Results 11 to 20 of about 97,768,553 (153)

2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids [PDF]

Journal of Virology
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment
Ketki Patil, B. Vijayalakshmi Ayyar, Nicole M. Hayes, Frederick H. Neill, Lars Bode, Mary K. Estes, Robert L. Atmar, Sasirekha Ramani   +7 more
doaj   +3 more sources

Assessment of 2′-Fucosyllactose and Lacto-N-Neotetraose Solution as an Irrigant in E. faecalis-Infected Root Canals: An In Vitro Study [PDF]

Clinics and Practice
Background: Given the lack of an ideal endodontic irrigant on the market, this study evaluates the antimicrobial potential of a formulated solution of 2′-fucosyllactose and lacto-N-neotetraose against E. faecalis within infected root canals, and explores
Francesco Puleio, Rosario Pirri, Vincenzo Tosco, Angelo Sergio Lizio, Paola Tripodi, Isabella La Spina, Vincenza La Fauci, Raffaele Squeri   +7 more
doaj   +3 more sources

A comprehensive safety evaluation of approved 2′-fucosyllactose for human nutritional applications in China [PDF]

Frontiers in Toxicology
Background2′-Fucosyllactose (2′-FL), as a significant human milk oligosaccharide, plays a crucial role in infant formula products. This study aims to provide a scientific basis for the safe application of 2′-FL by systematically evaluating its ...
Jiangge Zheng, Huali Wang, Wenfeng Liu, Zhongzhou Chen, Jiyue Zhang, Jianbo Zhang   +5 more
doaj   +2 more sources

Synthesis of 2′-fucosyllactose using multi-enzyme cascade with cofactor regeneration [PDF]

Scientific Reports
2′-Fucosyllactose (2′-FL) is a major human milk oligosaccharide with nutritional and medicinal benefits, widely used in infant formula and nutraceuticals. Now most studies focus on the synthesis of 2′-FL in vivo starting from glucose and glycerol.
Chenqi Cao, Yi Bai, Mengxin Zhang, Shahin Shah Khan, Yu Ji, Luo Liu   +5 more
doaj   +2 more sources

Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production [PDF]

Microbial Cell Factories
Background 2′-Fucosyllactose (2′-FL) is a predominant human milk oligosaccharide that significantly enhances infant nutrition and immune health. This study addresses the need for a safe and economical production of 2’-FL by employing Generally Recognized
Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh   +6 more
doaj   +2 more sources

Ratio-Dependent Regulation of Butyrate Production by 2′-Fucosyllactose and Fructooligosaccharides in a Bifidobacterium bifidum-Faecalibacterium prausnitzii Co-Culture [PDF]

Microorganisms
An appropriate 2′-fucosyllactose (2′-FL) and fructooligosaccharides (FOS) mixing ratio may enhance butyrate production through substrate complementarity and metabolite-mediated interactions; however, the substrate balance required for this effect remains
Sotaro Iguchi, Haruka Onodera, Yosuke Komatsu, Takeshi Kokubo   +3 more
doaj   +2 more sources

Neonatal 2′-Fucosyllactose Supplementation Modulates Exploratory Behavior and Hippocampal Synaptic Plasticity in Rats Through Gut Microbiota and Metabolic Remodeling [PDF]

Foods
2′-Fucosyllactose (2′-FL) represents a significant constituent within human milk oligosaccharides, and its benefits for intestinal health and neurodevelopment in infants and young children have been widely recognized.
Miao Yu, Jin Wang, Ruixin Kou, Bingye Xu, Weiqian Zhang, Ying Zhang, Jingmin Liu, Shuo Wang   +7 more
doaj   +2 more sources

2′-Fucosyllactose Attenuates Fusobacterium nucleatum Virulence and Modulates the Oral Microbiota [PDF]

Microorganisms
Fusobacterium nucleatum (F. nucleatum) is a key periodontal pathobiont associated with oral inflammation. This bacterium forms biofilms and expresses adhesins that facilitate its adhesion to and invasion of gingival epithelial cells.
Xinyu Wu, Shuangshuang Han, Yifeng Wang, Xintong Chen, Sijia Liu, Mengxiang Li, Shan Lin, Liying Feng, Xiaoya Guo, Zhengang Li, Huilin Hao, Xin Wang, Di Huang, Lu Feng, Bin Liu, Lei Wang   +15 more
doaj   +2 more sources

Human milk oligosaccharide 2′-fucosyllactose guards norovirus histo-blood group antigen co-factor binding site [PDF]

J Virol
Histo-blood group antigens (HBGAs) are critical polymorphic glycan co-factors required for most norovirus infections (1, 2). However, human milk oligosaccharide (HMO) 2’-fucosyllactose (2’-FL), a component of human breast milk and made up of related ...
Irie, Hiro, Kher, Gargi, Haselhorst, Thomas, Tame, Jeremy RH, von Itzstein, Mark, Rudd, Penny A, Hansman, Grant S, Pancera, Marie   +7 more
core   +2 more sources

Microbiota-targeted strategies in IBD: therapeutic promise of 2′-fucosyllactose and beyond [PDF]

Therapeutic Advances in Gastroenterology
Inflammatory bowel diseases (IBD) are chronic and recurrent conditions of the gastrointestinal tract. IBD is often challenging to manage due to the complex etiology and involvement of multiple dysregulated immune pathways.
Nicholas Fanous, Nicholas J. Talley, Thanaboon Chaemsupaphan, Esther Lee, Binod Rayamajhee, Shaghayegh Baradaran Ghavami, Nesa Kazemifard, Hamid Asadzadeh Aghdaei, Emil Chuang, Rupert W. Leong   +9 more
doaj   +2 more sources