Results 1 to 10 of about 6,185 (114)

Photorelease of 2-Arachidonoylglycerol in Live Cells. [PDF]

J Am Chem Soc, 2019
2-Arachidonoylglycerol (2-AG) is acting as a full agonist of cannabinoid receptor 1 and 2. Direct manipulation of 2-AG levels is a challenging task. The amphiphilic properties and the instability of 2-AG in aqueous media complicate its use as a drug-like molecule.
Laguerre A, Hauke S, Qiu J, Kelly MJ, Schultz C.   +4 more
europepmc   +4 more sources

Unbiased assessment of 2-arachidonoylglycerol in cardiovascular inflammation. [PDF]

Sci Rep
Abstract 2-arachidonoylglycerol (2-AG) is an endogenous modulator of inflammatory processes. Recent studies demonstrate its key role in inflammatory cardiovascular diseases, such as atherosclerosis and left ventricular remodelling.
Nöthel M, Dorer F, Odainic A, Krause C, Rüthing M, Spitzer J, Strube U, Weise T, Lütjohann D, Nickenig G, Schmidt SV, Jehle J.   +11 more
europepmc   +2 more sources

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. [PDF]

PLoS One, 2018
The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been studied extensively, the significance of 2-AG for atherogenesis is less well characterized.The impact of 2-AG
Jehle J, Schöne B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G.   +11 more
europepmc   +5 more sources

2-Arachidonoylglycerol [PDF]

Cancer Research, 2004
Abstract Endocannabinoids have been implicated in cancer. Increasing endogenous 2-arachidonoylglycerol (2-AG) by blocking its metabolism inhibits invasion of androgen-independent prostate cancer (PC-3 and DU-145) cells. Noladin ether (a stable 2-AG analog) and exogenous CB1 receptor agonists possess similar effects.
Kasem Nithipatikom, Michael P. Endsley, Marilyn A. Isbell, John R. Falck, Yoshiki Iwamoto, Cecilia J. Hillard, William B. Campbell   +6 more
openaire   +1 more source

Conformationally constrained analogues of 2-arachidonoylglycerol [PDF]

Bioorganic & Medicinal Chemistry Letters, 2007
Novel monocyclic analogues of 2-arachidonoylglycerol (2-AG) were designed in order to explore the pharmacophoric conformations of this endocannabinoid ligand at the key cannabinergic proteins. All 2-arachidonoyl esters of 1,2,3-cyclohexanetriol [meso-7 (AM5504), (+/-)-8 (AM5503), and meso-9 (AM5505)] were synthesized by regioselective acylation of 2,3 ...
Subramanian K, Vadivel, Sundararaman, Vardarajan, Richard I, Duclos, JodiAnne T, Wood, Jianxin, Guo, Alexandros, Makriyannis   +5 more
openaire   +2 more sources

2-Arachidonoylglycerol (2-AG) membrane transport: History and outlook [PDF]

The AAPS Journal, 2006
Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enters the cell by a specific 2-AG transporter, via the putative anandamide transporter, or by simple diffusion. In this review, the uptake
Anita, Hermann, Martin, Kaczocha, Dale G, Deutsch   +2 more
openaire   +2 more sources

2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts [PDF]

Cell Cycle, 2014
Platelets modulate vascular system integrity, and their loss is critical in haematological pathologies and after chemotherapy. Therefore, identification of molecules enhancing platelet production would be useful to counteract thrombocytopenia. We have previously shown that 2-arachidonoylglycerol (2-AG) acts as a true agonist of platelets, as well as it
GASPERI, VALERIA, AVIGLIANO, LUCIANA, Evangelista, D, Oddi, S, Chiurchiù, V, Lanuti, M, Maccarrone, M, CATANI, MARIA VALERIA   +7 more
openaire   +3 more sources

2-arachidonoylglycerol signaling impairs short-term fear extinction [PDF]

Translational Psychiatry, 2016
AbstractImpairments in fear extinction are thought to be central to the psychopathology of posttraumatic stress disorder, and endocannabinoid (eCB) signaling has been strongly implicated in extinction learning. Here we utilized the monoacylglycerol lipase inhibitor JZL184 to selectively augment brain 2-AG levels combined with an auditory cue fear ...
Hartley, ND, Gunduz-Cinar, O, Halladay, L, Bukalo, O, Holmes, A, Patel, S   +5 more
openaire   +3 more sources

2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism [PDF]

Cell Metabolism, 2012
The endocannabinoid system plays a critical role in the control of energy homeostasis, but the identity and localization of the endocannabinoid signal involved remain unknown. In the present study, we developed transgenic mice that overexpress in forebrain neurons the presynaptic hydrolase, monoacylglycerol lipase (MGL), which deactivates the ...
Jung, Kwang-Mook, Clapper, Jason R, Fu, Jin, D'Agostino, Giuseppe, Guijarro, Ana, Thongkham, Dean, Avanesian, Agnesa, Astarita, Giuseppe, DiPatrizio, Nicholas V, Frontini, Andrea, Cinti, Saverio, Diano, Sabrina, Piomelli, Daniele   +12 more
openaire   +6 more sources

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults [PDF]

Neuroscience, 2011
While endocannabinoid modulation of both GABAergic and glutamatergic synaptic transmission and plasticity has been extensively investigated, our understanding of the role of endocannabinoids in protecting neurons from harmful insults remains limited. 2-Arachidonoylglycerol (2-AG), the most abundant endogenous ligand and a full agonist for cannabinoid ...
X, Chen, J, Zhang, C, Chen
openaire   +2 more sources