Results 21 to 30 of about 97,768,553 (153)

A Multi-Functional Prebiotic Strategy: Crosslinked 2′-Fucosyllactose-Potato Protein Hydrolysate Conjugates Encapsulating Resveratrol for Co-Delivery to Beneficial Gut Bacteria [PDF]

Foods
Prebiotics are predominantly indigestible carbohydrate-based substrates selectively-utilized by beneficial gut-microbes to support host-health. We previously developed protein-containing prebiotics that co-deliver carbohydrate and protein substrates to ...
Stav Peled, Amit Sontag, Ravit Edelman, Yoav D. Livney   +3 more
doaj   +2 more sources

“Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” [PDF]

Gut Microbes
International audienceFood allergies are linked to dysfunction in intestinal microbiota, the immune system and the intestinal epithelial barrier, leading to immune tolerance failure at birth.
Lollier, Virginie, Rousseaux, Anaïs, Barbarot, Sébastien, Le Romancer, Marine, Bodinier, Marie, Brosseau, Carole, de Carvalho, Marion, Ropers, Marie-Hélène   +7 more
core   +2 more sources

Immunomodulatory and Prebiotic Effects of 2′-Fucosyllactose in Suckling Rats [PDF]

Frontiers in Immunology, 2019
Human milk oligosaccharides are unconjugated complex glycans present in high concentration in human milk that serve as pre-biotics and immunomodulators.
Ignasi Azagra-Boronat, Ignasi Azagra-Boronat, Malén Massot-Cladera, Malén Massot-Cladera, Jordi Mayneris-Perxachs, Karen Knipping, Karen Knipping, Belinda van't Land, Belinda van't Land, Sebastian Tims, Bernd Stahl, Johan Garssen, Johan Garssen, Àngels Franch, Àngels Franch, Margarida Castell, Margarida Castell, M. José Rodríguez-Lagunas, M. José Rodríguez-Lagunas, Francisco J. Pérez-Cano, Francisco J. Pérez-Cano   +20 more
doaj   +3 more sources

Supplementation with 2′-fucosyllactose, a prebiotic human milk oligosaccharide (HMO), in a magnesium-containing medical food reduces chemotherapy-induced mucositis in Wistar rats [PDF]

Frontiers in Nutrition
Mucositis is a common debilitating complication of chemotherapy in cancer patients that limits enteral nutrition, causes diarrhea, dehydration and electrolyte wasting.
Sourabh Kharait, Sourabh Kharait, Matthew Wilcox, Kyle Stockdale-Stanforth, Vishnu Thakare   +4 more
doaj   +2 more sources

Bifidogenic Effect of 2′-Fucosyllactose (2′-FL) on the Gut Microbiome of Healthy Formula-Fed Infants: A Randomized Clinical Trial [PDF]

Nutrients
Breast milk is rich in bioactive components, especially human milk oligosaccharides (HMOs), which are crucial for establishing gut microbiota. The 2′-FL (2-Fucosyllactose), one of the most abundant oligosaccharides in breast milk, functions as a ...
Tamara Lazarini, Humberto Araujo Filho, Karina Tonon, Mauro Morais   +3 more
core   +2 more sources

Inulin-type fructans and 2’fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial [PDF]

, 2023
There is increasing interest in the bi-directional relationship existing between the gut and brain and the effects of both oligofructose and 2'fucosyllactose to alter microbial composition and mood state.
Robert A. Rastall, Claire M. Williams, Jackson, Peter P. J., Rastall, Robert A., Jessica van Harsselaar, Stephan Theis, Peter PJ. Jackson, Williams, Claire M., Anisha Wijeyesekera, Wijeyesekera, Anisha, van Harsselaar, Jessica, Theis, Stephan   +11 more
core   +1 more source

2′-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway

Foods, 2022
The imbalance of reactive oxygen species is the main cause in aging, accompanied by oxidative stress. As the most abundant in human milk oligosaccharides (HMOs), 2′-Fucosyllactose (2′-FL) has been confirmed to have great properties in immunity regulation
Jin Wang, Jia-Qiang Hu, Yu-Jie Song, Jia Yin, Yuan-Yi-Fei Wang, Bo Peng, Bo-Wei Zhang, Jing-Min Liu, Lu Dong, Shuo Wang   +9 more
doaj   +1 more source

The Milk Active Ingredient, 2′-Fucosyllactose, Inhibits Inflammation and Promotes MUC2 Secretion in LS174T Goblet Cells In Vitro

Foods, 2023
In several mice inflammatory models, human milk oligosaccharides (HMOs) were shown to protect the intestinal barrier by promoting mucin secretion and suppressing inflammation. However, the functions of the individual HMOs in enhancing mucin expression in
Qianqian Yao, Huiying Li, Yanan Gao, Nan Zheng, Véronique Delcenserie, Jiaqi Wang   +5 more
doaj   +1 more source

Safety of 2′‐fucosyllactose (2’‐FL) produced by a derivative strain (APC199) of Corynebacterium glutamicum ATCC 13032 as a novel food pursuant to Regulation (EU) 2015/2283 [PDF]

, 2022
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 2′‐fucosyllactose (2’‐FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
Schlatter, Josef Rudolf, Tsabouri, S., Neuhäuser-Berthold, M., Castenmiller, Jacqueline, Prieto Maradona, Miguel, Schlatter, J. R., Maciuk, A., Poulsen, Morten, Pelaez, Carmen, Bohn, Torsten, Fernandez, Estefania Noriega, De Henauw, StefaanGE398010007602930000-0003-4141-5432F47B132E-F0ED-11E1-A9DE-61C894A0A6B4, de Henauw, S., Hirsch-Ernst, K. I., Naska, Androniki, Frenzel, T., Hirsch-Ernst, Karen Ildico, McArdle, Harry J., van Loveren, Henk, Thies, F., Noriega Fernández, Estefanía, Tsabouri, Sophia, Turck, Dominique, Siani, Alfonso, EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Naska, A., Noriega Fernández, E., Maradona, Miguel Prieto, Vinceti, Marco, Mangelsdorf, I., Nutr Novel Foods Food A, EFSA Panel, Vinceti, M., Cubadda, Francesco, Frenzel, Thomas, Prieto Maradona, M., Knutsen, Helle Katrine, Neuhäuser-Berthold, Monika, Pentieva, K., Knutsen, H. K., Cubadda, F., Pentieva, Kristina, Poulsen, M., McArdle, Harry J, Heinonen, Marina, van Loveren, H., Mangelsdorf, Inge, Thies, Frank, Pelaez, C., Colombo, Paolo, Mcardle, H. J., Marchelli, R., Neuhäuser‐Berthold, Monika, Maciuk, Alexandre, Bohn, T., Heinonen, M., Colombo, P., De Henauw, Stefaan, Marchelli, Rosangela, Hirsch‐Ernst, Karen Ildico, Siani, A., Castenmiller, J.   +60 more
core   +3 more sources

Anti-Neuroinflammatory Effects of the Human Milk Oligosaccharide, 2′-Fucosyllactose, Exerted via Modulation of M2 Microglial Activation in a Mouse Model of Ischemia–Reperfusion Injury

Antioxidants, 2023
Cerebral ischemic stroke is one of the leading causes of death and disability worldwide. 2′-fucosyllactose (2′-FL), a human milk oligosaccharide, exerts anti-inflammatory effects and plays a protective role in arterial thrombosis; however, its role in ...
Malk Eun Pak, Yeon-Ji Kim, Hanhae Kim, Chul Soo Shin, Jong-Won Yoon, Seon-min Jeon, Young-Ha Song, Kyungho Kim   +7 more
doaj   +1 more source