Glycyrrhizic Acid and Its Hydrolyzed Metabolite 18β-Glycyrrhetinic Acid as Specific Ligands for Targeting Nanosystems in the Treatment of Liver Cancer [PDF]
Pharmaceutics, 2021 Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti-inflammatory, anti-ulcerative, antiallergic, immunomodulatory, antiviral ...
Luciano A. Stecanella +5 more
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18β-Glycyrrhetinic Acid Protects against Cholestatic Liver Injury in Bile Duct-Ligated Rats [PDF]
Antioxidants, 2022 18β-Glycyrrhetinic acid is a nutraceutical agent with promising hepatoprotective effects. Its protective mechanisms against cholestatic liver injury were further investigated in a rodent model of extrahepatic cholestasis caused by Bile Duct Ligation (BDL)
Pin-Ho Pan +7 more
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18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis [PDF]
Advanced ScienceThe limited efficacy and slow onset of current antidepressants underscore the urgent need for novel therapeutic strategies. Here, we established a novel zebrafish inflammation‐based screening model and identified 18β‐glycyrrhetinic acid (18β‐GA) as a ...
Hua Gan +11 more
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Application of 18β-glycyrrhetinic acid Fluorescent probes in cell imaging [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryFluorescently labelled small molecule probes (fluorescent probes) play an important role in cell imaging and are often used in combination with light-affinity probes to determine the subcellular localisation of target proteins.
Yifan Zhao +9 more
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Genomic and transcriptomics analysis reveal putative secreted proteins expressed of Pasteurella multocida during 18β-glycyrrhetinic acid treatment [PDF]
Frontiers in Veterinary SciencePasteurella multocida is a gram-negative opportunistic pathogen that can infect both domestic animals and humans, leading to large economic losses to the livestock industry. 18β-Glycyrrhetinic acid, the main active component of Glycyrrhiza glabra L., has
Zhongyuan Wu +9 more
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Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity [PDF]
Molecules, 2021 Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water.
Wei-Yan Quan +6 more
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18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice [PDF]
Scientific Reports, 2022 18β-Glycyrrhetinic acid (18β-GA), the main bioactive component of Glycyrrhizae Radix, is considered a promising anti-inflammatory and antioxidant agent.
Jianming Liu +4 more
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Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid [PDF]
Beilstein Journal of Organic Chemistry, 2020 In the present study, a practical method to prepare piperazinyl amides of 18β-glycyrrhetinic acid was developed. Two main procedures for the construction of important intermediate 8 are discussed.
Dong Cai +9 more
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Integrated network toxicology, machine learning algorithms and TMT proteomics reveal the mechanism of 18β glycyrrhetinic acid against gastric cancer [PDF]
Frontiers in GeneticsThe purpose of this paper is to explore the mechanism of 18β glycyrrhetinic acid (18β-GRA) in treating gastric cancer. Firstly, the toxicological effects of 18β-GRA were predicted using the ProTox3.0 database.
Doudou Lu +8 more
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18β-Glycyrrhetinic acid-loaded silver nanoparticles mitigate neuroinflammation and endoplasmic reticulum stress in the brain tissue of diabetic rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Diabetes mellitus (DM) causes oxidative stress, neuroinflammation, and endoplasmic reticulum (ER) dysfunction that contribute to neurodegeneration.
Seçil Nazife Parlak +4 more
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