Results 41 to 50 of about 1,245 (119)

Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200 
Amal Elrherabi   +8 more
wiley   +1 more source

Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

open access: yesFrontiers in Pharmacology, 2019
Pulmonary arterial hypertension (PAH) is a destructive and rare disorder characterized by a progressive increase in pulmonary artery pressure and vasoconstriction, ultimately leading to right ventricular failure and death. 18β-Glycyrrhetinic acid (18β-GA)
Min Zhang   +15 more
doaj   +1 more source

Lueyang Black‐Boned Chicken and Black Bean Soup Promoting the Acute Healing of Skin Wounds, Accompanying Special Flavor Substances

open access: yesFood Chemistry International, Volume 2, Issue 1, Page 46-57, March 2026.
ABSTRACT Animal protein and plant protein make the protein supplement more comprehensive and further optimize the nutritional structure of the national diet. In this study, a “dual protein” Lueyang black‐boned chicken and black bean soup (FS) was prepared.
Mengya Zhao   +6 more
wiley   +1 more source

Novel Glycyrrhizinic Acid Derivative YCY‐20 Inhibits Cerebral Ischemia/Reperfusion Induced Apoptosis via the AGE‐RAGE/MAPK Pathway

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Novel licorice‐derived compound YCY‐20 attenuates cerebral ischemia–reperfusion injury by suppressing neuronal apoptosis. Mechanistic studies reveal its neuroprotection is mediated through inhibition of the AGE‐RAGE/MAPK pathway, providing a preclinical foundation for stroke therapeutics development.
Jia Luo   +8 more
wiley   +1 more source

Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain. [PDF]

open access: yesPLoS ONE, 2014
18β-Glycyrrhetinic acid (GA) is the aglycone of glycyrrhizin that is a component of Glycyrrhiza, and has several pharmacological actions in the central nervous system.
Kazushige Mizoguchi   +3 more
doaj   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

open access: yesAdvanced Science, Volume 13, Issue 6, 30 January 2026.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo   +18 more
wiley   +1 more source

A Review of the Mechanisms of Action of the Herbal Medicine, STW 5‐II, Underlying Its Efficacy in Disorders of Gut–Brain Interaction

open access: yesNeurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
The pathophysiology of functional dyspepsia and irritable bowel syndrome includes altered motility, secretion, sensitivity to sensory signals, impaired epithelial barrier function, inflammation, and gut dysbiosis. The phytomedicine, STW 5‐II, represents a multi‐targeted approach, addressing these pathophysiologies.
Anita Annaházi   +6 more
wiley   +1 more source

Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species

open access: yesJournal of Advanced Research, 2015
Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and as sweetener in the food industry.
Mohamed A. Farag   +2 more
doaj   +1 more source

Licorice‐Induced Pseudoaldosteronism Caused by Rikkunshito in an Extremely Low Birth Weight Infant

open access: yesPediatrics International, Volume 68, Issue 1, January/December 2026.
ABSTRACT We report an extremely low birth weight infant with gastroesophageal reflux disease who developed persistent hypokalemia and metabolic alkalosis after treatment with rikkunshito. These findings gradually resolved after discontinuation of rikkunshito and potassium supplementation, suggesting licorice‐induced pseudoaldosteronism.
Toshihiro Nakayama   +4 more
wiley   +1 more source

Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate‐Induced Liver Injury

open access: yesOxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Methotrexate (MTX) is a widely used chemotherapeutic and immunosuppressive agent for treating various malignancies, autoimmune diseases (AIDs), and inflammatory disorders. Despite its therapeutic efficacy, long term or high‐dose MTX treatment is associated with a significant risk of hepatotoxicity, leading to MTX‐induced liver injury (MTX‐LI).
Bushra Zia   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy