Results 21 to 30 of about 1,247 (117)

Glycyrrhizin and its derivatives promote hepatic differentiation via sweet receptor, Wnt, and Notch signaling

Biochemistry and Biophysics Reports, 2021
The acute liver disease is involved in aberrant release of high-mobility group box 1 (HMGB1). Glycyrrhizin (GL), a traditional Chinese medicine for liver disease, binds to HMGB1, thereby inhibits tissue injury.
Akihiro Morita, Yuta Omoya, Rie Ito, Yuya Ishibashi, Keiichi Hiramoto, Shiho Ohnishi, Nobuji Yoshikawa, Shosuke Kawanishi   +7 more
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18β-glycyrrhetinic acid attenuates global cerebral ischemia/reperfusion-induced cardiac damage in C57BL/J6 mice

Brazilian Journal of Pharmaceutical Sciences, 2023
The aim of the present study is to investigate the cardioprotective effects of 18β-glycyrrhetinic acid (18β -GA) against oxidative and histological damage caused by global cerebral ischemia/ reperfusion (I/R) in C57BL/J6 mice.
Neşe Başak Türkmen, Hande Yüce, Aslı Taşlıdere, Yasemin Şahin, İdris Ayhan, Songül UNÜVAR, Osman Çiftçi   +6 more
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Enhancing regulatory T-cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia

Haematologica, 2022
Primary immune thrombocytopenia (ITP) is the most common acquired autoimmune bleeding disorder. Abnormally increased levels of High Mobility Group Box 1 (HMGB1) protein associate with thrombocytopenia and therapeutic outcome in ITP.
Haoyi Wang, Tianshu Yu, Ning An, Yunqi Sun, Pengcheng Xu, Panpan Han, Yajing Zhao, Lingjun Wang, Xiaofei Ni, Yubin Li, Guosheng Li, Yanfeng Liu, Jun Peng, Ming Hou, Yu Hou   +14 more
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18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. [PDF]

PLoS ONE, 2017
Licorice (Glycyrrhiza) species have been widely used as a traditional medicine and a natural sweetener in foods. The 18β-glycyrrhetinic acid (18β-GA) is a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti ...
Chi-Feng Hung, Chien-Yu Hsiao, Wen-Hao Hsieh, Hsin-Ju Li, Yi-Ju Tsai, Chun-Nan Lin, Hsun-Hsien Chang, Nan-Lin Wu   +7 more
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18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling

Chinese Journal of Physiology, 2022
Endoplasmic reticulum stress (ERS)-induced inflammation participates in the occurrence of pulmonary arterial hypertension (PAH) by promoting pulmonary vascular remodeling, which involved in the activation of PERK/eIF2α/NF-κB signaling pathway.
Jia-Ling Wang, Hui Liu, Zhi-Cheng Jing, Fang Zhao, Ru Zhou   +4 more
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Physiology-Based Pharmacokinetic Study on 18β-Glycyrrhetic Acid Mono-Glucuronide (GAMG) Prior to Glycyrrhizin in Rats

Molecules, 2022
To understand that 18β-Glycyrrhetic acid 3-O-mono-β-D-glucuronide (GAMG) showed better pharmacological activity and drug-like properties than 18β-Glycyrrhizin (GL); a rapid and sensitive HPLC-MS/MS method was established for the simultaneous ...
Mengxin Cao, Jiawei Zuo, Jian-Guo Yang, Chenyao Wu, Yongan Yang, Wenjian Tang, Lili Zhu   +6 more
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Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug

The Scientific World Journal, 2013
The triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis.
Fengbo Wu, Ting Xu, Chi Liu, Can Chen, Xiangrong Song, Yu Zheng, Gu He   +6 more
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18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer.

PLoS ONE, 2014
18β-Glycyrrhetinic acid (18β-GA) is a bioactive component of licorice. The anti-cancer activity of 18β-GA has been studied in many cancer types, whereas its effects in lung cancer remain largely unknown. We first showed that 18β-GA effectively suppressed
Run-Yue Huang, Yong-Liang Chu, Qing-Chun Huang, Xiu-Min Chen, Ze-Bo Jiang, Xian Zhang, Xing Zeng   +6 more
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Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis

Frontiers in Pharmacology, 2021
18β-Glycyrrhetinic acid (18β-GA), an active component from Glycyrrhiza glabra L. root (licorice), has been demonstrated to be able to protect against inflammatory response and reduce methotrexate (MTX)-derived toxicity.
Yunhui Feng, Liyan Mei, Maojie Wang, Maojie Wang, Qingchun Huang, Runyue Huang, Runyue Huang, Runyue Huang, Runyue Huang   +8 more
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Analysis of glycyrrhizin binding to protein HMGB1

Medicine in Drug Discovery, 2020
Glycyrrhizin (GLR) is triterpenoid saponin used for the treatment of various of liver and skin diseases. GLR blocks the nucleocytoplasmic translocation of the protein HMGB1, thereby inhibiting its extracellular release and its functions as a damage ...
Gérard Vergoten, Christian Bailly
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