18β-Glycyrrhetinic acid inhibits the proliferation and metastasis of gastric cancer by inhibiting the TCTP/AKT/P53 signaling pathway [PDF]
Scientific Reports18β-Glycyrrhetinic acid (18β-GA) has a therapeutic effect on gastric cancer (GC), but its mechanism of action is still unclear. We analyzed the effects of 18β-GA on the proliferation, migration and invasion of GC cells using CCK technology, colony ...
Jun-Fei Zhang +8 more
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Mechanistic insights into 18β-glycyrrhetinic acid-induced apoptosis in SCC-9 cells revealed by TMT proteomics and network pharmacology [PDF]
Scientific Reports18β-Glycyrrhetinic acid (18β-GRA), a major bioactive component of licorice, exhibits recognized biological activities in various tumor models. However, its cellular effects and underlying molecular mechanisms in tongue squamous cell carcinoma (TSCC) are ...
Hongli Fan, Daichang Yuan, Yi Nan
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18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. [PDF]
PLoS ONE, 2017 Licorice (Glycyrrhiza) species have been widely used as a traditional medicine and a natural sweetener in foods. The 18β-glycyrrhetinic acid (18β-GA) is a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti ...
Chi-Feng Hung +7 more
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Glycyrrhetinic acid and its derivatives in infectious diseases
Current Issues in Pharmacy and Medical Sciences, 2016 Introduction. Licorice or liquorice (Glycyrrhiza glabra, Leguminosae) is a perennial plant naturally occurring or cultivated in Europe and Asia. It was appreciated by many ancient cultures, and was employed within Arabic medicine and (beginning in the ...
Langer Dominik +2 more
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Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats [PDF]
Frontiers in Pharmacology, 2019 Pulmonary arterial hypertension (PAH) is a destructive and rare disorder characterized by a progressive increase in pulmonary artery pressure and vasoconstriction, ultimately leading to right ventricular failure and death. 18β-Glycyrrhetinic acid (18β-GA)
Min Zhang +15 more
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Omega-3 polyunsaturated fatty acids are associated with microbiota-related 18β-glycyrrhetinic acid alterations and M2 macrophage polarization in type 1 diabetes mellitus [PDF]
Frontiers in PharmacologyIntroductionOmega-3 polyunsaturated fatty acids (PUFAs) have been widely reported to exert beneficial effects in type 1 diabetes mellitus (T1DM). However, the mechanisms by which Omega-3 PUFAs influence pancreatic islet function through the gut-islet ...
Yifan Guo +7 more
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Charge-transfer interaction mediated organogels from 18β-glycyrrhetinic acid appended pyrene
Beilstein Journal of Organic Chemistry, 2013 We describe herein the two-component charge-transfer (CT) interaction induced organogel formation with 18β-glycyrrhetinic acid appended pyrene (GA-pyrene, 3) as the donor, and 2,4,7-trinitrofluorenone (TNF, 4) as the acceptor.
Jun Hu, Jindan Wu, Qian Wang, Yong Ju
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International Journal of Immunopathology and Pharmacology, 2018 Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for gastrointestinal diseases. Glycyrrhiza glabra , a traditional Chinese medicine, has been shown to safely suppress gastric cancer; however, the anti-
Donghui Cao +9 more
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Biochemistry and Biophysics Reports, 2021 The acute liver disease is involved in aberrant release of high-mobility group box 1 (HMGB1). Glycyrrhizin (GL), a traditional Chinese medicine for liver disease, binds to HMGB1, thereby inhibits tissue injury.
Akihiro Morita +7 more
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Haematologica, 2022 Primary immune thrombocytopenia (ITP) is the most common acquired autoimmune bleeding disorder. Abnormally increased levels of High Mobility Group Box 1 (HMGB1) protein associate with thrombocytopenia and therapeutic outcome in ITP.
Haoyi Wang +14 more
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