrhetinic Acid on P2X7 Receptor and Endoplasmic Reticulum Stress-Mediated NLRP3 Inflammasome Activation in Testicular Tissue in an Animal Diabetes Model. [PDF]
Food Sci NutrEffects of silver nanoparticle‐loaded 18β‐glycyrrhetinic acid on P2X7 receptor and endoplasmic reticulum stress‐mediated NLRP3 inflammasome activation in testicular tissue in an experimental diabetes model in rats. ABSTRACT Diabetes, a metabolic disease characterized by high blood sugar, causes damage to many organs in the body.
Gelen V +5 more
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Journal of Integrative Agriculture, 2023 Natural products have long been a crucial source of, or provided inspiration for new agrochemical discovery. Naturally occurring 18β-glycyrrhetinic acid shows broad-spectrum bioactivities and is a potential skeleton for novel drug discovery.
Ying-lian SONG +9 more
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