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エンドカンナビノイド研究の新展開　2-arachidonoylglycerolの生理学的機能(Physiological Functions of 2-Arachidonoylglycerol)

エンドカンナビノイド研究の新展開　2-arachidonoylglycerolの生理学的機能(Physiological Functions of 2-Arachidonoylglycerol)
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2-Arachidonoylglycerol and the cannabinoid receptors

Chemistry and Physics of Lipids, 2000
2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated from rat brain and canine gut as an endogenous cannabinoid receptor ligand (Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., Waku, K., 1995.
T, Sugiura, K, Waku
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Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism [PDF]

Journal of Medicinal Chemistry, 2008
A series of 21 analogues of tetrahydrolipstatin (THL, 1) were synthesized and tested as inhibitors of the formation or hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Three of the novel compounds, i.e., 11, 13, and 15, inhibited 2-AG formation via the diacylglycerol lipase alpha (DAGLalpha) with IC 50 values lower than 50 nM (IC 50 of ...
Giorgio Ortar, Tiziana Bisogno, Alessia Ligresti, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo   +5 more
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The Endocannabinoid 2-Arachidonoylglycerol Regulates Platelet Function.

Blood, 2006
Abstract 2-Arachidonoylglycerol (2-AG) is a naturally occurring monoglyceride that activates cannabinoid receptors and meets several key requisites of an endogenous cannabinoid substance. It is present in the brain and hematopoietic cells, including macrophages, lymphocytes and platelets.
Baldassarri S, Bertoni A, Lova P, Reineri S, Sarasso C, Zanfa M, Sanna E, Maccarrone M, Torti M, Sinigaglia F   +9 more
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Monoglyceride Lipase as an Enzyme Hydrolyzing 2‐Arachidonoylglycerol

Chemistry & Biodiversity, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Susanna M, Saario, Jarmo T, Laitinen
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The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair

International Journal of Cardiology, 2021
Endothelial dysfunction promotes atherogenesis, vascular inflammation, and thrombus formation. Reendothelialization after angioplasty is required in order to prevent stent failure. Previous studies have highlighted the role of 2-arachidonoylglycerol (2-AG) in murine experimental atherogenesis and in human coronary artery disease. However, the impact of
Julian, Jehle, Lukas, Eich, Melina, Danisch, Sayeh, Bagheri, Elina, Avraamidou, Philipp, Pfeifer, Vedat, Tiyerili, Laura, Bindila, Beat, Lutz, Georg, Nickenig   +9 more
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Biosynthesis and degradation of the endocannabinoid 2‐arachidonoylglycerol

BioFactors, 2010
Abstract2‐Arachidonoylglycerol (2‐AG) is a monoacylglycerol (MAG) molecule containing an esterified arachidonic acid chain at sn‐2 position of the glycerol backbone. Together with structurally similar N‐arachidonoylethanolamine (anandamide), 2‐AG has been extensively studied as an endogenous ligand of cannabinoid receptors (an endocannabinoid) in brain
Natsuo, Ueda, Kazuhito, Tsuboi, Toru, Uyama, Taira, Ohnishi   +3 more
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Cellular signal transduction by anandamide and 2-arachidonoylglycerol

Chemistry and Physics of Lipids, 2000
Anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol mediate many of their actions via either CB(1) or CB(2) cannabinoid receptor subtypes. These agonist-receptor interactions result in activation of G proteins, particularly those of the G(i/o) family.
A C, Howlett, S, Mukhopadhyay
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Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway

Journal of Cellular Biochemistry, 2011
The endogenous cannabinoid 2-arachidonoylglycerol (2-AG) is described as a platelet agonist able to induce aggregation and to increase intracellular calcium. In the present report we have confirmed these data and demonstrated that the inhibitor of p38MAPK SB203580 and the inhibitor of cPLA(2) metabolism ETYA affect both these parameters. Thus, we aimed
SIGNORELLO, MARIA GRAZIA, Giacobbe, E, LEONCINI, GIULIANA   +2 more
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Endocannabinoids: Anandamide and 2-Arachidonoylglycerol (2-AG)

2021
Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are two key players within the endocannabinoid system. Anandamide and 2-AG are lipid neurotransmitters responsible for actions carried out at various receptors, including the cannabinoid receptors. Although these neurotransmitters act within the same system, they differ in biochemical pathways and ...
Danielle Despina Pete, Samer N. Narouze
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