Results 71 to 80 of about 2,516,936 (145)

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, Volume 13, Issue 6, 30 January 2026.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

A Review of the Mechanisms of Action of the Herbal Medicine, STW 5‐II, Underlying Its Efficacy in Disorders of Gut–Brain Interaction

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
The pathophysiology of functional dyspepsia and irritable bowel syndrome includes altered motility, secretion, sensitivity to sensory signals, impaired epithelial barrier function, inflammation, and gut dysbiosis. The phytomedicine, STW 5‐II, represents a multi‐targeted approach, addressing these pathophysiologies.
Anita Annaházi, Rudolf Bauer, Thomas Efferth, Mohamed T. Khayyal, Michael Schemann, Gudrun Ulrich‐Merzenich, Christine Feinle‐Bisset   +6 more
wiley   +1 more source

Licorice‐Induced Pseudoaldosteronism Caused by Rikkunshito in an Extremely Low Birth Weight Infant

Pediatrics International, Volume 68, Issue 1, January/December 2026.
ABSTRACT We report an extremely low birth weight infant with gastroesophageal reflux disease who developed persistent hypokalemia and metabolic alkalosis after treatment with rikkunshito. These findings gradually resolved after discontinuation of rikkunshito and potassium supplementation, suggesting licorice‐induced pseudoaldosteronism.
Toshihiro Nakayama, Naofumi Hanyu, Shonosuke Nara, Takashi Yamazaki, Gaku Yamanaka   +4 more
wiley   +1 more source

Plasma concentrations of geissoschizine methyl ether, hirsuteine, and 18β-glycyrrhetinic acid after oral administration of yokukansan.

, 2015
A; geissoschizine methyl ether, B; hirsuteine, and C; 18β-glycyrrhetinic acid. Blood samples were collected at 0 (beginning of the study), 0.25, 0.5, 1, 2, 3, 4, 8, 10, 12, 14, 24, and 48 h after administration of yokukansan (YKS, 2.5, 5.0, or 7.5 g/day).
Masaya Munekage (766587), Ian Fukudome (766589), Eri Munekage (766590), Kengo Ichikawa (766588), Kazuhiro Hanazaki (766593), Hiroyuki Kitagawa (766586), Yasushi Igarashi (766592), Takashi Matsumoto (5861), Haruo Hanyu (397117), Yuka Takezaki (766591)   +9 more
core   +1 more source

Exploring New Structural Features of the 18β-Glycyrrhetinic Acid Scaffold for the Inhibition of Anaplastic Lymphoma Kinase

Molecules, 2019
Novel 18β-glycyrrhetinic acid derivatives possessing a carbamate moiety and structurally similar ester derivatives were developed and evaluated for their efficacy as antitumor inhibitors.
Dong Cai, ZhiHua Zhang, Yu Chen, YanYan Zhang, YuQi Sun, YiXia Gong   +5 more
doaj   +1 more source

Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate‐Induced Liver Injury

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Methotrexate (MTX) is a widely used chemotherapeutic and immunosuppressive agent for treating various malignancies, autoimmune diseases (AIDs), and inflammatory disorders. Despite its therapeutic efficacy, long term or high‐dose MTX treatment is associated with a significant risk of hepatotoxicity, leading to MTX‐induced liver injury (MTX‐LI).
Bushra Zia, Mouza Hasan Alqaishi Alshehhi, Azimullah Sheikh, Samir Mirza, Sandeep B. Subramanya, Shreesh K. Ojha, Priya Gusain   +6 more
wiley   +1 more source

The Antitussive Activity of Glycyrrhetinic Acid and its Derivatives

, 1961
The antitussive activity of 18β-glycyrrhetinic acid has been investigated using chemical stimulation in the unanaesthetised guinea-pig and electrical stimulation in the lightly anaesthetised cat.
W G Smith, Doreen M Anderson
core   +1 more source

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR

Molecules, 2014
Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides is reported.
Yong-An Yang, Wen-Jian Tang, Xin Zhang, Ji-Wen Yuan, Xin-Hua Liu, Hai-Liang Zhu   +5 more
doaj   +1 more source

Anti-proliferative and differentiation-inducing effects of glycyrrhizin and 18[beta]-glycyrrhetinic acid on neuroblastoma cells in vitro. [PDF]

, 2003
Lee Kin-wah.Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.Includes bibliographical references (leaves 187-203).Abstracts in English and Chinese.ACKNOWLEDGEMENTS --- p.iABBREVIATIONS --- p.iiABSTRACT --- p.viCHINESE ABSTRACT --- p.ixTABLE OF

core  

Differential induction of isolated lymphoid follicles in the gut by 18β-glycyrrhetinic acid. [PDF]

, 2014
18β-glycyrrhetinic acid (GRA) is a pharmacologically active component of licorice root with documented immunomodulatory properties. We reported that GRA administered orally to mice induces B cell recruitment to isolated lymphoid follicles (ILF) in the ...
Jay M Hendricks, Diana C Lowe, Michele E Hardy   +2 more
core   +1 more source