Results 1 to 10 of about 97,768,533 (136)

2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids [PDF]

Journal of Virology
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment
Ketki Patil, B. Vijayalakshmi Ayyar, Nicole M. Hayes, Frederick H. Neill, Lars Bode, Mary K. Estes, Robert L. Atmar, Sasirekha Ramani   +7 more
doaj   +4 more sources

Assessment of 2′-Fucosyllactose and Lacto-N-Neotetraose Solution as an Irrigant in E. faecalis-Infected Root Canals: An In Vitro Study [PDF]

Clinics and Practice
Background: Given the lack of an ideal endodontic irrigant on the market, this study evaluates the antimicrobial potential of a formulated solution of 2′-fucosyllactose and lacto-N-neotetraose against E. faecalis within infected root canals, and explores
Francesco Puleio, Rosario Pirri, Vincenzo Tosco, Angelo Sergio Lizio, Paola Tripodi, Isabella La Spina, Vincenza La Fauci, Raffaele Squeri   +7 more
doaj   +3 more sources

The Human Milk Oligosaccharide 2′-Fucosyllactose Alleviates Liver Steatosis, ER Stress and Insulin Resistance by Reducing Hepatic Diacylglycerols and Improved Gut Permeability in Obese Ldlr-/-.Leiden Mice

Frontiers in Nutrition, 2022
Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is associated with gut dysbiosis, enhanced gut permeability, adiposity and insulin resistance. Prebiotics such as human milk oligosaccharide 2′-fucosyllactose are thought
Eveline Gart, Kanita Salic, Martine C. Morrison, Martin Giera, Joline Attema, Christa de Ruiter, Martien Caspers, Frank Schuren, Ivana Bobeldijk-Pastorova, Marianne Heer, Yan Qin, Robert Kleemann   +11 more
doaj   +3 more sources

Synthesis of 2′-fucosyllactose using multi-enzyme cascade with cofactor regeneration [PDF]

Scientific Reports
2′-Fucosyllactose (2′-FL) is a major human milk oligosaccharide with nutritional and medicinal benefits, widely used in infant formula and nutraceuticals. Now most studies focus on the synthesis of 2′-FL in vivo starting from glucose and glycerol.
Chenqi Cao, Yi Bai, Mengxin Zhang, Shahin Shah Khan, Yu Ji, Luo Liu   +5 more
doaj   +2 more sources

2′-Fucosyllactose Attenuates Fusobacterium nucleatum Virulence and Modulates the Oral Microbiota [PDF]

Microorganisms
Fusobacterium nucleatum (F. nucleatum) is a key periodontal pathobiont associated with oral inflammation. This bacterium forms biofilms and expresses adhesins that facilitate its adhesion to and invasion of gingival epithelial cells.
Xinyu Wu, Shuangshuang Han, Yifeng Wang, Xintong Chen, Sijia Liu, Mengxiang Li, Shan Lin, Liying Feng, Xiaoya Guo, Zhengang Li, Huilin Hao, Xin Wang, Di Huang, Lu Feng, Bin Liu, Lei Wang   +15 more
doaj   +2 more sources

Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production [PDF]

Microbial Cell Factories
Background 2′-Fucosyllactose (2′-FL) is a predominant human milk oligosaccharide that significantly enhances infant nutrition and immune health. This study addresses the need for a safe and economical production of 2’-FL by employing Generally Recognized
Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh   +6 more
doaj   +2 more sources

Microbiota-targeted strategies in IBD: therapeutic promise of 2′-fucosyllactose and beyond [PDF]

Therapeutic Advances in Gastroenterology
Inflammatory bowel diseases (IBD) are chronic and recurrent conditions of the gastrointestinal tract. IBD is often challenging to manage due to the complex etiology and involvement of multiple dysregulated immune pathways.
Nicholas Fanous, Nicholas J. Talley, Thanaboon Chaemsupaphan, Esther Lee, Binod Rayamajhee, Shaghayegh Baradaran Ghavami, Nesa Kazemifard, Hamid Asadzadeh Aghdaei, Emil Chuang, Rupert W. Leong   +9 more
doaj   +2 more sources

The Effect of 2′-Fucosyllactose on Gut Health in Aged Mice [PDF]

Foods
This study aimed to explore the effect of 2′-Fucosyllactose (2′-FL) on the gut health of aged mice. The results revealed that 2′-FL intervention effectively improved the intestinal permeability and reduced the serum diamine oxidase (DAO) level in aged ...
Songsong Jiang, Yang Li, Tingting Luo, Yutong Huang, Huilian Che, Jinzhu Pang, Xiangren Meng   +6 more
doaj   +2 more sources

2′-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum [PDF]

Current Research in Food Science
2′-Fucosyllactose (2′-FL), one of the most representative oligosaccharides in human milk, is intimately linked to the enrichment of specific Bifidobacterium species.
Jingfang Du, Hong Yang
doaj   +2 more sources

In vitro competition with Bifidobacterium strains impairs potentially pathogenic growth of Clostridium perfringens on 2′-fucosyllactose [PDF]

Gut Microbes
Fortifying infant formula with human milk oligosaccharides, such as 2'-fucosyllactose (2'-FL), is a global trend. Previous studies have shown the inability of pathogenic gut microbes to utilize 2'-FL. However, the present study demonstrates that the type
Aruto Nakajima, Aleksandr A. Arzamasov, Mikiyasu Sakanaka, Ryuta Murakami, Tomoya Kozakai, Keisuke Yoshida, Toshihiko Katoh, Miriam N. Ojima, Junko Hirose, Saeko Nagao, Jin-Zhong Xiao, Toshitaka Odamaki, Dmitry A. Rodionov, Takane Katayama   +13 more
doaj   +2 more sources